Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Konak, A."'
Autor:
Milena Špírková, Cestmir Konak, Yoseph Addadi, Vladimir Subr, Twan Lammers, Libor Kostka, Karel Ulbrich, Michal Neeman
Publikováno v:
Bioconjugate Chemistry. 22:169-179
To assist in overcoming the inherent instability of nucleic acid-containing polyplexes in physiological solutions, we have here set out to develop removable nanocoatings for modifying the surface of siRNA-based nanoparticles. Here, N-(2-hydroxypropyl
Autor:
Göran Karlsson, Karel Ulbrich, Jan Kučka, Miroslav Vetrik, Sergey K. Filippov, David Vetvicka, Cestmir Konak, Hana Macková, Martin Hruby, Blanka Rihova, Katarina Edwards
Publikováno v:
Macromolecular Bioscience. 9:1016-1027
Novel polymer micelles, prepared by self-assembling thermoresponsive poly(N-isopropylacrylamide)-graft-poly[N-(2-hydroxypropyl)methacrylamide] copolymers with hydrolytically degradable N-glycosylamine groups between the polymer blocks are proposed fo
Autor:
Cestmir Konak, Miroslav Vetrik, Ondrej Lebeda, Jan Kučka, Martin Hruby, Hana Macková, Ján Kozempel
Publikováno v:
Journal of Applied Polymer Science. 111:2220-2228
Radiolabeled thermoresponsive polymers (TRPs) with cloud-point temperatures between room temperature and body temperature may have an advantage for local radiotherapeutical applications because TRPs may be isotopically labeled in solution at room tem
Publikováno v:
Macromolecular Chemistry and Physics. 209:1447-1453
Protecting gene delivery vectors by hydrophilic copolymer coating is a promising approach in targeted gene therapy. Herein we demonstrate the usefulness of FCS in characterizing the coating process of a virus model - latex beads with coumarin-labeled
Autor:
Karel Ulbrich, Cestmir Konak, Hana Macková, Ondrej Lebeda, Ján Kozempel, Martin Hruby, Martin Studenovsky, Antonín Sikora, Michal Babič, Jan Kučka
Publikováno v:
Journal of Controlled Release. 119:25-33
A new thermoresponsive system designed for local radiotherapy has been developed. In this system a radionuclide complex is entrapped in a thermoresponsive polymer locally precipitated at body temperature after injection of a polymer–complex solutio
Publikováno v:
Biomacromolecules. 7:122-130
N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymers (pHPMA) containing 4-nitrophenyl ester (ONp) or thiazolidine-2-thione (TT) reactive groups in side chains and telechelic/semitelechelic pHPMA with TT groups were designed as highly hydrophilic bioco
Publikováno v:
Macromolecular Bioscience. 3:425-435
Self-assembling system based on ionic complexes of DNA fragments (36 base pairs), bcl-2 antisense oligonucleotides (octadecamer), oligophosphates (25 phosphate groups) or acrylic oligomers (18 groups of phosphonic acid) with poly(L-lysine) (PLL) (M w
Publikováno v:
Journal of Polymer Science Part B: Polymer Physics. 40:2807-2816
We have examined solutions of a polystyrene–polybutadiene pentablock copolymer in 1,4-dioxane, a slightly selective solvent for polystyrene and a θ solvent for polybutadiene, with static light scattering (SLS), dynamic light scattering (DLS), and
Publikováno v:
Langmuir. 18:8217-8222
The effect of temperature on the association of graft copolymers of poly(l-lysine)-graft-poly(N-isopropylacrylamide), PLL-g-PNIPAM, in water was investigated by light scattering methods and electron microscopy. It was found that the thermosensitive g
Publikováno v:
Langmuir. 17:3096-3102
Self-assembling systems based on ionic complexes of oligonucleotides (36 base pairs) and model oligophosphates (polymerization degree of 35) with high molecular poly(l-lysine) molecules (Mw = 134 0...