Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laura Lazo"'
Autor:
María G. Guzmán, Hoang Anh Duc, Edith Suzarte, Hoang Duc Loc, Alienys Izquierdo, Phuong Thao, Melyssa Yaugel, Laura Lazo, Ernesto Marcos, Lisset Hermida, Do Tuan Dat, Le Trung Dung, Yusleidi Pérez, Yaremis Romero, Karem Cobas, Lázaro Gil, Iris Valdés, Nguyen Dan Hien, Gerardo Guillén
Publikováno v:
Journal of General Virology. 100:975-984
The development of live-attenuated vaccines against Dengue virus (DENV) has been problematic. Dengvaxia, licensed in several countries where DENV is endemic, has shown low efficacy profiles and there are safety concerns prohibiting its administration
Autor:
Yadira Rodríguez, Enma Brown, Gerardo Guillén, Laura Lazo, Ernesto Marcos, Yusleidi Pérez, Iris Valdés, Melyssa Yaugel, Karem Cobas, Lisset Hermida, Edith Suzarte, Lázaro Gil
Publikováno v:
Archives of Virology. 162:2247-2256
Tetra DIIIC is a subunit vaccine candidate based on domain III of the envelope protein and the capsid protein of the four serotypes of dengue virus. This vaccine preparation contains the DIIIC proteins aggregated with a specific immunostimulatory oli
Autor:
Thomas Kariuki, Prisilla Kimiti, Lucy Ochola, Gerardo Guillén, Iris Valdés, María G. Guzmán, Lázaro Gil, Ernesto Marcos, James Ndung'u, Lisset Hermida, Peris Ambala, Mayling Alvarez, Alienys Izquierdo, Laura Lazo, Rikoi Hitler, Edith Suzarte
Publikováno v:
Immunology & Cell Biology. 93:57-66
Previously, we reported the ability of the chimeric protein DIIIC-2 (domain III of the dengue envelope protein fused to the capsid protein of dengue-2 virus), to induce immunity and protection in mice, when it is highly aggregated with a non-defined
Autor:
Iris Valdés, Lázaro Gil, Thomas Kariuki, Edith Suzarte, Laura Lazo, Ernesto Marcos, Alienys Izquierdo, Guadalupe Guzmán, Peris Ambala, Gerardo Guillén, Lucy Ochola, Lisset Hermida
Publikováno v:
Virology. :70-76
The role of cellular immune response in dengue virus infection is not yet fully understood. Only few studies in murine models propose that CD8+ T-cells are associated with protection from infection and disease. At the light of recent reports about th
Autor:
Edith Suzarte, María G. Guzmán, Ernesto Marcos, Yusleydis Pérez, Lázaro Gil, Gerardo Guillén, Alienys Izquierdo, Laura Lazo, Aracelys Blanco, Yaremis Romero, José Suárez Alba, Iris Valdés, Lisset Hermida, Julio Ancizar, Karen Cobas
Publikováno v:
Immunology letters. 176
Despite the many efforts made by the scientific community in the development of vaccine candidates against dengue virus (DENV), no vaccine has been licensed up to date. Although the immunopathogenesis associated to the disease is a key factor to take
Autor:
Carlos López, Jorge Martín, Jorge Fernandez de Castro, Laura Lazo, María G. Guzmán, Lázaro Gil, Gerardo Guillén, Jorge Sánchez, Yaremis Romero, Lidice Bernardo, Olivia Niebla, Iris Valdés, Tamara Menéndez, Lisset Hermida
Publikováno v:
International Journal of Infectious Diseases. 14(5):e377-e383
Objective The aim of the present work was to test the concept of the heterologous prime-boost strategy combining an infective dengue virus with a recombinant chimeric protein carrying domain III of the envelope protein. Methods Two studies in monkeys
Autor:
Jorge Sánchez, Rafael Martínez, María G. Guzmán, Gerardo Guillén, Tamara Menéndez, Lázaro Gil, Jorge Martín, Laura Lazo, Yaremis Romero, Olivia Niebla, Iris Valdés, Lisset Hermida, Lidice Bernardo, Jorge Fernandez de Castro, Carlos López
Publikováno v:
Vaccine. 27:995-1001
The main problem in the development of successful vaccines against dengue based on recombinant proteins is the necessity to use potent adjuvants to reach a proper functional immune response. Our group reported the expression, characterization and imm
Autor:
Gerardo Guillén, Lázaro López, Laura Lazo, Yusleydis Pérez, Alienys Izquierdo, Ernesto Marcos, Jorge Fernandez de Castro, María G. Guzmán, Maylin Álvarez, Lázaro Gil, Iris Valdés, Lisset Hermida, Edith Suzarte, Angélica García, Yaremis Romero
Publikováno v:
International immunology. 27(8)
Our group developed a subunit vaccine candidate against dengue virus based on two different viral regions: the domain III of the envelope protein and the capsid protein. The novel chimeric protein from dengue-2 virus [domain III-capsid (DIIIC-2)], wh
Autor:
Ernesto Marcos, María G. Guzmán, Lázaro Gil, Laura Lazo, Gerardo Guillén, Yaremis Romero, Iris Valdés, Lisset Hermida, Jorge Fernandez de Castro, Pedro Puente
Publikováno v:
Clinical and vaccine immunology : CVI. 18(3)
Use of a heterologous prime-boost strategy based on a combination of nonreplicative immunogens and candidate attenuated virus vaccines against dengue virus in the same schedule is an attractive approach. These combinations may result in a condensed i
Autor:
Jorge, Martín, Lisset, Hermida, Jorge, Castro, Laura, Lazo, Rafael, Martínez, Lázaro, Gil, Yaremis, Romero, Pedro, Puente, Santiago, Zaragoza, Karelia, Cosme, Maria G, Guzmán, Jane, Cardosa, Gerardo, Guillén
Publikováno v:
Microbiology and immunology. 53(4)
The increasingly limited availability and high cost of the hitherto most commonly used monkey species in dengue vaccine research has augmented the importance of identifying alternative suitable models for these studies. In this study we examined the