Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Jason Carnes, Suzanne M. McDermott, Kenneth Stuart, Ira J. Blader, Juan Alfonzo, Jorge Cruz-Reyes
Publikováno v:
mSphere, Vol 3, Iss 1 (2018)
mSphere, Vol 3, Iss 1, p e00585-17 (2018)
mSphere, Vol 3, Iss 1, p e00585-17 (2018)
Editosomes are the multiprotein complexes that catalyze the insertion and deletion of uridines to create translatable mRNAs in the mitochondria of kinetoplastids. Recognition and cleavage of a broad diversity of RNA substrates in vivo require three f
Publikováno v:
Molecular and Cellular Biology. 22:4652-4660
Trypanosome RNA editing is a unique U insertion and U deletion process that involves cycles of pre-mRNA cleavage, terminal U addition or U removal, and religation. This editing can occur at massive levels and is directed by base pairing of trans-acti
Autor:
Alfredo J. Hernandez, Kenneth Stuart, Catherine Cifuentes-Rojas, Aswini K. Panigrahi, Jorge Cruz-Reyes, Anastasia Sacharidou
Publikováno v:
Journal of molecular biology. 381(1)
U-insertion/deletion RNA editing in the single mitochondrion of kinetoplastids, an ancient lineage of eukaryotes, is a unique mRNA maturation process needed for translation. Multisubunit editing complexes recognize many pre-edited mRNA sites and modi
Autor:
Alfredo J. Hernandez, Paula Pavia, Daniel Osterwisch, Jorge Cruz-Reyes, Catherine Cifuentes-Rojas, Concepción J. Puerta
Publikováno v:
The Journal of biological chemistry. 282(7)
Multisubunit RNA editing complexes catalyze uridylate insertion/deletion RNA editing directed by complementary guide RNAs (gRNAs). Editing in trypanosome mitochondria is transcript-specific and developmentally controlled, but the molecular mechanisms
Autor:
Kari Halbig, Anastasia Sacharidou, Mónica De Nova-Ocampo, Catherine Cifuentes-Rojas, Jorge Cruz-Reyes
Publikováno v:
Nucleic Acids Research
Trypanosome RNA editing by uridylate insertion or deletion cycles is a mitochondrial mRNA maturation process catalyzed by multisubunit complexes. A full-round of editing entails three consecutive steps directed by partially complementary guide RNAs:
Publisher Summary Electrophoretic migration of RNA is affected by its terminal OH or P character to a sizable and variable extent, considerably more than is DNA. If not accounted for when sizing RNA, errors of up to two nucleotides can arise, even wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8009f6ce1349361f24b2240f9e56a39d
https://doi.org/10.1016/s0076-6879(01)42560-2
https://doi.org/10.1016/s0076-6879(01)42560-2
Publikováno v:
Molecular cell. 1(3)
In the currently envisioned mechanism of trypanosome mitochondrial RNA editing, U-insertion and U-deletion cycles begin with a common kind of gRNA-directed cleavage. However, natural, altered, and mutationally interconverted editing sites reveal that