Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nabendu Pore"'
Autor:
Nabendu Pore, Kate Dixon, Hemant K. Mishra, Jeffrey S. Miller, Bruce Walcheck, Martin Felices
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Natural killer (NK) cells are innate cytotoxic lymphocytes that can recognize assorted determinants on tumor cells and rapidly kill these cells. Due to their anti-tumor effector functions and potential for allogeneic use, various NK cell platforms ar
Publikováno v:
Cancer Immunology Research. 6:B57-B57
Introduction: Antibody-dependent cell cytotoxicity (ADCC) by NK cells is a key mechanism in the anti-cancer effects of therapeutic antibodies. CD16a is an IgG Fc receptor (FcRIII) present on the surface of NK cells and plays essential role in recogni
Autor:
M. Jack Borrok, Ronald Herbst, Ravinder Tammali, Kevin Schifferli, Steven Coats, Matt Flynn, Elaine M. Hurt, Nabendu Pore, David A. Tice, Noel R. Monks
Publikováno v:
Cancer Research. 78:LB-298
MEDI7247 is a first in class ADC consisting of a human anti-ASCT2 monoclonal antibody, site specifically conjugated to highly cytotoxic DNA cross-linking pyrrolobenzodiazepine (PBD) dimers (DAR of 2) via a protease-cleavable linker. ASCT2 (SLC1A5) is
Publikováno v:
Cancer Research. 70:4399-4399
The EphA2 receptor is over-expressed on the surface of many different human tumors, and has been shown to internalize upon ligand or antibody binding. The fully human monoclonal antibody anti-EphA2 antibody was developed by phage display methods and