Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Barton Wicksteed"'
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 311:R79-R88
Adipose tissue PKA has roles in adipogenesis, lipolysis, and mitochondrial function. PKA transduces the cAMP signal downstream of G protein-coupled receptors, which are being explored for therapeutic manipulation to reduce obesity and improve metabol
Publikováno v:
Islets. 8:125-134
Type 2 diabetes is associated with obesity, insulin resistance and β-cell failure. Therapeutic aims are to reduce adiposity, improve insulin sensitivity and enhance β-cell function. However, it has been proposed that chronically increasing insulin
Publikováno v:
Markussen, L K, Winther, S, Wicksteed, B & Hansen, J B 2018, ' GSK3 is a negative regulator of the thermogenic program in brown adipocytes ', Scientific Reports, vol. 8, 3469, pp. 1-12 . https://doi.org/10.1038/s41598-018-21795-y
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Brown adipose tissue is a promising therapeutic target in metabolic disorders due to its ability to dissipate energy and improve systemic insulin sensitivity and glucose homeostasis. β-Adrenergic stimulation of brown adipocytes leads to an increase
Autor:
Lorna M. Dickson, Barton Wicksteed, Kelly Kaihara, Johanne H. Ellenbroek, Brian T. Layden, Caitlin M.D. Orr
Publikováno v:
Diabetes
Diabetes arises from insufficient insulin secretion and failure of the β-cell mass to persist and expand. These deficits can be treated with ligands to Gs-coupled G-protein-coupled receptors that raise β-cell cAMP. Here we studied the therapeutic p
Autor:
Michael W. Roe, Lorna M. Dickson, Natalia A. Tamarina, David A. Jacobson, Louis H. Philipson, Barton Wicksteed, Kelly Kaihara
Publikováno v:
Diabetes
Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP, restore acute-phas