Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Stephen H. Bryant"'
Publikováno v:
Slas Discovery
High-throughput screening (HTS) is now routinely conducted for drug discovery by both pharmaceutical companies and screening centers at academic institutions and universities. Rapid advance in assay development, robot automation, and computer technol
Autor:
Stephen H. Bryant, Dachuan Zhang, Yanli Wang, Philippe Youkharibache, Renata C. Geer, Christopher J. Lanczycki, Gabriele H. Marchler, Lewis Y. Geer, Jiyao Wang, Lon Phan, Shennan Lu, Thomas Madej, Minghong Ward, Aron Marchler-Bauer
SummaryiCn3D (I-see-in-3D) is a web-based 3D molecular structure viewer focusing on the interactive structural analysis. It can simultaneously show 3D structure, 2D molecular contacts, and 1D protein and nucleotide sequences through an integrated seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e83e8d76416eff56cc2e4bf864aab7
https://doi.org/10.1101/501692
https://doi.org/10.1101/501692
While novel technologies such as high-throughput screening have advanced together with significant investment by pharmaceutical companies during the past decades, the success rate for drug development has not yet been improved prompting researchers l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b20b2a7041a66c8e42633897084b981
https://europepmc.org/articles/PMC6781586/
https://europepmc.org/articles/PMC6781586/
Autor:
James S. Song, Yu Bo, Narmada Thanki, Dachuan Zhang, Zhouxi Wang, Jane He, Myra K. Derbyshire, Roxanne A. Yamashita, Stephen H. Bryant, Farideh Chitsaz, Noreen R. Gonzales, Lianyi Han, Lewis Y. Geer, Aron Marchler-Bauer, Chanjuan Zheng, Christopher J. Lanczycki, Marc Gwadz, Renata C. Geer, Fu Lu, Gabriele H. Marchler, Shennan Lu, David I. Hurwitz
Publikováno v:
Nucleic Acids Research
NCBI's Conserved Domain Database (CDD) aims at annotating biomolecular sequences with the location of evolutionarily conserved protein domain footprints, and functional sites inferred from such footprints. An archive of pre-computed domain annotation
Autor:
Renata C. Geer, Aron Marchler-Bauer, Paul A. Thiessen, Christopher J. Lanczycki, Stephen H. Bryant, Dachuan Zhang, Thomas Madej
Publikováno v:
Nucleic Acids Research
The computational detection of similarities between protein 3D structures has become an indispensable tool for the detection of homologous relationships, the classification of protein families and functional inference. Consequently, numerous algorith
Autor:
David I. Hurwitz, Christopher J. Lanczycki, Noreen R. Gonzales, Stephen H. Bryant, Farideh Chitsaz, James S. Song, Marc Gwadz, Gabriele H. Marchler, Narmada Thanki, Lewis Y. Geer, Dachuan Zhang, Renata C. Geer, Fu Lu, Chanjuan Zheng, Roxanne A. Yamashita, Myra K. Derbyshire, Aron Marchler-Bauer, Shennan Lu
Publikováno v:
Nucleic Acids Research
CDD, the Conserved Domain Database, is part of NCBI’s Entrez query and retrieval system and is also accessible via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml. CDD provides annotation of protein sequences with the location of conserved doma
Publikováno v:
Journal of Molecular Biology. 415(2):443-453
The modulation of protein–protein interactions (PPIs) by small drug-like molecules is a relatively new area of research and has opened up new opportunities in drug discovery. However, the progress made in this area is limited to a handful of known
Autor:
Ratna R. Thangudu, Aron Marchler-Bauer, Jessica H. Fong, Dachuan Zhang, Anna R. Panchenko, Manoj Tyagi, Benjamin A. Shoemaker, Thomas Madej, Stephen H. Bryant
Publikováno v:
Nucleic Acids Research
We have recently developed the Inferred Biomolecular Interaction Server (IBIS) and database, which reports, predicts and integrates different types of interaction partners and locations of binding sites in proteins based on the analysis of homologous
Autor:
Chunlei Liu, Renata C. Geer, Kenneth J. Addess, Anna R. Panchenko, Lewis Y. Geer, Thomas Madej, Stephen H. Bryant, Aron Marchler-Bauer, Christopher J. Lanczycki, Shennan Lu, Jie Chen, Jessica H. Fong, Dachuan Zhang, Yanli Wang, Paul A. Thiessen
Publikováno v:
Nucleic Acids Research
Close to 60% of protein sequences tracked in comprehensive databases can be mapped to a known three-dimensional (3D) structure by standard sequence similarity searches. Potentially, a great deal can be learned about proteins or protein families of in
Publikováno v:
Journal of Chemical Information and Modeling
Aqueous solubility is recognized as a critical parameter in both the early- and late-stage drug discovery. Therefore, in silico modeling of solubility has attracted extensive interests in recent years. Most previous studies have been limited in using