Zobrazeno 1 - 10
of 10
pro vyhledávání: '"David Dilworth"'
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Autor:
Neda Savic, Joseph M Dobbs, Misha Bilenky, David Dilworth, Christopher J. Nelson, Martin Hirst, Shawn P. Shortill
Publikováno v:
Genetics
Gene duplications increase organismal robustness by providing freedom for gene divergence or by increasing gene dosage. The yeast histone chaperones Fpr3 and Fpr4 are paralogs that can assemble nucleosomes in vitro; however, the genomic locations the
Autor:
Jinrong Min, Matthew R. Marunde, Dmitri Kireev, Jack Greenblatt, Ferreira de Freitas R, Tigran M. Abramyan, Cheryl H. Arrowsmith, Peter Brown, Magda Szewczyk, Irene Chau, A. Dong, Kazemzadeh S, Dalia Barsyte-Lovejoy, Ronan P Hanley, Mengqi Zhou, Y. Liu, Michael-Christopher Keogh, Lindsey I. James, Edyta Marcon, Matthieu Schapira, David Dilworth, Ming Lei, Popova Ik, Albina Bolotokova, Marcus A. Cheek, Masoud Vedadi, Elisa Gibson, Suzanne Ackloo, Su Qin, Matthew J. Meiners, Nathan W. Hall, Abdellah Allali-Hassani, Naimee Mehta, Fengling Li
NSD2 is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36me2), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methyltransferase domain, NSD2 harbors two PWWP and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4c6ef23b32f1b09d83b9d0588c0ec9
https://doi.org/10.1101/2021.03.05.433782
https://doi.org/10.1101/2021.03.05.433782
Autor:
Shadan H Abdali, Lifeng Liu, Robert B. Hutmacher, Kim K. Hixson, Tanya E. Winkler, Benjamin J. Cole, Christer Jansson, Julie A. Sievert, Ljiljana Paša-Tolić, Amir H. Ahkami, Mary Madera, Neha Malhan, Mowei Zhou, Joy Hollingsworth, Peggy G. Lemaux, Jeff Dahlberg, Judith A Owiti, David Dilworth
Histones belong to a family of highly conserved proteins in eukaryotes. They pack DNA into nucleosomes as functional units of chromatin. Post-translational modifications (PTMs) of histones, which are highly dynamic and can be added or removed by enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e5e6370dd82f69523d27f2c9d907d6
https://escholarship.org/uc/item/9h02d61k
https://escholarship.org/uc/item/9h02d61k
Autor:
Xiao-Ling Cockcroft, Stephan Karl Zahn, Mark Petronczki, Catherine M. Rogers, Fengling Li, Helmut Berger, Bernadette Sharps, Markus Zeeb, Ralph A. Neumüller, Mark Pearson, Dalia Barsyte-Lovejoy, Teresa Krammer, Oleg Fedorov, Barbara Müllauer, Alexander Weiss-Puxbaum, Kilian Huber, Masoud Vedadi, Magdalena M. Szewczyk, Christopher R. Vakoc, Abdellah Allali-Hassani, Tobias Wunberg, Steven Kennedy, Christoph Reiser, Michael Schleicher, Julian E. Fuchs, Cheryl H. Arrowsmith, Moriz Mayer, Jark Böttcher, Guido Boehmelt, Dietrich Böse, Alexandra Hörmann, Andreas Zoephel, Heribert Arnhof, Sandra Winkler, Darryl B. McConnell, Peter Brown, David Dilworth, Maja Corcokovic, Klaus Rumpel, Thomas Gerstberger, Nikolai Mischerikow, Carrow I. Wells, Ulrich Reiser, Daniela Häring
Publikováno v:
Nature Chemical Biology. 15:822-829
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is encoded by the WHSC1L1 gene located in the 8p11-p12 amplicon, frequently amplified in brea
Autor:
Dalia Barsyte-Lovejoy, David Dilworth
Publikováno v:
Cellular and molecular life sciences : CMLS. 76(15)
The methylation of proteins is integral to the execution of many important biological functions, including cell signalling and transcriptional regulation. Protein methyltransferases (PMTs) are a large class of enzymes that carry out the addition of m
Autor:
Neda Savic, Shawn P. Shortill, Misha Bilenky, David Dilworth, Christopher J. Nelson, Martin Hirst
Gene duplications increase organismal robustness by providing freedom for gene divergence or by increasing gene dosage. The yeast histone chaperones Fpr3 and Fpr4 are paralogs that can assemble nucleosomesin vitro, however the genomic locations they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c8b6e2f1e5342e72b929ea98364c03
Autor:
Leigh Anne Swayne, Misha Bilenky, Connor O'Sullivan, Evgeniy V Petrochenko, Perry L. Howard, David Dilworth, Xiaoxue Xu, Geoff Gudavicius, Christoph H. Borchers, Martin Hirst, Christopher J. Nelson, Andrew K. J. Boyce, Jason J. Serpa
Publikováno v:
Nucleic Acids Research
FK506 binding proteins (FKBPs) catalyze the interconversion of cis-trans proline conformers in proteins. Importantly, FK506 drugs have anti-cancer and neuroprotective properties, but the effectors and mechanisms underpinning these properties are not
Publikováno v:
Biochemistry and Cell Biology. 90:55-69
The post-translational modification of proteins and enzymes provides a dynamic and reversible means to control protein function and transmit biological signals. While covalent modifications such as phosphorylation and acetylation have drawn much atte
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 90(1)
The post-translational modification of proteins and enzymes provides a dynamic and reversible means to control protein function and transmit biological signals. While covalent modifications such as phosphorylation and acetylation have drawn much atte