Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Catherine L. Drennan"'
Autor:
Maanasa Narayanamoorthy, Chaoxiang Ren, Antonio Del Rio Flores, Jan Paulo T. Zaragoza, Wenjun Zhang, Heather J. Kulik, Wenlong Cai, Rimsha Mehmood, Rohan Jonnalagadda, Catherine L. Drennan
Publikováno v:
The Journal of Biological Chemistry
Elsevier
Elsevier
The isonitrile moiety is found in marine sponges and some microbes, where it plays a role in processes such as virulence and metal acquisition. Until recently only one route was known for isonitrile biosynthesis, a condensation reaction that brings t
Publikováno v:
The Journal of Biological Chemistry
Pyruvate formate-lyase (PFL) is a glycyl radical enzyme (GRE) that converts pyruvate and coenzyme A into acetyl-CoA and formate in a reaction that is crucial to the primary metabolism of many anaerobic bacteria. The glycyl radical cofactor, which is
Autor:
Emily P. Balskus, Ronald T. Raines, Mary C. Andorfer, Catherine L. Drennan, Lindsey R. F. Backman, Yolanda Y. Huang, Brian Gold
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was d
Publikováno v:
Journal of Biological Chemistry. 293:10404-10412
Ribonucleotide reductases (RNRs) convert ribonucleotides to deoxynucleotides, a process essential for DNA biosynthesis and repair. Class Ia RNRs require two dimeric subunits for activity: an α2 subunit that houses the active site and allosteric regu
Publikováno v:
Proceedings of the National Academy of Sciences. 115:3846-3851
Pyruvate:ferredoxin oxidoreductase (PFOR) is a microbial enzyme that uses thiamine pyrophosphate (TPP), three [4Fe-4S] clusters, and coenzyme A (CoA) in the reversible oxidation of pyruvate to generate acetyl-CoA and carbon dioxide. The two electrons
Publikováno v:
Nature
Oxetanocin A (OXT-A) is a potent antitumour, antiviral and antibacterial compound. Biosynthesis of OXT-A has been linked to a plasmid-borne Bacillus megaterium gene cluster that contains four genes: oxsA, oxsB, oxrA and oxrB. Here we show that both t
Publikováno v:
Annual review of biochemistry. 87
S-adenosylmethionine (AdoMet) has been referred to as both “a poor man's adenosylcobalamin (AdoCbl)” and “a rich man's AdoCbl,” but today, with the ever-increasing number of functions attributed to each cofactor, both appear equally rich and
Publikováno v:
The FASEB Journal. 32
Publikováno v:
Biochemistry
The soil actinomycete Kutzneria sp. 744 produces a class of highly decorated hexadepsipeptides, which represent a new chemical scaffold that has both antimicrobial and antifungal properties. These natural products, known as kutznerides, are created v
Publikováno v:
Proceedings of the National Academy of Sciences. 111:10161-10166
Anaerobic degradation of the environmental pollutant toluene is initiated by the glycyl radical enzyme benzylsuccinate synthase (BSS), which catalyzes the radical addition of toluene to fumarate, forming benzylsuccinate. We have determined crystal st