Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mats Gåfvels"'
Autor:
Mats Gåfvels, Carl Jorns, Kristina Kannisto, X. Hu, Katharina Slätis, Zhao-Yan Jiang, Knut R. Steffensen, Gösta Eggertsen
Publikováno v:
Lipids. 49:71-83
We investigated whether: (1) liver X receptor (LXR)-driven induction of high-density lipoprotein cholesterol (HDL-C) and other LXR-mediated effects on cholesterol metabolism depend on intestinal cholesterol absorption; and (2) combined treatment with
Autor:
Paolo Parini, Jan-Åke Gustafsson, Mats Gåfvels, X. Hu, Knut R. Steffensen, Zhao-Yan Jiang, Gösta Eggertsen
Publikováno v:
Journal of Internal Medicine. 272:452-464
Hu X, Steffensen KR, Jiang Z-Y, Parini P, Gustafsson J-A, Gafvels M, Eggertsen G (Karolinska Institutet, Huddinge, Stockholm, Sweden; Karolinska Institutet, Huddinge, Stockholm, Sweden; Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shangh
Autor:
Mats Gåfvels, Gösta Eggertsen, Olga Ovchinnikova, Paolo Parini, Katharina Slätis, Kristina Kannisto, Gabrielle Paulsson-Berne, Zhao-Yan Jiang
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3289-3298 (2010)
To investigate the effects of abolished cholic acid (CA) synthesis in the ApoE knockout model [apolipoprotein E (apoE) KO],a double-knockout (DKO) mouse model was created by crossbreeding Cyp8b1 knockout mice (Cyp8b1 KO), unable to synthesize the pri
Autor:
Ingemar Björkhem, Curt Einarsson, Maria Olin, Gösta Eggertsen, Jin Wang, Mats Gåfvels, Björn Rozell
Publikováno v:
Histochemistry and Cell Biology. 127:253-261
The synthesis of primary bile acids is confined to the hepatocytes. This study aimed to evaluate the expression pattern within the liver architecture of the rate-limiting enzyme of the neutral pathway, cholesterol 7alpha-hydroxylase (Cyp7a1), and ste
Autor:
Paolo Parini, Charlotte Murphy, Ingemar Björkhem, Mats Gåfvels, Jin Wang, Curt Einarsson, Gösta Eggertsen
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 2, Pp 421-430 (2006)
As previously reported by us, mice with targeted disruption of the CYP8B1 gene (CYP8B1-/-) fail to produce cholic acid (CA), upregulate their bile acid synthesis, reduce the absorption of dietary cholesterol and, after cholesterol feeding, accumulate
Autor:
Per Bengtson, Mats Gåfvels
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry. 442
Background Surrogate markers for reverse cholesterol transport (RCT) efficiency such as HDL cholesterol and immune methods for apolipoprotein A-I (ApoA-I) may not fully reflect the actual efficiency of the RCT pathway. Several genetic variants and di
Publikováno v:
Scandinavian Journal of Clinical and Laboratory Investigation. 65:595-600
In humans, two primary bile acids are synthesized: cholic acid (CA) and chenodeoxycholic acid (CDCA), the first and rate-limiting enzyme being cholesterol 7alpha-hydroxylase (CYP7A1). CA has one more hydroxyl group at position 12alpha. This hydroxyla
Autor:
Mats Gåfvels, Yi-Zeng Yang, Ingemar Björkhem, Curt Einarsson, Ulla Andersson, Gösta Eggertsen, John Y.L. Chiang
Publikováno v:
Biochemical and Biophysical Research Communications. 320:1204-1210
Sterol 12α-hydroxylase (CYP8B1) is an obligatory enzyme for the synthesis of cholic acid and regulation of liver bile acid synthesis and intestine cholesterol absorption. The present study evaluates the roles for sterol regulatory element binding pr
Autor:
Lilian Larsson, Mats Gåfvels, Kristina Kannisto, Paolo Parini, Stefan Rehnmark, Gösta Eggertsen, Katharina Slätis, Paul Webb
Publikováno v:
Atherosclerosis. 237(2)
Thyroid hormone reduces plasma cholesterol and increases expression of low-density lipoprotein receptor (LDL-R) in liver, an effect mediated by thyroid receptor β (TRβ). The selective TRβ modulator GC-1 also enhances several steps in reverse chole
Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice
Autor:
Mats Rudling, Curt Einarsson, Charlotte Murphy, Jin Wang, Mats Gåfvels, Ingemar Björkhem, Gösta Eggertsen
Publikováno v:
Biochemical and biophysical research communications. 342(4)
We studied bile acid and cholesterol metabolism in insulin-dependent diabetes utilizing genetically modified mice unable to synthesize cholic acid (Cyp8b1−/−). Diabetes was induced in Cyp8b1−/− and wild type animals (Cyp8b1+/+) by alloxan, an