Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Wei-Yi Ong"'
Autor:
Wei-Yi Ong, Samantha Chia Yi Ooi, Sally Shuxian Koh, Cao Qiong, Leona Ting Yuke Ho, Irwin K. Cheah, Barry Halliwell, Natalie Man Yin Lui, Deron R. Herr
Publikováno v:
NeuroMolecular Medicine
Neuromolecular Medicine
Neuromolecular Medicine
Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current s
Publikováno v:
Neuroscience Bulletin. 26:197-204
Cholesterol 24-hydroxylase catalyzes the conversion of cholesterol to 24-hydroxycholesterol, which is a major pathway for cholesterol elimination from the brain, since 24-hydroxycholesterol can readily cross the blood brain barrier. The present study
Publikováno v:
Journal of Neural Transmission. 117:301-308
Secretory phospholipase A2 (sPLA2) activity is present in the CNS and the sPLA2-IIA isoform has been shown to induce exocytosis in cultured hippocampal neurons. However, little is known about possible contributions of various lysophospholipid species
Publikováno v:
Biophysical Journal. 97:1371-1380
Although it is well established that exocytosis of neurotransmitters and hormones is highly regulated by numerous secretory proteins, such as SNARE proteins, there is an increasing appreciation of the importance of the chemophysical properties and or
Publikováno v:
Brain Research Reviews. 56:443-471
Neural membranes are composed of glycerophospholipids, sphingolipids, cholesterol and proteins. The distribution of these lipids within the neural membrane is not random but organized. Neural membranes contain lipid rafts or microdomains that are enr
Autor:
Barry Halliwell, Ning Pan, Andrew M. Jenner, Wei-Yi Ong, Benny K. H. Tan, Frank Watt, Choon Nam Ong, Matthew Whiteman
Publikováno v:
Mechanisms of Ageing and Development. 125:305-313
The link between hypercholesterolemia and neuronal damage is not clear. In the present study, we studied some of the possible effects of hypercholesterolemia on the brain, using the cholesterol fed New Zealand White rabbit as a model. An increase in
Autor:
Wei-Yi Ong, Barry Halliwell
Publikováno v:
Annals of the New York Academy of Sciences. 1012:51-64
This article reviews the roles and interactions of iron, atherosclerosis, and neurodegeneration. It highlights the importance of cholesterol in promoting iron-dependent oxidative damage. An intriguing possibility is that hypercholesterolemia can incr
Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice
Autor:
Gunter P. Eckert, W. Gibson Wood, Urule Igbavboa, Gero P. Hooff, Wei-Yi Ong, Walter E. Müller, Ji-Hyun Kim
Publikováno v:
Molecular neurobiology. 46(1)
The mevalonate/isoprenoids/cholesterol pathway has a fundamental role in the brain. Increasing age could be associated with specific changes in mevalonate downstream products. Other than age differences in brain cholesterol and dolichol levels, there
Autor:
J. Jittiwat, Akhlaq A. Farooqui, Eng Shi Ong, Wei-Yi Ong, Andrew M. Jenner, S.-M. Ee, Ji-Hyun Kim
Publikováno v:
Neuroscience. 185
Significant increases in levels of cholesterol and cholesterol oxidation products are detected in the hippocampus undergoing degeneration after excitotoxicity induced by the potent glutamate analog, kainate (KA), but until now, it is unclear whether
Publikováno v:
Molecular neurobiology. 41(2-3)
Excitotoxicity due to excess stimulation of glutamate receptors in neurons is accompanied by increased Ca(2+) influx, stimulation of Ca(2+)-dependent enzymes, ATP depletion, increase in lipid peroxidation products, and loss of glutathione. These chan