Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Eudocia Q. Lee"'
Autor:
Eudocia Q. Lee
Publikováno v:
Journal of Neuro-Oncology. 155:1-11
The purpose of this review is to summarize recent updates regarding immune checkpoint inhibitor therapy in GBM patients including updates in brain immunology, clinical trials, mechanisms of resistance, and biomarkers of response. PubMed was searched
Autor:
Rifaquat Rahman, Minesh P. Mehta, David A. Reardon, Louis B. Nabors, Timothy F. Cloughesy, John Sampson, Evanthia Galanis, Susan M. Chang, Roger Stupp, Mustafa Khasraw, Eudocia Q. Lee, Shawn Kothari, Manmeet S Ahluwalia, Stephen J Bagley, Patrick Y. Wen, Stuart A. Grossman, Simon Khagi, Erik P. Sulman, Michael Weller, Gavin P. Dunn
Publikováno v:
Clin Cancer Res
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 4
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 4
Therapeutic advances for glioblastoma have been minimal over the past 2 decades. In light of the multitude of recent phase III trials that have failed to meet their primary endpoints following promising preclinical and early-phase programs, a Society
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612f47b9746bfe62bd08464f5d6d027d
https://europepmc.org/articles/PMC9044253/
https://europepmc.org/articles/PMC9044253/
Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis
Autor:
Daniel P. Cahill, Scott L. Carter, Nan Lin, Brian V. Nahed, Jorg Dietrich, Ugonma Chukwueke, Ian E. Krop, Christopher Alvarez-Breckenridge, Nancy Wang, Anita Giobbie-Hurder, Maura Mahar, Beverly Moy, Priscilla K. Brastianos, Justine V. Cohen, Mia Bertalan, Deborah Forst, Michael White, Tracy T. Batchelor, Sara M. Tolaney, Brian A. Shaw, Donald P. Lawrence, Lakshmi Nayak, Helen A. Shih, Kevin S. Oh, Nathaniel Goss, Naema Nayyar, Albert H. Kim, Ryan J. Sullivan, Elizabeth R. Gerstner, Megha Subramanian, Joana L. Mora, Eudocia Q. Lee
Publikováno v:
Nature Medicine. 26:1280-1284
An increasing fraction of patients with metastatic cancer develop leptomeningeal dissemination of disease (LMD), and survival is dismal1–3. We conducted a single-arm, phase 2 study of pembrolizumab in patients with solid tumor malignancies and LMD
Autor:
Giorgio Gaglia, Ziming Du, Louis B. Nabors, Yang Dai, Ishwar N. Kohale, Ilya Korsunsky, Brian M. Alexander, Jann N. Sarkaria, Eudocia Q. Lee, Patrick Y. Wen, Michael S. Regan, Sankha S. Basu, Soumya Raychaudhuri, Elizabeth C. Randall, Keith L. Ligon, Bianca-Maria Marin, Forest M. White, Ann C. Mladek, Sandro Santagata, Nathalie Y. R. Agar, Stuart A. Grossman, Danielle M. Burgenske, Jeffrey G. Supko, Jeffrey N. Agar, Amanda R Clark, Sylwia A. Stopka, Walid M. Abdelmoula, Begoña Gimenez-Cassina Lopez
Publikováno v:
Neuro Oncol
Background Response to targeted therapy varies between patients for largely unknown reasons. Here, we developed and applied an integrative platform using mass spectrometry imaging (MSI), phosphoproteomics, and multiplexed tissue imaging for mapping d
Autor:
Eudocia Q. Lee
Publikováno v:
Current Treatment Options in Oncology
Opinion statement Clinical trials play a critical role in discovering new treatments, but the path to regulatory approval can be cumbersome and time consuming. Efforts to increase the efficiency and interpretability of clinical trials within the neur
Autor:
Chitkala Kalidas, W. K. Alfred Yung, Andrew B. Lassman, John de Groot, David Arons, Joseph C. Kvedar, Mustafa Khasraw, Susan M. Chang, Clair Meehan, Lee H. Schwamm, Mary Welch, Jeffrey A. Bacha, Erik Bloomquist, Solmaz Sahebjam, Wendy Selig, Patrick Y. Wen, Evanthia Galanis, Vinay K. Puduvalli, Amy Barone, Gelareh Zadeh, Islam Hassan, Eudocia Q. Lee, Sharon Tamir
Publikováno v:
Neuro-Oncology
On July 24, 2020, a workshop sponsored by the National Brain Tumor Society was held on innovating brain tumor clinical trials based on lessons learned from the COVID-19 experience. Various stakeholders from the brain tumor community participated incl
Autor:
Brian M. Alexander, G.C. Youssef, Patrick Y. Wen, David A. Reardon, Ugonma Chukwueke, J.R. McFaline-Figueroa, Diana D. Shi, Eudocia Q. Lee, Wenya Bi, Shyam K. Tanguturi, S. Whorral, Daphne A. Haas-Kogan, Lakshmi Nayak, Rifaquat Rahman, Daniel N. Cagney, M. Allen, Rameen Beroukhim, Ayal A. Aizer, Keith L. Ligon, Mary Jane Lim-Fat
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 111:e598-e599
PURPOSE/OBJECTIVE(S) While glioblastoma (GBM) is known to have increased incidence in males, recent work has identified possible sex-specific molecular differences that could be associated with improved clinical outcomes for female GBM patients. We e
Autor:
Patrick Y. Wen, Eudocia Q. Lee
Publikováno v:
ESMO Open
ESMO Open, Vol 5, Iss Suppl 4 (2020)
ESMO Open, Vol 5, Iss Suppl 4 (2020)
The study population within phase III clinical trials leading to approval of new cancer agents should ideally more closely mirror the population who will ultimately receive these agents. Although the number of females participating in clinical trials
Autor:
Patrick Roth, Jill S. Barnholtz-Sloan, Marc Sanson, Jonathan Tsang, Tracy T. Batchelor, Ingo K. Mellinghoff, Minesh P. Mehta, Kenneth Aldape, Martin J B Taphoorn, Floris P. Barthel, Ranjit S. Bindra, Emilie Le Rhun, David Nathanson, Matthias Preusser, David A. Reardon, Michael Platten, Susan M. Chang, Brian M. Alexander, Andreas von Deimling, Martin J. van den Bent, Andrew B. Lassman, Craig Horbinski, Gelareh Zadeh, Roel G.W. Verhaak, E. Antonio Chiocca, Evanthia Galanis, Susan C Short, Eudocia Q. Lee, Patrick Y. Wen, John DeGroot, Raymond Y. Huang, Michael Weller, Mark R. Gilbert, Joerg C. Tonn, Wolfgang Wick, Monika E. Hegi, David Schiff, Michael Lim, Giuseppe Minniti, Timothy F. Cloughesy
Publikováno v:
Neuro Oncol
Neuro-oncology, vol 22, iss 8
Neuro-Oncology
Neuro-Oncology, Oxford University Press (OUP), 2020, 22 (8), pp.1073-1113. ⟨10.1093/neuonc/noaa106⟩
Neuro-Oncology, 22(8), 1073-1113. OXFORD UNIV PRESS INC
Neuro-Oncology, 2020, 22 (8), pp.1073-1113. ⟨10.1093/neuonc/noaa106⟩
Neuro-Oncology, 22(8), 1073-1113. Oxford University Press
Neuro-oncology, vol 22, iss 8
Neuro-Oncology
Neuro-Oncology, Oxford University Press (OUP), 2020, 22 (8), pp.1073-1113. ⟨10.1093/neuonc/noaa106⟩
Neuro-Oncology, 22(8), 1073-1113. OXFORD UNIV PRESS INC
Neuro-Oncology, 2020, 22 (8), pp.1073-1113. ⟨10.1093/neuonc/noaa106⟩
Neuro-Oncology, 22(8), 1073-1113. Oxford University Press
Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5974a0e3a1762a5ebbce520823ecdb62
https://europepmc.org/articles/PMC7594557/
https://europepmc.org/articles/PMC7594557/
Autor:
Mikael L. Rinne, Patrick Y. Wen, David A. Reardon, Prashin Unadkat, Lais Cabrera, Sylvia Kurz, Lakshmi Nayak, Eudocia Q. Lee, David Hastie, Raymond Y. Huang
Publikováno v:
Neurology. 91:e1355-e1359
ObjectiveTo investigate the question of whether salvage therapy with the programmed cell death protein 1 (PD-1)–blocking antibodies nivolumab or pembrolizumab with or without bevacizumab offers clinical or survival benefit in patients with recurren