Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Gerhard Schenk"'
Autor:
Rosely A. Peralta, Hernán Terenzi, Tiago Bortolotto, Ademir Neves, Adailton J. Bortoluzzi, Marcos Paulo da Silva, Cristine Saibert, Gerhard Schenk
Publikováno v:
Journal of inorganic biochemistry. 213
The research reported herein focuses on the synthesis of two new Cu(II) complexes {[Cu2(2-X-4,6-bis(di-2-picolylamino)-1,3,5-triazine], with X = butane-1,4-diamine (2) or N-methylpyrenylbutane-1,4-diamine (3)}, the latter with a pyrene group as a pos
Autor:
Thomas Brück, Manfredi Miraula, Stefan Krco, James A. Larrabee, Liam A. Wilson, Luke W. Guddat, Esmée Gianna Knaven, Christopher Selleck, Nataša Mitić, Alice Clark, Gerhard Schenk, Marcelo Monteiro Pedroso
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Genes that confer antibiotic resistance can rapidly be disseminated from one microorganism to another by mobile genetic elements, thus transferring resistance to previously susceptible bacterial strains. The misuse of antibiotics in health care and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59e473babec157e611a0c14754988fc
Autor:
Daniel Feder, Gerhard Schenk, Luke W. Guddat, Meng-Wei Kan, Ross P. McGeary, Waleed M. Hussein
Publikováno v:
European journal of medicinal chemistry. 182
Purple acid phosphatases (PAPs) are binuclear hydrolases that catalyse the hydrolysis of phosphorylated substrates under acidic to neutral conditions. Elevated serum concentrations of PAP are observed in patients suffering from osteoporosis, identify
Autor:
Ajit Kandale, Luke W. Guddat, Gerhard Schenk, You Lv, Volker Sieber, Simon J. Williams, Bostjan Kobe, Mark A. Schembri, Ross P. McGeary, Shun Jie Wun
Publikováno v:
The FEBS Journal. 283:1184-1196
The biosynthetic pathway for the branched-chain amino acids is present in plants, fungi and bacteria, but not in animals, making it an attractive target for herbicidal and antimicrobial drug discovery. Ketol-acid reductoisomerase (KARI; EC 1.1.1.86)
Publikováno v:
The journal of physical chemistry. B. 122(22)
Glycerophosphodiesterase (GpdQ) is a binuclear metallophosphatase that catalyzes the hydrolytic cleavage of mono-, di-, and triphosphoester bonds of a wide range of critical molecules. Upon substrate binding, this enzyme undergoes a complex transform
Autor:
Tiago Pacheco, Camargo, Ademir, Neves, Rosely A, Peralta, Cláudia, Chaves, Elene C P, Maia, Edgar H, Lizarazo-Jaimes, Dawidson A, Gomes, Tiago, Bortolotto, Douglas R, Norberto, Hernán, Terenzi, David L, Tierney, Gerhard, Schenk
Publikováno v:
Inorganic chemistry. 57(1)
Herein, we report the synthesis and characterization of two dinuclear Fe
Autor:
Shan Zheng, Khushboo M. Patel, Ross P. McGeary, Mark A. Schembri, David Terán, Luke W. Guddat, Ajit Kandale, Gerhard Schenk, You Lv, Mario D. Garcia
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 23(72)
Ketol-acid reductoisomerase (KARI) is an NAD(P)H and Mg2+-dependent enzyme of the branched-chain amino acid (BCAA) biosynthesis pathway. Here we describe the first crystal structures of Staphylococcus aureus (Sa) KARI, these in complex with two trans
Autor:
Nataša Mitić, Lawrence R. Gahan, Jeffrey Harmer, Alistair J. Standish, James A. Larrabee, Christopher Selleck, Gerhard Schenk, David L. Tierney, Marcelo Monteiro Pedroso, Jessica K. Bilyj
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 46(39)
CpsB is a metal ion-dependent hydrolase involved in the biosynthesis of capsular polysaccharides in bacterial organisms. The enzyme has been proposed as a promising target for novel chemotherapeutics to combat antibiotic resistance. The crystal struc
High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase
Autor:
Gerhard Schenk, Luke W. Guddat, David L. Ollis, Marcelo Monteiro Pedroso, Christopher Selleck
Publikováno v:
Journal of inorganic biochemistry. 177
Metal ion-dependent, organophosphate-degrading enzymes (OP hydrolases) have received increasing attention due to their ability to degrade and thus detoxify commonly used pesticides and nerve agents such as sarin and VX. These enzymes thus garner stro
Autor:
Luke W. Guddat, Marcelo Monteiro Pedroso, Christopher Selleck, Gerhard Schenk, Nataša Mitić, Ross P. McGeary, Daniel Clayton, Lawrence R. Gahan
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 23(20)
Metallohydrolases are a vast family of enzymes that play crucial roles in numerous metabolic pathways. Several members have emerged as targets for chemotherapeutics. Knowledge about their reaction mechanisms and associated transition states greatly a