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pro vyhledávání: '"Qingzhen Yu"'
Autor:
Irina A. Pikuleva, Tuo Shao, Zhen Chen, Qingzhen Yu, Yihan Shao, Jiahui Chen, Xiaoyun Deng, Hualong Fu, Steven H. Liang, Jiyun Sun, Natalia Mast, Thomas Lee Collier, Lee Josephson, Jian Rong
Publikováno v:
Bioorg Med Chem Lett
Cholesterol 24-hydroxylase is a monooxygenase encoded by CYP46A1, which is specifically expressed in the brain where it controls cholesterol elimination by producing 24S-hydroxylcholesterol (24-HC) as the major metabolite. Selective blockade of CYP46