Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Mandy L. Ford, Nathan J. Klingensmith, Katherine T. Fay, John D. Lyons, Deena B. Chihade, Zhe Liang, Eileen M. Burd, Shunsuke Otani, Ching-Wen Chen, Craig M. Coopersmith
Publikováno v:
Shock (Augusta, Ga.). 51(4)
Mortality is higher in septic patients with a history of alcohol use disorder than in septic patients without a history of chronic alcohol usage. We have previously described a model of chronic alcohol ingestion followed by sepsis from cecal ligation
Publikováno v:
JCI insight. 3(1)
Memory T cells pose a significant problem to successful therapeutic control of unwanted immune responses during autoimmunity and transplantation, as they are differentially controlled by cosignaling receptors such as CD28 and CTLA-4. Treatment with a
Autor:
Mandy L. Ford, John D. Lyons, Wenxiao Zhang, Annette Hadley, Kimberly M. Ramonell, Kevin W. McConnell, Nathan J. Klingensmith, Craig M. Coopersmith, Ching-Wen Chen, Katherine T. Fay
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188882 (2017)
PLoS ONE
PLoS ONE
Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory processes that results in a state of immune incompetence and can lead to multi-organ failure. CXCR4
Autor:
Craig M. Coopersmith, Lindsay M. Margoles, Kimberly M. Ramonell, John D. Lyons, Kevin W. McConnell, Mara A. Serbanescu, Zhe Liang, Annette Hadley, Mandy L. Ford, Rohit Mittal
CD8 T cell loss and dysfunction have been implicated in the increased susceptibility to opportunistic infections during the later immunosuppressive phase of sepsis, but CD8 T cell activation and attrition in early sepsis remain incompletely understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d909a9513addb7eb2a92398dec996e5f
https://europepmc.org/articles/PMC5069090/
https://europepmc.org/articles/PMC5069090/
Autor:
Aneesh K. Mehta, Christian P. Larsen, Linda Stempora, Allan D. Kirk, Timothy A Weaver, Mandy L. Ford, Denise J. Lo
Publikováno v:
American Journal of Transplantation. 11:22-33
Costimulation blockade (CoB), specifically CD28/B7 inhibition with belatacept, is an emerging clinical replacement for calcineurin inhibitor-based immunosuppression in allotransplantation. However, there is accumulating evidence that belatacept incom
Autor:
Jennifer M. Robertson, Craig M. Coopersmith, Mandy L. Ford, Ching-Wen Chen, Jianfeng Xie, Wenxiao Zhang
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191065 (2018)
PLoS ONE
PLoS ONE
The presence of pre-existing malignancy in murine hosts results in increased immune dysregulation and risk of mortality following a septic insult. Based on the known systemic immunologic changes that occur in cancer hosts, we hypothesized that the pr
Autor:
Ching-Wen Chen, Eileen M. Burd, Craig M. Coopersmith, Zhe Liang, Mandy L. Ford, Alton B. Farris, Lindsay M. Margoles, Rohit Mittal, Katherine T. Fay, John D. Lyons
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 3, p e0149069 (2016)
PLoS ONE, Vol 11, Iss 3, p e0149069 (2016)
Background Mortality is significantly higher in septic patients with cancer than in septic patients without a history of cancer. We have previously described a model of pancreatic cancer followed by sepsis from Pseudomonas aeruginosa pneumonia in whi
Publikováno v:
The Journal of Immunology. 171:6527-6533
Experimental autoimmune encephalomyelitis (EAE) is a mouse model of multiple sclerosis characterized by infiltration of activated CD4+ T lymphocytes into tissues of the CNS. This study investigated the role of CD43 in the induction and progression of
Autor:
Zhe Liang, Mandy L. Ford, Nathan J. Klingensmith, Rohit Mittal, Lindsay M. Margoles, John D. Lyons, Maylene E. Wagener, Craig M. Coopersmith, Mara A. Serbanescu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 11, p e0165886 (2016)
PLoS ONE, Vol 11, Iss 11, p e0165886 (2016)
Sepsis is the leading cause of death in intensive care units in the US, and it is known that chronic alcohol use is associated with higher incidence of sepsis, longer ICU stays, and higher mortality from sepsis. Both sepsis and chronic alcohol use ar
Autor:
Aaron P. Yamniuk, Anish Suri, S. Nadler, Danya Liu, Mandy L. Ford, Christian P. Larsen, James K. Tamura, Maylene E. Wagener, David F. Pinelli, Steven Grant
The use of monoclonal antibodies targeting the CD154 molecule remains one of the most effective means of promoting graft tolerance in animal models, but thromboembolic complications during early clinical trials have precluded their use in humans. Fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00903cf65804b5696851c3e302679433
https://europepmc.org/articles/PMC4287239/
https://europepmc.org/articles/PMC4287239/