Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mengxiao Yu"'
Publikováno v:
Nano Lett
Fundamental understandings and precise control of nanoparticle growth in the complex biological environment are crucial to broadening their potential applications in tissue imaging. Herein, we report that glutathione (GSH), a widely used capping liga
Publikováno v:
Angewandte Chemie International Edition. 58:12076-12080
Enhancing tumor targeting of nanocarriers has been a major strategy for advancing clinical translation of cancer nanomedicines. Herein, we report a head-to-head comparison between 5 nm renal clearable and 30 nm non-renal clearable gold nanoparticle (
Publikováno v:
Angewandte Chemie. 131:12204-12208
Publikováno v:
Angewandte Chemie International Edition. 58:4112-4128
With more and more engineered nanoparticles (NPs) being translated to the clinic, the United States Food and Drug Administration (FDA) has recently issued the latest draft guidance on nanomaterial-containing drug products with an emphasis on understa
Autor:
Andrew Dang, Mengxiao Yu, Elizabeth Hernandez, Jer Tsong Hsieh, Payal Kapur, Phoebe Carter, Jing Xu, Jie Zheng
Publikováno v:
Angewandte Chemie International Edition. 56:13356-13360
With more and more engineered nanoparticles (NPs) being designed renal clearable for clinical translation, fundamental understanding of their transport in the different compartments of kidneys becomes increasingly important. Here, we report noninvasi
Autor:
Jie Zheng, Julia D. Hankins, Shasha Sun, Li Liu, Mengxiao Yu, Xiankai Sun, Chen Zhou, Shanrong Zhang
Publikováno v:
Angewandte Chemie. 129:4378-4383
The success of nanomedicines in the clinic depends on our comprehensive understanding of nano-bio interactions in tumor microenvironments, which are characterized by dense leaky microvasculature and acidic extracellular pH (pHe ) values. Herein, we i
Autor:
Bujie Du, Jie Zheng, Jer Tsong Hsieh, Payal Kapur, Jing Xu, Chuanqi Peng, Yingyu Huang, Elizabeth Hernandez, Xuhui Ning, Mengxiao Yu
Publikováno v:
Angew Chem Int Ed Engl
Precise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to future successes of cancer nanomedicines in clinics, which demands us to fundamentally understand how engineered nanopart
Autor:
Phoebe Carter, Xudong Zhao, Qinhan Zhou, Xuhui Ning, Qiu Tu, Jer Tsong Hsieh, Payal Kapur, Greg Zhang, Jing Xu, Jie Zheng, Chuanqi Peng, Jia Tian, Xingya Jiang, Anthony Dao, Mengxiao Yu, Pengyu Liu
Publikováno v:
Angewandte Chemie (International ed. in English). 57(1)
While dose dependencies in pharmacokinetics and clearance are often observed in clinically used small molecules, very few studies have been dedicated to the understandings of potential dose-dependent in vivo transport of nanomedicines. Here we report
Autor:
Shasha Sun, Jie Zheng, Rodrigo D. Vinluan, Chen Zhou, Jinbin Liu, Andrew Dean, Amit Kumar, Mengxiao Yu, Shengyang Yang, Xiankai Sun
Publikováno v:
ACS Applied Materials & Interfaces
Ultrasmall glutathione-coated luminescent gold nanoparticles (GS-AuNPs) are known for their high resistance to serum protein adsorption. Our studies show that these NPs can serve as surface ligands to significantly enhance the physiological stability
Publikováno v:
Experimental Biology and Medicine. 238:1199-1209
Our fundamental understanding of cell biology and early diagnosis of human diseases have been greatly benefited from the development of fluorescent probes. Over the past decade, luminescent gold nanoparticles (AuNPs) with diverse structural parameter