Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alfredo Castello"'
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Autor:
Natasha Johnson, Berati Cerikan, Shabaz Mohammed, Manuel Garcia-Moreno, Javier Martinez, Christopher J. Neufeldt, Alfredo Castello, Ralf Bartenschlager, Mohamed Kammoun, Jeffrey Y. Lee, Anna Andrejeva, Mirko Cortese, Marko Noerenberg, Honglin Chen, Kathryn S. Lilley, Ilan Davis, Michael L. Knight, Aino I. Järvelin, Ni Shuai, Wael Kamel, Michael J. Deery
Publikováno v:
Molecular Cell
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control its life cycle remains largely unknown. Here, we employ a mul
Autor:
Natasha Palmalux, Shabaz Mohammed, Louisa Iselin, Wael Kamel, Peter Simmonds, Alfredo Castello
Publikováno v:
trends in biochemical sciences
RNA viruses interact with a wide range of cellular RNA-binding proteins (RBPs) during their life cycle. The prevalence of these host-virus interactions has been highlighted by new methods that elucidate the composition of viral ribonucleoproteins (vR
Autor:
Ralf Bartenschlager, Alfredo Castello, Jeffrey Y. Lee, Berati Cerikan, Ilan Davis, Christopher J. Neufeldt, Honglin Chen, Manuel Garcia-Moreno, Javier Martinez, Kathryn S. Lilley, Anna Andrejeva, Michael J. Deery, Marko Noerenberg, Mirko Cortese, Wael Kamel, Michael L. Knight, Ni Shuai, Aino I. Järvelin, Mohamed Kammoun, Shabaz Mohammed
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control SARS-CoV-2 infection remains largely unknown. Here, we employ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4faa151542462c893b9464395431018
https://doi.org/10.1101/2020.11.25.398008
https://doi.org/10.1101/2020.11.25.398008
Publikováno v:
Seminars in Cell & Developmental Biology
Highlights • Proteomic studies have uncovered more than a thousand cellular proteins that are present in the particles of RNA viruses. • Strikingly, nearly four hundred of these are RNA-binding proteins (RBPs). • Several virion-incorporated RBP
Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method
Autor:
Felix Homma, Shabaz Mohammed, Markus Kaiser, Marcel Bach-Pages, Renier A. L. van der Hoorn, Alfredo Castello, Farnusch Kaschani, Gail M. Preston, Jiorgos Kourelis
Publikováno v:
Biomolecules
Biomolecules, Vol 10, Iss 661, p 661 (2020)
Volume 10
Issue 4
Biomolecules, Vol 10, Iss 661, p 661 (2020)
Volume 10
Issue 4
RNA-binding proteins (RBPs) play a crucial role in regulating RNA function and fate. However, the full complement of RBPs has only recently begun to be uncovered through proteome-wide approaches such as RNA interactome capture (RIC). RIC has been app
Autor:
Caroline E. Lenz, Matthias W. Hentze, Joel I. Perez-Perri, Marko Noerenberg, Shabaz Mohammed, Alfredo Castello, Wael Kamel
Publikováno v:
Nat Protoc
Interactions between RNA-binding proteins (RBPs) and RNAs are critical to cell biology. However, methods to comprehensively and quantitatively assess these interactions within cells were lacking. RNA interactome capture (RIC) uses in vivo UV crosslin
Autor:
Svenja Hester, Krzysztof Kus, Cornelia Kilchert, Emily Priest, Ebru Aydin, Lidia Vasiljeva, Alfredo Castello, Oliver Rossbach, Tea Kecman, Shabaz Mohammed
Large RNA-binding complexes play a central role in gene expression and orchestrate production, function, and turnover of mRNAs. The accuracy and dynamics of RNA–protein interactions within these molecular machines are essential for their function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ef71188ccb20b10ec41d6dd22f34bb
https://doi.org/10.1101/748194
https://doi.org/10.1101/748194
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) and change the fate or function of the bound RNAs. Several hundred such RBPs have been discovered and investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b673698addb260e76982715b9b2c4fc
https://eprints.gla.ac.uk/219002/1/219002.pdf
https://eprints.gla.ac.uk/219002/1/219002.pdf
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
Autor:
Evangelos Christodoulou, Andres Ramos, Roksana W. Ogrodowicz, André Dallmann, Cecilia Battistelli, Fruzsina Hobor, Ian A. Taylor, Stephen R. Martin, Neil J. Ball, Marco Tripodi, Alfredo Castello, Carla Cicchini
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, 9, Article 831. (2018)
UCL Discovery
Oxford University Research Archive
PubMed Central
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, 9, Article 831. (2018)
UCL Discovery
Oxford University Research Archive
PubMed Central
Exosomal miRNA transfer is a mechanism for cell–cell communication that is important in the immune response, in the functioning of the nervous system and in cancer. Syncrip/hnRNPQ is a highly conserved RNA-binding protein that mediates the exosomal