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Autor:
Lydia Giménez-Llort, Adolf Tobeña, Marc Guitart-Masip, Albert Fernández-Teruel, Björn Johansson
Publikováno v:
Psychopharmacology. 196:39-49
The inbred Roman high- (RHA-I) and low-avoidance (RLA-I) rats, differing in dopaminergic activity and novelty/substance-seeking profiles, may be a suitable model to study the implication of the dopaminergic system in vulnerability to drug abuse. Diff
Publikováno v:
Psychopharmacology. 119:466-473
Enhanced oral activity is induced in neonatal 6-hydroxydopamine- (6-OHDA-) lesioned rats by systemic administration of the dopamine (DA) D1 receptor agonist SKF 38393 and serotonin (5-HT) 5-HT2A,2C agonistm-chlorophenylpiperazine (m-CPP). The DA D1 r
Publikováno v:
Biochemical Pharmacology. 44:83-91
Behavioural studies suggest a functional interaction between D-1 and D-2 systems in normal rat striatum to alter motor behaviour and which is disrupted by dopamine depletion induced by acute reserpine treatment. Consequently, we have investigated the
Autor:
Xiu-Ti Hu, Francis J. White
Publikováno v:
Synapse. 10:206-216
Following 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal dopamine (DA) pathway, rat caudate-putamen (CPu) neurons are supersensitive to the inhibitory effects of both D1 and D2 dopamine (DA) receptor selective agonists. In addition, both the
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 345:153-159
The purpose of this study was to determine if the nonpeptide angiotensin II-1 receptor antagonist DuP 753 after, acute or chronic administration in vivo or after in vitro exposure, altered indices of dopaminergic function in rat striatum. In vivo stu
Autor:
Bhc Westerink, Marti Santiago
Publikováno v:
European Journal of Pharmacology, 204(1), 79-85. ELSEVIER SCIENCE BV
Drugs were infused into the substantia nigra of the rat brain via a microdialysis probe, and the extracellular concentration of dopaminc (DA) and 3,4-dihydroxyphenylacelic acid was recorded from a second dialysis probe implanted in the ipsilateral st
Autor:
Vliet Bernard J Van, Anton N. M. Schoffelmeer, Taco J. De Vries, George Wardeh, Arie H. Mulder
Publikováno v:
Van Vliet, B J, De Vries, T J, Wardeh, G, Mulder, A H & Schoffelmeer, A N M 1991, ' μ-Opioid receptor-regulated adenylate cyclase activity in primary cultures of rat striatal neurons upon chronic morphine exposure ', European Journal of Pharmacology: Molecular Pharmacology, vol. 208, no. 2, pp. 105-111 . https://doi.org/10.1016/0922-4106(91)90060-U
European Journal of Pharmacology: Molecular Pharmacology, 208(2), 105-111. Elsevier BV
European Journal of Pharmacology: Molecular Pharmacology, 208(2), 105-111. Elsevier BV
Rat striatal neurons cultured in serum-free, hormone-supplemented medium, were exposed to 10 μM morphine for several hours or days before intracellular cyclic AMP production was measured. Dopamine D1 receptor- and β-adrenoceptor-stimulated cyclic A
Autor:
Susan Benloucif, Matthew P. Galloway
Publikováno v:
European Journal of Pharmacology. 200:1-8
Using microdialysis, changes in extraneuronal levels of dopamine (DA), and the metabolites of DA and serotonin (5-HT), were monitored concurrent with perfusion of 5-HT1 agonists into the anterior striata of anesthetized rats. Perfusion of 5-HT facili
Publikováno v:
Biochemical Pharmacology. 41:2040-2043
This study provides in vitro evidence that rats pretreated with fluphenazine for 10 days, but not acutely, developed moderate but significant striatal autoreceptor supersensitivity as measured by the ability of S(+)-NPA, a selective DA autoreceptor a
Publikováno v:
European Journal of Pharmacology. 195:295-300
The beta-adrenoceptor-sensitive adenylate cyclase in primary cultures of rat striatal neurons was inhibited by opioids, unlike that in rat striatal slices. Isoprenaline (1 microM)-stimulated cyclic AMP production was dose dependently inhibited by the