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pro vyhledávání: '"Ramin Sakhtemani"'
Autor:
Ramin Sakhtemani, Madusha L W Perera, Daniel Hübschmann, Reiner Siebert, Michael S Lawrence, Ashok S Bhagwat
Publikováno v:
Nucleic Acids Research. 50:5145-5157
Activation-induced deaminase (AID) is a DNA-cytosine deaminase that mediates maturation of antibodies through somatic hypermutation and class-switch recombination. While it causes mutations in immunoglobulin heavy and light chain genes and strand bre
Autor:
Ashok S. Bhagwat, Ramin Sakhtemani, Vimukthi Senevirathne, Roger Pique-Regi, Jessica A. Stewart, Madusha L. W. Perera, Michael S. Lawrence
Publikováno v:
J Biol Chem
Activation-induced deaminase (AID) and apolipoprotein B mRNA-editing enzyme catalytic subunit (APOBEC) enzymes convert cytosines to uracils, creating signature mutations that have been used to predict sites targeted by these enzymes. Mutation-based t