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pro vyhledávání: '"Stefan McDonough"'
Publikováno v:
Biophysical Journal. 79(1):298-313
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel with distinctive kinetics. At the whole-cell level, CFTR currents in response to voltage steps are time independent for wild type and for the many mutants reported s
Autor:
Nael A. McCarty, Stefan McDonough, Bruce N. Cohen, Norman Davidson, John R Riordan, Henry A. Lester
Publikováno v:
The Journal of General Physiology
The gene defective in cystic fibrosis encodes a Cl- channel, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is blocked by diphenylamine-2-carboxylate (DPC) when applied extracellularly at millimolar concentrations. We studied th