Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Preclinical research"'
Autor:
Lars Walløe, Thomas R. Wood, Mari Falck, Marianne Thoresen, Damjan Osredkar, Hemmen Sabir, Else Marit Løberg, Julia Kristine Gundersen, Elke Maes
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Wood, T R, Gundersen, J, Falck, M, Maes, E P J, Osredkar, D, Løberg, E M, Sabir, H, Walløe, L & Thoresen, M 2020, ' Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic-ischaemic brain injury : a single laboratory meta-analysis ', Scientific Reports, vol. 10, 10833 . https://doi.org/10.1038/s41598-020-67532-2
Scientific Reports
Wood, T R, Gundersen, J, Falck, M, Maes, E P J, Osredkar, D, Løberg, E M, Sabir, H, Walløe, L & Thoresen, M 2020, ' Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic-ischaemic brain injury : a single laboratory meta-analysis ', Scientific Reports, vol. 10, 10833 . https://doi.org/10.1038/s41598-020-67532-2
Therapeutic hypothermia (HT) is standard care for term infants with hypoxic–ischaemic (HI) encephalopathy. However, the efficacy of HT in preclinical models, such as the Vannucci model of unilateral HI in the newborn rat, is often greater than that
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of
Autor:
Philippe De La Rochere, Didier Decaudin, Sukhvinder S. Sidhu, Eliane Piaggio, Silvia Guil-Luna, Georges A. Azar
Publikováno v:
Trends in Immunology. 39:748-763
Immunotherapy is revolutionizing cancer treatment; however, complete responses are achieved in only a small fraction of patients and tumor types. Thus, there is an urgent need for predictive preclinical models to drive rational immunotherapeutic drug
Autor:
Mitra J. Hooshmand, Hongli Liu, Aileen J. Anderson, Rebecca A. Nishi, Dana Creasman, Anna Badner
Publikováno v:
PLoS ONE
PloS one, vol 15, iss 6
PLoS ONE, Vol 15, Iss 6, p e0234245 (2020)
PloS one, vol 15, iss 6
PLoS ONE, Vol 15, Iss 6, p e0234245 (2020)
There are approximately 1.2 million people currently living with spinal cord injury (SCI), with a majority of cases at the cervical level and half involving incomplete injuries. Yet, as most preclinical research has been focused on bilateral thoracic
Publikováno v:
Acta Neuropathologica. 134:679-689
Medulloblastoma is the most frequent malignant brain tumor in childhood, but it may also affect infants, adolescents, and young adults. Recent advances in the understanding of the disease have shed light on molecular and clinical heterogeneity, which
Autor:
Tuuli M Hietamies, Christopher McCabe, Terence J. Quinn, Lorraine M. Work, Luyang Feng, Zhong Pei, Caroline Ostrowski
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 38(11)
Despite promising preclinical data, few novel stroke therapies have shown efficacy in man. Efforts to improve standards in conduct and reporting of preclinical research are ongoing. In clinical trials, inconsistency in outcome measures led to regulat
Publikováno v:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 14(2)
The development and application of rodent models for preclinical testing of novel therapeutics and approaches for treating brain tumors has been a mainstay of neuro-oncology preclinical research for decades, and is likely to remain so into the forese
Autor:
Alex John London, Jonathan Kimmelman
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, Vol 4 (2015)
The high rates of attrition that occur in drug development are widely regarded as problematic, but the failure of well-designed studies benefits both researchers and healthcare systems by, for example, generating evidence about disease theories and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544ffc430bfcd6b0cb48643fce74c4a9
Autor:
Eric C. Donny, Rachel L Denlinger-Apte, Laura E. Rupprecht, Alan F. Sved, Rachel S Panas, Jillian J Weeks, Tracy T. Smith
Publikováno v:
Nicotinetobacco research : official journal of the Society for Research on Nicotine and Tobacco. 19(9)
A mandated reduction in the nicotine content of cigarettes may improve public health by reducing the prevalence of smoking. Animal self-administration research is an important complement to clinical research on nicotine reduction. It can fill researc
Autor:
George W. Korch, Karl J. Erlandson, Jean Hu-Primmer, Armen Donabedian, Michael O’Hara, Erik J. Stemmy, Sally Hojvat, Michael Wathen, Timothy M. Uyeki
Publikováno v:
Emerging Infectious Diseases
Emerging Infectious Diseases, Vol 22, Iss 7, Pp-(2016)
Emerging Infectious Diseases, Vol 22, Iss 7, Pp-(2016)
Preclinical development of and research on potential Middle East respiratory syndrome coronavirus (MERS-CoV) medical countermeasures remain preliminary; advancements are needed before most countermeasures are ready to be tested in human clinical tria