Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Bernard A. Fox"'
Autor:
Erica Browning, Erika J. Crosby, Takuya Osada, Bernard A. Fox, Carlo Bifulco, Jendy Sell, Irene Wapnir, Melinda L. Telli, Kaitlin Zablotsky, Reneta Hermiz, Kellie Malloy Foerter, Robert H. Pierce, Chaitanya R. Acharya, Kim Jaffe, Donna Bannavong, Mai Hope Le, H. Kim Lyerly, Shawn M. Jensen, Carmen Ballesteros-Merino, David A. Canton, Christopher G. Twitty, Hiroshi Nagata, Lauren Svenson
Publikováno v:
Clin Cancer Res
Purpose: Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand 1 (PD-L1) have entered the therapeutic landscape in TNBC, but only a mino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c48e8953fa4ba2b471eaae121c3944b
https://europepmc.org/articles/PMC8102331/
https://europepmc.org/articles/PMC8102331/
Autor:
Kimberly Samson, Eric Tran, David Ross, Bernard A. Fox, Thomas Duhen, Pippa Newell, Brady Bernard, Carmen Ballesteros-Merino, Venkatesh Rajamanickam
Publikováno v:
Cancer immunology research. 9(6)
Microsatellite-stable (MSS) colorectal cancers are characterized by low mutation burden and limited immune-cell infiltration and thereby respond poorly to immunotherapy. Here, we report a case of metastatic MSS colorectal cancer with a robust antican
Autor:
Sachin Puri, Walter J. Urba, Bernard A. Fox, Rieneke van de Ven, Daniel Haley, Hong-Ming Hu, Christopher Paustian, Traci L Hilton, Brendan D. Curti, Sandra Aung, Christopher Dubay
Publikováno v:
OncoImmunology, 7(12):e1466766. Landes Bioscience
van de Ven, R, Hilton, T L, Hu, H-M, Dubay, C J, Haley, D, Paustian, C, Puri, S, Urba, W J, Curti, B D, Aung, S & Fox, B A 2018, ' Autophagosome-based strategy to monitor apparent tumor-specific CD8 T cells in patients with prostate cancer ', OncoImmunology, vol. 7, no. 12, e1466766 . https://doi.org/10.1080/2162402X.2018.1466766
OncoImmunology, Vol 7, Iss 12 (2018)
Oncoimmunology
van de Ven, R, Hilton, T L, Hu, H-M, Dubay, C J, Haley, D, Paustian, C, Puri, S, Urba, W J, Curti, B D, Aung, S & Fox, B A 2018, ' Autophagosome-based strategy to monitor apparent tumor-specific CD8 T cells in patients with prostate cancer ', OncoImmunology, vol. 7, no. 12, e1466766 . https://doi.org/10.1080/2162402X.2018.1466766
OncoImmunology, Vol 7, Iss 12 (2018)
Oncoimmunology
The immune system plays an essential role in eradicating cancer in concert with various treatment modalities. In the absence of autologous tumor material, no standardized method exists to assess T cell responses against the many antigens that may ser
Autor:
Christian Kugler, Daniel Drömann, Sebastian Marwitz, Shawn M. Jensen, Carmen Ballesteros-Merino, Martin Reck, Torsten Goldmann, Bernard A. Fox, Sven Perner
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
BackgroundThe interplay of immune and cancer cells takes place in the tumor microenvironment where multiple signals are exchanged. The transforming growth factor beta (TGFB) pathway is known to be dysregulated in lung cancer and can impede an effecti
Autor:
Cristina Bergamaschi, Jenifer Bear, George N. Pavlakis, Maggie Cam, Bernard A. Fox, Bethany Nagy, Barbara K. Felber, Antonio Valentin, Hrishikesh Pandit, Dimitris Stellas, Shawn M. Jensen
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundInterleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8+T and natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine, comprising the IL-15 and IL-15 receptor alpha chains (hetIL-15). Se
Autor:
Shu Ching Chang, Cheri P. Goodall, Tiffany C. Blair, Bernard A. Fox, Ryan Montler, Andrew D. Weinberg, Thomas Duhen, Rebekka Duhen, Noel F C C de Miranda, Gary L. Grunkemeier, Jake Moses, Rom Leidner, R.B. Bell, Jason E. McDermott, Tarsem Moudgil
Publikováno v:
Nature Communications
Nature Communications, 9
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, 9
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103+CD39+ tumor-infiltrating CD8 T cells (CD8 TIL) are enriched for tumor-reactive cells b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2a0fecd4c9edf0c4916287156d6bcf
https://hdl.handle.net/1887/79915
https://hdl.handle.net/1887/79915
Autor:
Carmen Ballesteros-Merino, Bernard A. Fox, Phillip A. Wilmarth, Christopher Dubay, Larry L. David, Tyler W. Hulett, Michael E. Afentoulis, Ashok P. Reddy, Shawn M. Jensen
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Background One of today’s greatest hurdles for cancer immunotherapy is the absence of information regarding which tumor antigens are already recognized by patients receiving immunotherapies, and whether those therapies then boost or generate an imm
Autor:
Xintao Hu, Sinnie Sin Man Ng, George N. Pavlakis, Cristina Bergamaschi, Bernard A. Fox, Shawn M. Jensen, Barbara K. Felber, Candido Alicea, Bethany Nagy
Purpose: Adoptive cell transfer (ACT) is a promising immunotherapeutic approach for cancer. Host lymphodepletion is associated with favorable ACT therapy outcomes, but it may cause detrimental effects in humans. We tested the hypothesis that IL15 adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381ed8f253d4be91da5eb7ce0fba17ff
https://europepmc.org/articles/PMC5805388/
https://europepmc.org/articles/PMC5805388/
Autor:
Bernard A. Fox, Rachel E. Sanborn, Brenda Fisher, Rui Li, Herschel Wallen, Kelly Shea Perlewitz, Regan M. Duffy, Yoshinobu Koguchi, William L. Redmond
Publikováno v:
Journal of Clinical Oncology. 37:e20652-e20652
e20652 Background: P has demonstrated improved survival alone or with chemotherapy in untreated adv NSCLC. G may increase antigen cross-presentation and prime CD8 T cell response via tumor apoptosis. This study evaluated P + G in pts with previously-
Autor:
Walter J. Urba, Rachel E. Sanborn, Lana Chisholm, Nicholas P. Morris, Bernard A. Fox, Tarsem Moudgil, Kevin Floyd, Andrew D. Weinberg, Iliana Gonzalez, Joshua M. Walker, Brenda Fisher, Daniel Haley, Eric D. Bernstein, Edwin B. Walker, Nicole Rymarchyk, Tracy L Kelly, Tanisha Meeuwsen, Laurie Delanty-Miller, Todd S. Crocenzi, Magdalena Kovacsovics-Bankowski, Brendan D. Curti, Todd Coffey, William Miller
Publikováno v:
Cancer Research. 73:7189-7198
OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic ce