Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tomi P. Mäkelä"'
Autor:
Sophie Bamps, Arno Pihlak, Thomas Westerling, Lionel Tafforeau, Damien Hermand, Tomi P. Mäkelä, Jean Vandenhaute
Publikováno v:
Biochemical and biophysical research communications, 325 (4
The Mcs6 CDK together with its cognate cyclin Mcs2 represents the CDK-activating kinase (CAK) of fission yeast Cdc2. We have attempted to determine complexes in which Mcs6 and Mcs2 mediate this and possible other functions. Here we characterize a nov
Autor:
Taija Makinen, Robert E. Ferrell, Kari Alitalo, Ismo Virtanen, Janna Saarela, David N. Finegold, Dontscho Kerjaschki, Tomi P. Mäkelä, Seppo Ylä-Herttuala, Tatiana V. Petrova
Publikováno v:
University of Helsinki
Lymphatic vessels are essential for fluid homeostasis, immune surveillance and fat adsorption, and also serve as a major route for tumor metastasis in many types of cancer. We found that isolated human primary lymphatic and blood vascular endothelial
Autor:
Tomi P. Mäkelä, Nina Korsisaari
Publikováno v:
Journal of Biological Chemistry. 275:34837-34840
Cyclin-dependent kinase 7 (Cdk7) forms a trimeric complex with cyclin H and Mat1 to form the mammalian Cdk-activating kinase, CAK, as well as a part of the basal transcription factor TFIIH, where Cdk7 phosphorylates the C-terminal domain (CTD) of the
Autor:
Arno Pihlak, Véronique Damagnez, Tomi P. Mäkelä, Damien Hermand, Guillaume Cottarel, Thomas Westerling, Jean Vandenhaute
Publikováno v:
The EMBO Journal. 17:7230-7238
Cell cycle progression is dependent on the sequential activity of cyclin-dependent kinases (CDKs). For full activity, CDKs require an activating phosphorylation of a conserved residue (corresponding to Thr160 in human CDK2) carried out by the CDK-act
Publikováno v:
Molecular Biology of the Cell. 7:1335-1342
Transforming growth factor beta (TGF beta) inhibits cell proliferation by inducing a G1 cell-cycle arrest. Cyclin/CDK complexes have been implicated in this arrest, because TGF beta treatment leads to inhibition of cyclin/CDK activity. We have invest
Publikováno v:
Molecular and Cellular Biology. 16:2402-2407
Fibroblasts prepared from retinoblastoma (Rb) gene-negative mouse embryos exhibit a shorter G1 phase of the growth cycle and smaller size than wild-type cells. In addition, the mutant cells are no longer inhibited by low levels of cycloheximide at an
Publikováno v:
Nature. 377:557-560
AN array of tandem heptapeptide repeats at the carboxv -terminal domain (CTD) of the largest subunit of RNA polymerase II constitute a highly conserved structure essential for viability1a¤-3. Studies have established that the CTD is phosphorylated a
Publikováno v:
Molecular biology of the cell. 12(12)
In normal cells, activation of cyclin-dependent kinases (cdks) requires binding to a cyclin and phosphorylation by the cdk-activating kinase (CAK). The Kaposi's sarcoma-associated herpesvirus encodes a protein with similarity to D-type cyclins. This
Autor:
Päivi M. Ojala, Tomi P. Mäkelä, Kazuhito Yamamoto, Stanley J. Korsmeyer, Peter Biberfeld, Esmeralda Castaños-Velez
Publikováno v:
Nature cell biology. 2(11)
v-cyclin encoded by Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV or HHV8) associates with cellular cyclin-dependent kinase 6 (CDK6) to form a kinase complex that promotes cell-cycle progression, but can also induce apoptosis in cells with h
Autor:
René H. Medema, Tea Vallenius, Veronique A. J. Smits, Gert Rijksen, Rob Klompmaker, Tomi P. Mäkelä
Publikováno v:
Journal of biological chemistry, 275(39), 30638. American society for biochemistry and molecular biology
The cyclin-dependent kinase inhibitor p21 is required for a sustained G(2) arrest after activation of the DNA damage checkpoint. Here we have addressed the mechanism by which p21 can contribute to this arrest in G(2). We show that p21 blocks the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad10fb5f40be457c6ee4dd2b8031d50c
https://dspace.library.uu.nl/handle/1874/7907
https://dspace.library.uu.nl/handle/1874/7907