Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Abba, J."'
Publikováno v:
Journal of Cellular Physiology. 228:1610-1616
Hyperleptinemia is usually associated with obesity and leptin resistance. Endothelial cell leptin receptor knockout (ELKO) mice without a signaling membrane-bound leptin receptor in endothelia, however, have profound hyperleptinemia without signs of
Publikováno v:
Journal of Cellular Physiology. 213:161-166
To examine how the proinflammatory cytokine tumor necrosis factor α (TNF) modulates the response of cerebral microvessels to other cytokines, we used rat cerebral microvessel endothelial RBE4 cells to simulate the in vitro blood-brain barrier (BBB).
Publikováno v:
Journal of Cellular Physiology. 214:301-305
Evidence both from mice and cultured cells suggests an important role of soluble leptin receptors in obesity and leptin signaling. However, the direct effects of soluble receptors on leptin uptake by cells are not clear. This study shows that soluble
Publikováno v:
Pharmacology Biochemistry and Behavior. 68:379-387
Methionine enkephalin (Met-enkephalin) functions as an endogenous anticonvulsant. Peptide transport system-1 (PTS-1) is an important regulator of Met-enkephalin levels in brain and transports the peptide from brain to blood. In outbred mice, alcohol
Publikováno v:
Pharmacology Biochemistry and Behavior. 40:771-774
The ability of naltrexone but not methyl naltrexone to cross the blood-brain barrier (BBB) was used to provide a different approach for the demonstration that opiates can enter the brain. Cortical electroencephalographic (EEG) measurements were made
Publikováno v:
Journal of cellular physiology. 212(1)
The cellular effects of leptin are dependent on the receptor subtypes that mediate the signaling and fate of endocytosed leptin inside the cells. In this study, we examined the differences in receptor expression, endocytosis, intracellular degradatio
Publikováno v:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 33(1)
Adrenomedullin (ADM) is present both in the periphery and brain. In addition to its peripheral effects, this peptide can exert central effects such as decreasing food ingestion. We used multiple-time regression analysis to determine that labeled ADM
Autor:
Weihong Pan, Abba J. Kastin
Publikováno v:
Regulatory peptides. 92(1-3)
Regulation of the transport of leptin across the blood-brain barrier (BBB) may be crucial for its effects on food ingestion and obesity and may be responsible for 'leptin resistance'. This review summarizes current studies of leptin indicating a dyna
Publikováno v:
Regulatory peptides. 91(1-3)
Pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to be a potent neuroprotective agent in global and focal ischemia. We demonstrated that PACAP could cross the blood-brain barrier (BBB) by a saturable transport system, and a s
Publikováno v:
Pharmacology, biochemistry, and behavior. 51(1)
Blood-borne pancreatic polypeptide (PP) affects pancreatic secretion indirectly by acting through the central nervous system (CNS). PP, which is apparently not synthesized by brain, must cross the blood-brain barrier (BBB) to reach areas such as the