Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jonathan L.C. Lee"'
Publikováno v:
Learn Mem
The efficacy of pharmacological disruption of fear memory reconsolidation depends on several factors, including memory strength and age. We built on previous observations that systemic treatment with the nootropic nefiracetam potentiates cued fear me
Publikováno v:
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Reconsolidation normally functions to update and maintain memories in the long-term. However, this process can be disrupted pharmacologically to weaken memories. Exploiting such experimental amnesia to disrupt the maladaptive reward memories underpin
Publikováno v:
Trends in Cognitive Sciences. 21:531-545
The reactivation of a synaptically stored memory in the brain can make the memory transiently labile. During the time it takes for the memory to re-stabilize (reconsolidate), the memory can either be reduced by an amnesic agent or enhanced by memory
Publikováno v:
Neurobiology of Learning and Memory. 104:25-31
When memories are retrieved, they can enter a labile state during which the memory may be modified and subsequently restabilized through the process of reconsolidation. However, this does not occur in all situations, and certain "boundary conditions"
Autor:
Amy C. Reichelt, Jonathan L.C. Lee
Publikováno v:
Learning & Memory. 20:51-60
Despite extensive evidence that appetitive memories undergo reconsolidation, two notable failures to observe reconsolidation have been reported: instrumental responding and goal-tracking. However, these studies do not provide conclusive evidence for
Autor:
Jonathan L.C. Lee, Robert E. Hynds
Publikováno v:
Hippocampus. 23:233-244
The reconsolidation of memories after their retrieval involves cellular mechanisms that recapitulate much of the initial consolidation process. However, we have previously demonstrated that there are independent cellular mechanisms of consolidation a
Publikováno v:
Learning & Memory. :256-263
The basolateral amygdala (BLA) and the dorsal hippocampus (dHPC) are both structures with key roles in contextual fear conditioning. During fear conditioning, it is postulated that contextual representations of the environment are formed in the hippo
Publikováno v:
Learn Mem
Learn Mem, 2010, 17 (9), pp.444-53. ⟨10.1101/lm.1757410⟩
Learn Mem, 2010, 17 (9), pp.444-53. ⟨10.1101/lm.1757410⟩
A distributed limbic-corticostriatal circuitry is implicated in cue-induced drug craving and relapse. Exposure to drug-paired cues not only precipitates relapse, but also triggers the reactivation and reconsolidation of the cue-drug memory. However,
Autor:
Jonathan L.C. Lee, Barry J. Everitt
Publikováno v:
Learning & Memory. 15:597-602
The theory of memory reconsolidation relates to the hypothesized restabilisation process that occurs following the reactivation of a memory through retrieval. Thus the demonstration of reactivation-dependent amnesia for a previously acquired memory i
Autor:
Barry J. Everitt, Jonathan L.C. Lee
Publikováno v:
Neurobiology of Learning and Memory. 90:147-154
Memory persistence is a dynamic process involving the reconsolidation of memories after their reactivation. Reconsolidation impairments have been demonstrated for many types of memories in rats, and signaling at N -methyl- d -aspartate (NMDA) recepto