Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tomi P. Mäkelä"'
Publikováno v:
Molecular Biology of the Cell. 7:1335-1342
Transforming growth factor beta (TGF beta) inhibits cell proliferation by inducing a G1 cell-cycle arrest. Cyclin/CDK complexes have been implicated in this arrest, because TGF beta treatment leads to inhibition of cyclin/CDK activity. We have invest
Autor:
René H. Medema, Tea Vallenius, Veronique A. J. Smits, Gert Rijksen, Rob Klompmaker, Tomi P. Mäkelä
Publikováno v:
Journal of biological chemistry, 275(39), 30638. American society for biochemistry and molecular biology
The cyclin-dependent kinase inhibitor p21 is required for a sustained G(2) arrest after activation of the DNA damage checkpoint. Here we have addressed the mechanism by which p21 can contribute to this arrest in G(2). We show that p21 blocks the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad10fb5f40be457c6ee4dd2b8031d50c
https://dspace.library.uu.nl/handle/1874/7907
https://dspace.library.uu.nl/handle/1874/7907
Publikováno v:
University of Helsinki
Germline mutations of the LKB1 tumor suppressor gene lead to Peutz-Jeghers syndrome (PJS), with a predisposition to cancer. LKB1 encodes for a nuclear and cytoplasmic serine/threonine kinase, which is inactivated by mutations observed in PJS patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12245fce537199d93e207c67eb7d8467
https://researchportal.helsinki.fi/en/publications/5eea8c7a-c57b-43fa-89d2-44825824d709
https://researchportal.helsinki.fi/en/publications/5eea8c7a-c57b-43fa-89d2-44825824d709