Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mats Gåfvels"'
Autor:
Mats Gåfvels, Gösta Eggertsen, Olga Ovchinnikova, Paolo Parini, Katharina Slätis, Kristina Kannisto, Gabrielle Paulsson-Berne, Zhao-Yan Jiang
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3289-3298 (2010)
To investigate the effects of abolished cholic acid (CA) synthesis in the ApoE knockout model [apolipoprotein E (apoE) KO],a double-knockout (DKO) mouse model was created by crossbreeding Cyp8b1 knockout mice (Cyp8b1 KO), unable to synthesize the pri
Autor:
Ingemar Björkhem, Curt Einarsson, Maria Olin, Gösta Eggertsen, Jin Wang, Mats Gåfvels, Björn Rozell
Publikováno v:
Histochemistry and Cell Biology. 127:253-261
The synthesis of primary bile acids is confined to the hepatocytes. This study aimed to evaluate the expression pattern within the liver architecture of the rate-limiting enzyme of the neutral pathway, cholesterol 7alpha-hydroxylase (Cyp7a1), and ste
Autor:
Paolo Parini, Charlotte Murphy, Ingemar Björkhem, Mats Gåfvels, Jin Wang, Curt Einarsson, Gösta Eggertsen
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 2, Pp 421-430 (2006)
As previously reported by us, mice with targeted disruption of the CYP8B1 gene (CYP8B1-/-) fail to produce cholic acid (CA), upregulate their bile acid synthesis, reduce the absorption of dietary cholesterol and, after cholesterol feeding, accumulate
Publikováno v:
Scandinavian Journal of Clinical and Laboratory Investigation. 65:595-600
In humans, two primary bile acids are synthesized: cholic acid (CA) and chenodeoxycholic acid (CDCA), the first and rate-limiting enzyme being cholesterol 7alpha-hydroxylase (CYP7A1). CA has one more hydroxyl group at position 12alpha. This hydroxyla
Autor:
Mats Gåfvels, Yi-Zeng Yang, Ingemar Björkhem, Curt Einarsson, Ulla Andersson, Gösta Eggertsen, John Y.L. Chiang
Publikováno v:
Biochemical and Biophysical Research Communications. 320:1204-1210
Sterol 12α-hydroxylase (CYP8B1) is an obligatory enzyme for the synthesis of cholic acid and regulation of liver bile acid synthesis and intestine cholesterol absorption. The present study evaluates the roles for sterol regulatory element binding pr
Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice
Autor:
Mats Rudling, Curt Einarsson, Charlotte Murphy, Jin Wang, Mats Gåfvels, Ingemar Björkhem, Gösta Eggertsen
Publikováno v:
Biochemical and biophysical research communications. 342(4)
We studied bile acid and cholesterol metabolism in insulin-dependent diabetes utilizing genetically modified mice unable to synthesize cholic acid (Cyp8b1−/−). Diabetes was induced in Cyp8b1−/− and wild type animals (Cyp8b1+/+) by alloxan, an
Publikováno v:
Biochimica et biophysica acta. 1735(3)
To study the effects of cholic acid (CA) feeding on hepatic cholesterol metabolism, male sterol 12alpha-hydroxylase (CYP8B1) knockout (-/-) mice and wildtype controls (+/+) were fed either a control diet or the same diet supplemented with CA (0.1% or
Autor:
Jia Li-Hawkins, Mats Gåfvels, Maria Olin, Erik G. Lund, Ulla Andersson, Gertrud Schuster, Ingemar Björkhem, David W. Russell, Gosta Eggertsen
Publikováno v:
The Journal of clinical investigation. 110(8)
Cholesterol is converted into dozens of primary and secondary bile acids through pathways subject to negative feedback regulation mediated by the nuclear receptor farnesoid X receptor (FXR) and other effectors. Disruption of the sterol 12alpha-hydrox
Autor:
Yi-Zeng Yang, Claes M. Carneheim, Stefan E.H. Alexson, Mary C. Hunt, Mats Gåfvels, Curt Einarsson, Gösta Eggertsen
Publikováno v:
The Journal of biological chemistry. 275(37)
Fibrates are a group of hypolipidemic agents that efficiently lower serum triglyceride levels by affecting the expression of many genes involved in lipid metabolism. These effects are exerted via the peroxisome proliferator-activated receptor alpha (