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pro vyhledávání: '"Carmen Garnacho"'
A Comparative Study on the Alterations of Endocytic Pathways in Multiple Lysosomal Storage Disorders
Publikováno v:
Molecular Pharmaceutics. 13:357-368
Many cellular activities and pharmaceutical interventions involve endocytosis and delivery to lysosomes for processing. Hence, lysosomal processing defects can cause cell and tissue damage, as in lysosomal storage diseases (LSDs) characterized by lys
Publikováno v:
Molecular Pharmaceutics
Drugs often use endocytosis to achieve intracellular delivery, either by passive uptake from the extracellular fluid or by active targeting of cell surface features such as endocytic receptors. An example is enzyme replacement therapy, a clinically p
Autor:
Carmen Garnacho, John Leferovich, Edward H. Schuchman, Christine Gajewski, Julie A. Champion, Vladimir R. Muzykantov, Samir Mitragotri, Silvia Muro
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 16(8)
Endocytosis in endothelial cells (ECs) is important for many biomedical applications, including drug delivery by nano- and microscale carriers. However, little is known about how carrier geometry influences endothelial drug targeting, intracellular t