Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael J. Kruhlak"'
Autor:
Gianluca Pegoraro, Nicholas Zolnerowich, Sergio Ruiz, Catherine N. Domingo, Maria Vega-Sendino, André Nussenzweig, Mariajose Franco, Elphège P. Nora, Peter C. FitzGerald, Desiree Tillo, Michael J. Kruhlak, Marta Markiewicz-Potoczny, Teresa Olbrich, Raphael Souza Pavani, Wei Wu, Eros Lazzerini-Denchi, Andy Tran
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Totipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from E
Autor:
Catherine N. Domingo, Gianluca Pegoraro, Michael J. Kruhlak, Peter C. FitzGerald, Elphège P. Nora, Mariajose Franco, Nicholas Zolnerowich, Lazzerini-Denchi E, Marta Markiewicz-Potoczny, André Nussenzweig, Desiree Tillo, Teresa Olbrich, Ruiz S, Maria Vega-Sendino, Wei Wu, Andy Tran
SUMMARYTotipotent cells have the ability of generating embryonic and extra-embryonic tissues1,2. Interestingly, a rare population of cells with totipotent-like potential was identified within ESC cultures3. These cells, known as 2 cell (2C)-like cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c871ece94248233768462cf8645fbab
https://doi.org/10.1101/2020.12.20.423692
https://doi.org/10.1101/2020.12.20.423692
Autor:
Ping Wang, Yijun Ruan, Michael J. Kruhlak, Debasish Paul, Ruhul Amin, Maxwell P. Lee, Anjali Shukla, Gordon L. Hager, Jennifer E. Dwyer, Steven D. Cappell, Kent W. Hunter, Jacqueline Jufen Zhu, Simon Zhongyuan Tian, Sandra Burkett, R. Mark Simpson, Sohyoung Kim, Huaitian Liu, Andy Tran
Mechanical signals from the extracellular microenvironment have been implicated in tumor and metastatic progression. Here, we identified nucleoporin NUP210 as a metastasis susceptibility gene for human estrogen receptor positive (ER+) breast cancer a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7623d879d2dd7d704514853a4d490faf
https://doi.org/10.1101/2020.02.05.936518
https://doi.org/10.1101/2020.02.05.936518
Autor:
Gareth N. Corry, Juan Ausió, Darin McDonald, Hilmar Strickfaden, John Th'ng, Michèle Rouleau, Guy G. Poirier, Toyotaka Ishibashi, Jean-François Haince, Michael J. Kruhlak, D. Alan Underhill, Michael J. Hendzel
Publikováno v:
Journal of Biological Chemistry. 291:1789-1802
Chromatin undergoes a rapid ATP-dependent, ATM and H2AX-independent decondensation when DNA damage is introduced by laser microirradiation. Although the detailed mechanism of this decondensation remains to be determined, the kinetics of decondensatio
Autor:
Golnaz Vahedi, Maxwell R. Mumbach, Shawn C. Little, Naomi Goldman, Yeqiao Zhou, Jon C. Aster, Stephen C. Blacklow, Zachary Zapataro, Warren S. Pear, Jelena Petrovic, Kelly S. Rome, Gregory W. Schwartz, Yogev Sela, Maria Fasolino, Michael J. Kruhlak, Eric F. Joyce, Son C. Nguyen, Junwei Shi, Robert B. Faryabi
Publikováno v:
Molecular cell. 73(6)
Chromatin loops enable transcription factor-bound distal enhancers to interact with their target promoters to regulate transcriptional programs. Although developmental transcription factors, such as active forms of Notch, can directly stimulate trans
Publikováno v:
The Journal of Cell Biology
Double-strand break (DSB) damage in yeast and mammalian cells induces the rapid ATM (ataxia telangiectasia mutated)/ATR (ataxia telangiectasia and Rad3 related)-dependent phosphorylation of histone H2AX (gamma-H2AX). In budding yeast, a single endonu
Autor:
Oscar Fernandez-Capetillo, David W. Staudt, André Nussenzweig, Alicia Lee, Arkady Celeste, Michael J. Kruhlak, Robert F. Bonner, Duane R. Pilch, William M. Bonner
Publikováno v:
Nature Cell Biology. 5:675-679
Histone H2AX is rapidly phosphorylated in the chromatin micro-environment surrounding a DNA double-strand break (DSB). Although H2AX deficiency is not detrimental to life, H2AX is required for the accumulation of numerous essential proteins into irra
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1703-1717 (2014)
Summary: The DNA damage response (DDR) occurs in the context of chromatin, and architectural features of chromatin have been implicated in DNA damage signaling and repair. Whereas a role of chromatin decondensation in the DDR is well established, we
Autor:
David P. Bazett-Jones, Michael J. Hendzel, Melody A Lever, Natalie A.B MacLean, Michael J. Kruhlak, F.-Michel Boisvert
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 76:9-21
The cell nucleus is increasingly recognized as a spatially organized structure. In this review, the nature and controversies associated with nuclear compartmentalization are discussed. The relationship between nuclear structure and organization of pr
Autor:
Charlotte A. Spencer, Michael J. Kruhlak, Xuejun Sun, Heather L. Jenkins, David P. Bazett-Jones
Publikováno v:
The Journal of Cell Biology
All nuclear RNA synthesis is repressed during the mitotic phase of the cell cycle. In addition, RNA polymerase II (RNAP II), nascent RNA and many transcription factors disengage from DNA during mitosis. It has been proposed that mitotic transcription