Zobrazeno 1 - 10
of 7 819
pro vyhledávání: '"RC254-282"'
Autor:
Takeshi Wakasa, Kentaro Nonaka, Akihito Harada, Yasuyuki Ohkawa, Chie Kikutake, Mikita Suyama, Takashi Kobunai, Kenta Tsunekuni, Kazuaki Matsuoka, Yuki Kataoka, Hiroaki Ochiiwa, Kazutaka Miyadera, Takeshi Sagara, Eiji Oki, Shigehiro Ohdo, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract The fluorinated thymidine analog trifluridine (FTD) is a chemotherapeutic drug commonly used to treat cancer; however, the mechanism by which FTD induces cytotoxicity is not fully understood. In addition, the effect of gain-of-function (GOF)
Externí odkaz:
https://doaj.org/article/d0e4286119c6423db3d09770e905d4cc
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Nuclear receptor coactivator 4 (NCOA4) has recently been recognized as a selective cargo receptor of ferritinophagy participating in ferroptosis. However, NCOA4 is also a coactivator that modulates the transcriptional activity of many vital
Externí odkaz:
https://doaj.org/article/1718fce6eab541aea8f07329fc9b737b
Autor:
Charlotte E. Berry, Carter B. Kendig, Nicholas An, Alexander Z. Fazilat, Andrew A. Churukian, Michelle Griffin, Phoebe M. Pan, Michael T. Longaker, Scott J. Dixon, Derrick C. Wan
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage and the generation of reactive oxygen species, which harm nu
Externí odkaz:
https://doaj.org/article/e4dc38fbc0c942248ccfc4189a4d15e7
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Sepsis, a life-threatening condition caused by infection, is characterized by the dysregulation of immune responses and activation of monocytes. Plac8, a protein, has been implicated in various inflammatory conditions. This study aimed to in
Externí odkaz:
https://doaj.org/article/06817ec10561437fae2cfb2a5481e2b0
Autor:
Dongyun Wang, Yue Li, Guiying Li, Mengyu Liu, Zihui Zhou, Ming Wu, Shan Song, Yawei Bian, Jiajia Dong, Xinran Li, Yunxia Du, Tao Zhang, Yonghong Shi
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive. Protein kinase C-delta (PKC-δ) plays critical roles in the control of growth, differentiatio
Externí odkaz:
https://doaj.org/article/d65bab5722d24471a6688290cf20f3ae
Autor:
Tayyab Shahzad, Ying Dong, Nina K. Behnke, Julia Brandner, Anne Hilgendorff, Cho-Ming Chao, Judith Behnke, Saverio Bellusci, Harald Ehrhardt
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Oxygen toxicity constitutes a key contributor to bronchopulmonary dysplasia (BPD). Critical step in the pathogenesis of BPD is the inflammatory response in the immature lung with the release of pro-inflammatory cytokines and the influx of in
Externí odkaz:
https://doaj.org/article/aa2c60a569e14c6fbe2af26dbe0efc5b
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/287226132d5f49429a04e42a9297df64
Autor:
Lanqi Cen, Zhe Zhang, Yi Sun, Nandie Wu, Jie Shao, Zhaoye Qian, Manman Tian, Yaohua Ke, Baorui Liu
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background The clinical application of peptide vaccines in tumor immunotherapy holds significant promise. Peptide-based tumor vaccines are currently subject to certain limitations in clinical trials, including the challenge of inducing a sus
Externí odkaz:
https://doaj.org/article/d2986432684d451ebc6de3bd09004145
Autor:
Shahram Taeb, Davoud Rostamzadeh, Seyed Mohammad Amini, Mohammad Rahmati, Mohammad Eftekhari, Arash Safari, Masoud Najafi
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract MicroRNAs (miRNAs) are small RNA molecules that regulate genes and are involved in various biological processes, including cancer development. Researchers have been exploring the potential of miRNAs as therapeutic agents in cancer treatment.
Externí odkaz:
https://doaj.org/article/5fc1a86574854ab7b92e291845f7d0a6
Autor:
Shipeng Dai, Fan Xu, Xiaozhang Xu, Tian Huang, Yiming Wang, Hongyu Wang, Yucheng Xie, Lei Yue, Wenhu Zhao, Yongxiang Xia, Jian Gu, Xiaofeng Qian
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Colorectal cancer is among the most common malignant tumors affecting the gastrointestinal tract. Liver metastases, a complication present in approximately 50% of colorectal cancer patients, are a considerable concern. Recently, s
Externí odkaz:
https://doaj.org/article/29fd6be4c78b4f2e9a5e8f329c363c25