Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Mahmoud M. El-Mas"'
Publikováno v:
Prostaglandins & Other Lipid Mediators. 141:1-10
We recently reported that celecoxib, a selective cyclooxygenase-2 (COX2) inhibitor, counteracts the adverse circulatory and renal actions of cyclosporine (CSA). Despite the seemingly advantageous nature of this interaction particularly in clinical se
Autor:
Amal G. Omar, Neamah Mahjoub, Safaa H. Hammoud, Assaad A. Eid, Sahar Alkhansa, Mahmoud M. El-Mas
Publikováno v:
American Journal of Physiology-Renal Physiology. 315:F572-F582
Nephrotoxicity is a serious side effect for the immunosuppressant drug cyclosporine A(CSA). In this study, we tested the hypothesis that administration of calcium channel blockers such as verapamil or nifedipine ameliorates renal CSA-induced renal dy
Publikováno v:
Biomedicine & Pharmacotherapy. 102:309-316
The combined use of cyclosporine (CSA) and nonsteroidal antiinflammatory drugs (NSAIDs) causes exaggerated rises in systolic blood pressure (SBP) and nephrotoxicity. We examined whether these influences relate to the arachidonate/5-lipoxygenase (LOX)
Publikováno v:
Biomedicine & Pharmacotherapy. 101:889-897
We recently reported that exposure to cyclosporine (CSA) plus diclofenac causes hypertension and impairs left ventricular (LV) and cardiac autonomic functions in female rats. Here, we tested the hypothesis that these effects could be mitigated by fac
Publikováno v:
Pharmacological Research. 129:251-261
Cyclosporine, the prototype calcineurin inhibitor, transformed immunosuppressant regimens and practices post-organ transplantation. Therapeutic uses of cyclosporine branched out to include management of different autoimmune disorders. However, multip
Publikováno v:
Toxicology and Applied Pharmacology. 334:110-119
The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we investigated whether (i) under conditions of vascular endothelium dysfunction, the
Publikováno v:
Toxicology Letters. 281:35-43
Ciclosporin A (CSA) has been identified with harmful cardiotoxicity but little, if any, is known about the influence of perinatal exposure upon the cardiac function of the progeny. The present work examines the premise that perinatal contact with CSA
Autor:
Nevine M. El-Deeb, Hanan M. El-Gowelli, Karim S. Ibrahim, Ahmed F. El-Yazbi, Mahmoud M. El-Mas
Publikováno v:
European Journal of Pharmacology. 806:96-104
Cyclosporine (CSA) and nonsteroidal antiinflammatory drugs (NSAIDs) are used together to manage arthritic disorders with an immune component. Previous reports showed contrasting effects for NSAIDs on CSA nephrotoxicity and acute elevations in blood p
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 120:571-581
Non-steroidal anti-inflammatory drugs (NSAIDs) and the immunosuppressant drug cyclosporine (CSA) are concurrently administered in arthritis. Here, we investigated whether diclofenac (non-selective inhibitor of cyclooxygenase-1 and 2, COX-1/COX-2), ce
Publikováno v:
Fundamentalclinical pharmacology. 32(5)
We have previously shown that cyclosporine (CSA) counteracts cardiovascular manifestations induced by endotoxemia (lipopolysaccharide, LPS) such as hypotension and cardiac autonomic dysfunction in conscious rats. In this study, we investigated whethe