Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Achim Schmidtko"'
Autor:
Stefanie Peters, Michael Paolillo, Evanthia Mergia, Doris Koesling, Lea Kennel, Achim Schmidtko, Michael Russwurm, Robert Feil
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2313 (2018)
Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms—NO-GC1 and NO-GC2—are known, represents a promising drug target to increase cGMP in the brain. Drug-like sm
Externí odkaz:
https://doaj.org/article/8760d61e1dae47d8953a4136e7e730ac
Publikováno v:
British Journal of Pharmacology. 179:2361-2377
Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and pathophysiological processes. In recent years, more and more studies have uncovered multiple roles of cGMP signalling pathways in the somatosensory system. Accumulating
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology
Cyclic guanosine monophosphate (cGMP) is a unique second messenger molecule formed in different cell types and tissues. cGMP targets a variety of downstream effector molecules and, thus, elicits a very broad variety of cellular effects. Its productio
Autor:
Evanthia Mergia, Michael Paolillo, Robert Feil, Achim Schmidtko, Michael Russwurm, Lea Kennel, Doris Koesling, Stefanie Peters
Publikováno v:
International Journal of Molecular Sciences
Volume 19
Issue 8
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2313 (2018)
Volume 19
Issue 8
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2313 (2018)
Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms&mdash
NO-GC1 and NO-GC2&mdash
are known, represents a promising drug target to increase cGMP in the b
NO-GC1 and NO-GC2&mdash
are known, represents a promising drug target to increase cGMP in the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237a8c5095c42991d47589e01b360ae3
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48487
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48487
Autor:
Jana E. Lorenz, Gerd Geisslinger, Ruirui Lu, Dominique Thomas, Catherine Isabell Real, Domenico Del Turco, Nancy Lippold, Jessica Schlaudraff, Wiebke Kallenborn-Gerhardt, Aaron Bothe, Nerea Ferreirós, Achim Schmidtko
Publikováno v:
Anesthesiology. 121:372-382
Background: Phosphodiesterase 2A (PDE2A) is an evolutionarily conserved enzyme that catalyzes the degradation of the cyclic nucleotides, cyclic adenosine monophosphate, and/or cyclic guanosine monophosphate. Recent studies reported the expression of
Autor:
Wiebke Kallenborn-Gerhardt, Hee-Young Lim, Sandra Heine, Ruirui Lu, Jessica Weiland, Domenico Del Turco, Irmgard Tegeder, Achim Schmidtko, Martin Biel, Stylianos Michalakis, Gerd Geisslinger, Thomas Deller
Publikováno v:
The Journal of Neuroscience. 31:11184-11192
A large body of evidence indicates that nitric oxide (NO) and cGMP contribute to central sensitization of pain pathways during inflammatory pain. Here, we investigated the distribution of cyclic nucleotide-gated (CNG) channels in the spinal cord, and
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 391:347-347
The article "Meeting report of the 8 th International Conference on "cGMP BcGMP: generators, effectors, and therapeutic implications" at Bamberg, Germany, from June 23 to 25, 2017" was originally published Online First without open access. After publ
Publikováno v:
Trends in Neurosciences. 32:339-346
A large body of evidence indicates that nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) essentially contribute to the processing of nociceptive signals in the spinal cord. Many animal studies have unanimously shown that inhibition of NO o
Autor:
Ellen Niederberger, Inga Rauhmeier, Franz Hofmann, Ulrike Sausbier, Wei Gao, Irmgard Tegeder, Achim Schmidtko, Matthias Sausbier, Hans-Dieter Allescher, Winfried Neuhuber, Gerd Geisslinger, Peter Ruth, Andrea Huber, Klaus Scholich
Publikováno v:
The Journal of Neuroscience. 28:1320-1330
The cGMP/cGMP-dependent protein kinase I (cGKI) signaling pathway plays an important role in spinal nociceptive processing. However, downstream targets of cGKI in this context have not been identified to date. Using a yeast two-hybrid screen, we isol
Autor:
Achim, Schmidtko
Publikováno v:
Handbook of experimental pharmacology. 227
A large body of evidence indicates that nitric oxide (NO) plays an important role in the processing of persistent inflammatory and neuropathic pain in the spinal cord. Several animal studies revealed that inhibition or knockout of NO synthesis amelio