Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Stephen S Whitehead"'
Autor:
Guangping Liu, Natalia L Teterina, Emerito Amaro-Carambot, Craig Martens, Stephen S. Whitehead, Alexander G. Pletnev, Olga A. Maximova, Jeffrey M. Grabowski, Marshall E. Bloom, Heather Kenney, Luwanika Mlera, Elaine W. Lamirande, Konstantin A. Tsetsarkin, Bianca M. Nagata, Ian N. Moore
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract (MRT) poses new challenges for controlling virus outbreaks and developing live-attenuated vaccines. To elucidate routes of ZIKV dissemination in the MRT, we here
Autor:
Julie Callison, Dana P. Scott, Andrea Marzi, Nicolette Arndt, Stephen S. Whitehead, Kristin L. McNally, David Safronetz, Spencer Chadinha, Heinz Feldmann, Cynthia Martellaro, Jackson Emanuel, Rebecca Rosenke, Sonja M. Best
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
The common small animal disease models for Zika virus (ZIKV) are mice lacking the interferon responses, but infection of interferon receptor α/β knock out (IFNAR−/−) mice is not uniformly lethal particularly in older animals. Here we sought to
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 92:98-107
The live-attenuated Japanese encephalitis virus (JEV) SA14-14-2 vaccine, produced in primary hamster kidney cells, is safe and effective. Past attempts to adapt this virus to replicate in cells that are more favorable for vaccine production resulted
Autor:
Stephen S. Whitehead, Meredith Brown, Mathilde Guerbois, Nikos Vasilakis, Tiffany F. Kautz, Kathryn A. Hanley, Preston A. Marx, Scott C. Weaver
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 91:672-676
The four serotypes of mosquito-borne dengue virus (DENV-1, -2, -3, and -4) that circulate in humans each emerged from an enzootic, sylvatic cycle in non-human primates. Herein, we present the first study of sylvatic DENV infection dynamics in a prima
Autor:
Katherine I. Young, Stephen S. Whitehead, Ebenezer Tumban, Erin E. Schirtzinger, Kathryn A. Hanley, Nyree E. Maes, Christopher T. Hanson
Publikováno v:
Journal of General Virology. 94:783-788
The genus Flavivirus includes both vector-borne and no known vector (NKV) species, but the molecular determinants of transmission mode are not known. Conserved sequence differences between the two groups occur in 5′ and 3′ UTRs. To investigate th
Autor:
Chunling Wang, Philippe Buchy, Laura A. VanBlargan, Theodore C. Pierson, Robert V. Gibbons, Nikos Vasilakis, Gregory D. Gromowski, Louis Lau, Albert D. M. E. Osterhaus, John Aaskov, Angela M. Green, Sarah James, Eva Harris, Stephen S. Whitehead, Jorge L. Muñoz-Jordán, Leah C. Katzelnick, Colin A. Russell, Anna P. Durbin, Judith M. Fonville, Jose Bustos Arriaga, Magelda Montoya, Ron A. M. Fouchier, Hlaing Myat Thu, Cameron P. Simmons, Edward C. Holmes, Robert B. Tesh, Derek J. Smith
Publikováno v:
Science, 349(6254), 1338-1343. American Association for the Advancement of Science
The devil in the dengue details Along with their mosquito vectors, dengue viruses are spreading worldwide to infect millions of people. For a few, subsequent infection results in lethal hemorrhagic disease. Katzelnick et al. used antibody-binding dat
Publikováno v:
Journal of virology. 89(12)
The safety and efficacy of the live-attenuated Japanese encephalitis virus (JEV) SA14-14-2 vaccine are attributed to mutations that accumulated in the viral genome during its derivation. However, little is known about the contribution that is made by
Autor:
Brian R. Murphy, Cai Yen Firestone, Stephen S. Whitehead, Daniel H. Johnson, Joseph E. Blaney, Christopher T. Hanson, Gracielle G Manipon
Publikováno v:
Vaccine. 21:4317-4327
Mutations which increase the replication of dengue viruses in cell culture would greatly facilitate the manufacture of both a live attenuated or inactivated dengue virus vaccine. We have identified eight missense mutations in dengue virus type 4 (DEN
Autor:
Kathryn A. Hanley, Stephen S. Whitehead, Brian R. Murphy, Lara E Gilmore, William R. Elkins, Joseph E. Blaney
Publikováno v:
Vaccine. 21:4307-4316
Antigenic chimeric viruses in which the structural genes of dengue virus type 4 (DEN4) have been replaced with those derived from dengue virus type 2 (DEN2) have been created and evaluated as a first step in generating a live attenuated tetravalent d
Autor:
Stephen S. Whitehead, Swati Mukherjee, Anna P. Durbin, Theodore C. Pierson, Kimberly A. Dowd, Julie E. Ledgerwood, Carolyn J. Manhart
The production of neutralizing antibodies (NAbs) is a correlate of protection for many human vaccines, including currently licensed vaccines against flaviviruses. NAbs are typically measured using a plaque reduction neutralization test (PRNT). Despit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1975ebba87bf9d66b4f9d69936fb44f9
https://europepmc.org/articles/PMC4054442/
https://europepmc.org/articles/PMC4054442/