Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Alexei A. Grom"'
Autor:
Virginia Miraldi Utz, Sheila T. Angeles-Han, Najima Mwase, Amy Cassedy, Theresa Hennard, Daniel J. Lovell, Sarah Lopper, Hermine I. Brunner, Eniolami O. Dosunmu, Alexei A. Grom, Michael Henrickson, Jennifer L. Huggins, Robert A. Sisk, Tracy V. Ting, Adam H. Kaufman
Publikováno v:
American journal of ophthalmology. 244
A significant number of children with noninfectious, chronic anterior uveitis (CAU) fail to respond to conventional therapy; however, successful alternative biologic treatments (ABT) have not been well described. This study aims to review the clinica
Autor:
Grant S. Schulert, Mekibib Altaye, Jackeline Rodriguez-Smith, Alyssa Sproles, Virginia Miraldi Utz, Sheila T. Angeles-Han, Sherry Thornton, Alexei A. Grom, Adam Kauffman, Najima Mwase, Theresa Hennard, Gary N. Holland
Publikováno v:
Ocul Immunol Inflamm
PURPOSE: Biomarkers for juvenile idiopathic arthritis-associated uveitis (JIA-U) are needed. We aimed to measure inflammatory biomarkers in tears as a non-invasive method to identify biomarkers of uveitis activity. METHODS: Tears were collected from
Autor:
Jipan Xie, Nina Kim, Kathleen G Lomax, Peter Hur, Raju Gautam, Jordan Cammarota, Raluca Ionescu-Ittu, Navneet Sanghera, Ameur M. Manceur, Alexei A. Grom
Publikováno v:
Pediatric Rheumatology Online Journal
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-13 (2021)
Pediatric Rheumatology Online Journal, Vol 19, Iss 1, Pp 1-13 (2021)
Background Although canakinumab has demonstrated efficacy in multiple trials in patients with periodic fever syndromes (PFS), the evidence on initiation of canakinumab among PFS patients in real world setting is not well understood. We aimed to chara
Publikováno v:
Arthritis Rheumatol
OBJECTIVE Canakinumab is a human anti-interleukin-1β (anti-IL-1β) blocking agent that effectively neutralizes IL-1β-mediated signaling for treatment of systemic juvenile idiopathic arthritis (JIA). While many patients have dramatic clinical respon
Autor:
Ndate Fall, Grant S. Schulert, Thuy Do, Sherry Thornton, Alex V. Pickering, Alexei A. Grom, Daniel Schnell, Mario Medvedovic, Nathan Salomonis, Sanjeev Dhakal
Publikováno v:
Annals of the rheumatic diseases. 80(5)
ObjectivesSystemic juvenile idiopathic arthritis (SJIA) confers high risk for macrophage activation syndrome (MAS), a life-threatening cytokine storm driven by interferon (IFN)-γ. SJIA monocytes display IFN-γ hyper-responsiveness, but the molecular
Autor:
Scott W. Canna, Joseph Han, Roberto Caricchio, Shawn A. Mahmud, Fabrizio De Benedetti, Pui Y. Lee, Kate F. Kernan, Lauren A. Henderson, Stefano Volpi, Angelo Ravelli, Melissa M. Hazen, Grant S. Schulert, Marco Gattorno, Randy Q. Cron, Edward M. Behrens, Olha Halyabar, Peter A. Nigrovic, Kacie J Hoyt, Alexei A. Grom
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Arthritis & Rheumatology
Arthritis & Rheumatology
Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418c0455db106b78ddf9c82c8887a7df
http://hdl.handle.net/11567/1023215
http://hdl.handle.net/11567/1023215
Autor:
Joshua E. Elias, Claudia Macaubas, Peggie Cheung, Peter A. Nigrovic, Alexei A. Grom, Paul J. Utz, Or Gozani, Tie-Mei Li, Purvesh Khatri, Lauren A. Henderson, Michele Donato, Elizabeth D. Mellins, John P. Coan, Grant S. Schulert, Lichao Zhang, Sarah E. Chang, Steven Schaffert, Mai Dvorak, Mariko Hinton Foecke, Alex J. Kuo
Publikováno v:
Nature immunology. 22(6)
Chromatin undergoes extensive reprogramming during immune cell differentiation. Here we report the repression of controlled histone H3 amino terminus proteolytic cleavage (H3ΔN) during monocyte-to-macrophage development. This abundant histone mark i
Autor:
Jon L. Woltmann, Robert W. Frenck, Grant S. Schulert, Andrew H. Shapiro, Alexei A. Grom, Onengiya Harry, Judith A. Smith
Publikováno v:
JCR: Journal of Clinical Rheumatology. 24:287-290
Autor:
Alexei A. Grom, Rachel Tan, Nan Shen, Thuy Do, Grant S. Schulert, Mark Bennett, Mario Medvedovic, Sherry Thornton
Publikováno v:
J Leukoc Biol
Systemic juvenile idiopathic arthritis (SJIA) is a severe childhood arthropathy with features of autoinflammation. Monocytes and macrophages in SJIA have a complex phenotype with both pro- and anti-inflammatory properties that combine features of sev
Autor:
Ndate Fall, Hermine I. Brunner, Jessica L Turnier, Simone Appenzeller, Sherry Thornton, Marisa S. Klein-Gitelman, David P. Witte, Michael R. Bennett, Alexei A. Grom
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-11 (2017)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins (S100A4, S100A6, S100A8/9, and S100A12) in both serum and urine as potential bioma