Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Heewon Lee"'
Autor:
Xiao-Jun Wang, Lifen Wu, Guisheng Li, Scott Pennino, Bo Qu, Heewon Lee, Xiaowen Hou, Anjan Saha, Jinhua J. Song, Xingzhong Zeng, Chris H. Senanayake, Nizar Haddad, Jon C. Lorenz
Publikováno v:
Organic Process Research & Development. 25:583-590
The development of multikilogram scale green and economical synthetic route of enantiomerically pure cis-4-amino-3-fluoro-1-methylpiperidine 1 is described. The synthesis features a highly regio-, ...
Autor:
Sergei Tcyrulnikov, Joshua D. Sieber, Nitinchandra D. Patel, Kendricks S. Lao, Marisa C. Kozlowski, Soumik Biswas, Chris H. Senanayake, Nelu Grinberg, Krishnaja Duvvuri, Neil K. Garg, B. Frank Gupton, Daniel Rivalti, Jinhua J. Song, Scott Pennino, Bo Qu, Heewon Lee, Donghong A. Gao, Yongda Zhang, Hari P. R. Mangunuru, Nizar Haddad, Bryan J. Simmons, Keith R. Fandrick
Publikováno v:
ACS Catalysis. 8:10190-10209
Metal-catalyzed cross-coupling reactions are extensively employed in both academia and industry for the synthesis of biaryl derivatives for applications to both medicine and material science. Application of these methods to prepare tetra-ortho-substi
Autor:
Amy R. Howell, Yibo Xu, Heewon Lee, Nizar Haddad, Yongda Zhang, Zhengxu S. Han, Jean-Nicolas Desrosiers, Jinhua J. Song, Nathan K. Yee, Linglin Wu, Xiao-Jun Wang, Kendricks S. Lao, Chris H. Senanayake, Joshua D. Sieber
Publikováno v:
Synthesis. 50:4429-4434
A new family of dihydrobenzoazaphosphosphole ligands was prepared and shown to enable modification of the phosphine electronic character by variation of the N-substituent. This new family of phosphines was shown to be highly active in the Pd-catalyze
Autor:
Zhengxu S. Han, Heewon Lee, Yongda Zhang, Chris H. Senanayake, Hao Wu, Frank Roschangar, Nelu Grinberg, Bo Qu, Dan Wang, Guijun Wang, Jinhua J. Song, Yibo Xu
Publikováno v:
Advanced Synthesis & Catalysis. 359:3927-3933
P-Stereogenic chiral phosphine BI-BOP is employed for the first time as ligand to promote catalytic enantioselective synthesis of phosphoryl-substituted atropisomeric vinylarenes through a palladium−carbene pathway. This strategy utilizes 10 mol% p
Autor:
Daniel Rivalti, Carl A. Busacca, Bo Qu, Arindom Chatterjee, Nathan K. Yee, Nitinchandra D. Patel, Nizar Haddad, Chris H. Senanayake, Joshua D. Sieber, Frederic G. Buono, Sonia Rodriguez, Jean-Nicolas Desrosiers, Stefan Braith, Keith R. Fandrick, Heewon Lee
Publikováno v:
Asian Journal of Organic Chemistry. 6:1285-1291
Autor:
Liana Hie, Nelu Grinberg, Neil K. Garg, Chris H. Senanayake, Soumik Biswas, Olga V. Zatolochnaya, Nathan K. Yee, Sonia Rodriguez, Jean-Nicolas Desrosiers, Heewon Lee, Nizar Haddad
Publikováno v:
Angewandte Chemie International Edition. 55:11921-11924
A nickel-catalyzed Heck cyclization for the construction of quaternary stereocenters is reported. This transformation is demonstrated in the synthesis of 3,3-disubstituted oxindoles, which are prevalent motifs seen in numerous biologically active mol
Autor:
Veronica V. Angeles‐Dunham, Dimitry Kurouski, Nelu Grinberg, Joshua D. Sieber, Chris H. Senanayake, Nathan K. Yee, Daniel R. Fandrick, Anita E. Mattson, Heewon Lee, Nizar Haddad, Jinhua J. Song, Divya Chennamadhavuni
Publikováno v:
Advanced Synthesis & Catalysis. 358:3062-3068
Autor:
Marisa C. Kozlowski, Xingzhong Zeng, Bo Qu, Nizar Haddad, Jean-Nicolas Desrosiers, Xudong Wei, Nelu Grinberg, Heewon Lee, Osvaldo Gutierrez, Frank Roschangar, Jolaine Savoie, Nathan K. Yee, Jinhua J. Song, Chris H. Senanayake
Publikováno v:
Chemical Science. 7:5581-5586
The direct arylation of pyridine substrates using non-precious catalysts is underdeveloped but highly desirable due to its efficiency to access important motifs while being extremely cost-effective. The first nickel-catalyzed C-3 direct arylation of
Autor:
Jinhua J. Song, Bachir Latli, Matt Hrapchak, Xiao-Jun Wang, Chris H. Senanayake, Heewon Lee, Scot Campbell
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:687-694
Empagliflozin, (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol was recently approved by the FDA for the treatment of chronic type 2 diabetes mellitus. Herein, we report the synthesis of
Autor:
Xingzhong Zeng, Frederic G. Buono, Sonia Rodriguez, Keith R. Fandrick, Shengli Ma, Yibo Xu, Bo Qu, Melissa A. Herbage, Nizar Haddad, Zhengxu S. Han, Nathan K. Yee, Heewon Lee, Chris H. Senanayake, Nelu Grinberg
Publikováno v:
Advanced Synthesis & Catalysis. 356:301-307
A series of efficient ruthenium catalysts has been developed for the asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and selectivities. The new chiral bisdihydrobenzooxaphosphole (BIBOP)/diamine-ruthenium complex