Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Weiping Zou"'
Autor:
Danfeng Sun, Weichao Wang, Fangfang Guo, Michael R. Pitter, Wan Du, Shuang Wei, Sara Grove, Linda Vatan, Yingxuan Chen, Ilona Kryczek, Eric R. Fearon, Jing-Yuan Fang, Weiping Zou
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Chronic inflammation and oncogenic pathway activation are key-contributing factors in colorectal cancer pathogenesis. However, colorectal intrinsic mechanisms linking these two factors in cancer development are poorly defined. Here, we show that inte
Externí odkaz:
https://doaj.org/article/b15ed1fa7f02475197f41ee424609607
Publikováno v:
Cellular and Molecular Immunology
The majority of colorectal cancer patients are not responsive to immune checkpoint blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and ICB-induced antitumor immunity. In this review, we summarize recent advances in t
Autor:
Linda Vatan, Weiping Zou, Yijian Yan, Weichao Wang, Gaopeng Li, Xiong Li, Jiajia Zhou, Shuang Wei, Grzegorz Wallner, Weimin Wang, Marek Majewski, Wan Du, Jian Zhang, Shasha Li, Sara Grove, Haoyan Chen, Fang Hua, Witold Zgodziński, Jing-Yuan Fang, Peng Liao, Ilona Kryczek
Publikováno v:
Cancer Discovery. 11:1826-1843
Mutations in IFN and MHC signaling genes endow immunotherapy resistance. Patients with colorectal cancer infrequently exhibit IFN and MHC signaling gene mutations and are generally resistant to immunotherapy. In exploring the integrity of IFN and MHC
Autor:
Weiping Zou, Junfang Zhang, Jinxian Chen, Dan Ma, Jie Hong, Tingting Yan, Chaoqin Shen, Haoyan Chen, Qiang Liu, Danfeng Sun, Wan Du, Ming Zhong, Fangfang Guo, Ying-Xuan Chen, Yuan-Hong Xie, Xianglong Tian, Ji-Xuan Han, Penglei Jiang, Jing-Yuan Fang, Chenyang Yu, Ye Hu, Xiaoqiang Zhu, Jiayin Tang
Publikováno v:
Oncogene
Genome-wide association studies (GWASs) implicate 16q22.1 locus in risk for colorectal cancer (CRC). However, the underlying oncogenic mechanisms remain unknown. Here, through comprehensive filtration, we prioritized rs7198799, a common SNP in the se
Autor:
Qian Liang, Haoyan Chen, Chenyang Yu, Yujie Bao, Jiayin Tang, Jinxian Chen, Weiping Zou, Fangfang Guo, Xiaoqiang Zhu, Xiao-Bo Li, Xianglong Tian, Tingting Yan, Jie Hong, Ming Zhong, Xiaoyu Chen, Jing-Yuan Fang, Ying-Xuan Chen, Chaoqin Shen, Qiang Liu, Zhi-Zheng Ge, Yun Cui
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulate
Autor:
Jian Zhang, Marek Majewski, Shanshan Qi, Lin Wang, Weiping Zou, Stanislaw Gozdz, Pawel Macek, Artur Kowalik, Ewelina Grywalska, Marcin Pasiarski, Lili Zhao, Guobin Wang, Grzegorz Wallner, Yongkui Li, Zheng Wang, Fang Min, Linda Vatan, Kai Huang, Wei Li, Nisha Nagarsheth, Ilona Kryczek, Witold Zgodziński
Publikováno v:
Cancer Research. 77:2735-2745
The expression and biological role of IL33 in colon cancer is poorly understood. In this study, we show that IL33 is expressed by vascular endothelial cells and tumor cells in the human colon cancer microenvironment. Administration of human IL33 and
Autor:
Morgan Oneka, J. Joshua Smith, Arvind Rao, Marina Pasca di Magliano, Mirna Perusina Lanfranca, Jiaqi Shi, Jiayun M Fang, Jinru Shia, Weiping Zou, Tomasz Maj, Lei Sun, Souptik Barua, Jenny Lazarus, Timothy L. Frankel, Michael I. D’Angelica, Lawrence Delrosario
Publikováno v:
Annals of surgical oncology. 26(9)
Although immune-based therapy has proven efficacious for some patients with microsatellite instability (MSI) colon cancers, a majority of patients receive limited benefit. Conversely, select patients with microsatellite stable (MSS) tumors respond to
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 108:e539
Autor:
Jinru Shia, Isaac Wasserman, J. Joshua Smith, Mirna Perusina Lanfranca, Arvind Rao, Casey Schukow, Howard C. Crawford, Marina Pasca di Magliano, Jiaqi Shi, Alexander Girgis, Hari Nathan, Jenny Lazarus, Lawrence Delrosario, Timothy L. Frankel, Tomasz Maj, Michael I. D’Angelica, Weiping Zou, Ilona Kryczek
Publikováno v:
JCI insight. 3(22)
Paramount to the efficacy of immune checkpoint inhibitors is proper selection of patients with adequate tumor immunogenicity and a robust but suppressed immune infiltrate. In colon cancer, immune-based therapies are approved for patients with DNA mis
Autor:
Jiayin Tang, Lin-Lin Ren, Ilona Kryczek, Jie Hong, Haoyan Chen, Weiping Zou, Danfeng Sun, Ming Zhong, Tingting Yan, Qian Liang, Witold Zgodziński, Zhenhua Wang, Jinxian Chen, Chaoqin Shen, Qiang Liu, Marek Majewski, Jing-Yuan Fang, Piotr Radwan, Ying-Xuan Chen, Ya-Nan Yu
Publikováno v:
Cancer research. 78(7)
Colorectal cancer includes an invasive stem-like/mesenchymal subtype, but its genetic drivers, functional, and clinical relevance are uncharacterized. Here we report the definition of an altered miRNA signature defining this subtype that includes a m