Zobrazeno 1 - 10
of 23
pro vyhledávání: '"William Johnson"'
Autor:
Satoshi Yoda, Wafa Malik, Adam Langenbucher, Justin F. Gainor, Sai-Hong Ignatius Ou, Kylie Prutisto-Chang, Ramin Sakhtemani, Jennifer L Peterson, Aaron N. Hata, Alexander Drilon, Andrew Do, Jessica J. Lin, Adam J. Schoenfeld, Viola W. Zhu, Ted William Johnson, Jochen K. Lennerz, Lecia V. Sequist, Noura J. Choudhury, Ibiayi Dagogo-Jack, Subba R. Digumarthy, Christina Falcon, Charlotte E. Lee, Alice T. Shaw, Michael S. Lawrence, Beow Y. Yeap, Jennifer S. Temel, Harper Hubbeling
Publikováno v:
Clin Cancer Res
Purpose: Current standard initial therapy for advanced, ROS proto-oncogene 1, receptor tyrosine kinase fusion (ROS1)-positive (ROS1+) non–small cell lung cancer (NSCLC) is crizotinib or entrectinib. Lorlatinib, a next-generation anaplastic lymphoma
Autor:
Brian J. Wilkinson, William Johnson, Joanne M. Dupre, Zhong Li, John E. Gustafson, Alexander V. Ulanov
Publikováno v:
Food Microbiology. 82:46-52
Although Staphylococcus aureus is a major cause of food poisoning, little is known about its response to growth on food. Utilizing a transcriptional profiling and metabolomics approach, we compared S. aureus grown on autoclaved chicken breast (ACB) t
Autor:
Michael R. Collins, Paul F. Richardson, Neal W. Sach, Ted William Johnson, Jeff Elleraas, Jason Ewanicki
Publikováno v:
Angewandte Chemie. 128:3654-3659
Lorlatinib (PF-06463922) is an ALK/ROS1 inhibitor and is in clinical trials for the treatment of ALK positive or ROS1 positive NSCLC (i.e. specific subsets of NSCLC). One of the laboratory objectives for this molecule indicated that it would be desir
Autor:
Amy Stanford, Sigrun Hallmeyer, Beata Korytowsky, Stephen S. Johnston, Elisabetta Malangone-Monaco, William Johnson, Tony Okoro
Publikováno v:
Journal of Cancer Therapy. :335-343
As the treatment landscape for advanced melanoma continues to evolve, it is critical to focus on unmet needs and understand the cost of therapy. While Ipilimumab (IPI), an immunotherapy indicated for unresectable advanced melanoma, has been a mainsta
Publikováno v:
Journal - American Water Works Association. 110
Legionella was monitored in reclaimed water systems and were detected by culture in 50% of 115 samples, while 80% of the samples were positive by quantitative polymerase chain reaction (qPCR). The lowest level of Legionella was in a system that pract
Autor:
Paul G. Richardson, Phuong Le, Benjamin J. Burke, Ted William Johnson, Sacha Ninkovic, Ketan S. Gajiwala, Maria Angelica Linton
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:3408-3413
Incorporation of nitrogen is a common medicinal chemistry tactic to reduce log D values. Neighboring group participation influences log D , so the results are isomer dependent. The log D and log P differences observed between isomeric pyrimidines 1 ,
Autor:
Qinghai Peng, Tran Khanh Tuan, Atsuo Kuki, Steven P. Tanis, Zhang Junhu, Deepak Dalvie, Yang Anle, Xiaoming Yu, Jim Solowiej, Ted William Johnson, Hai Wang, Wen Liu, Plewe Michael Bruno, Buwen Huang, Graham L. Smith, Jon E. Kuehler, Klaus Ruprecht Dress, Chunfeng Yin, Qiyue Hu, Dorothy Delisle, Huichun Zhu, Scott L. Butler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7429-7434
HIV-1 integrase is one of three enzymes encoded by the HIV genome and is essential for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Recently, we reported the discovery of azaindole hydroxamic acids
Autor:
Qinghai Peng, Nowlin Dawn Marie, Hieu Lam, Ted William Johnson, Yang Anle, Wen Liu, Atsuo Kuki, Steven P. Tanis, Jon E. Kuehler, Zhang Junhu, Hai Wang, Plewe Michael Bruno, Scott L. Butler, Tran Khanh Tuan, Qiyue Hu, Sadayappan V. Rahavendran, Klaus Ruprecht Dress
Publikováno v:
Journal of Medicinal Chemistry. 52:7211-7219
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication. Recently, HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Herein, we report the discovery of azaindole carboxyli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5560-5564
The Golden Triangle is a visualization tool developed from in vitro permeability, in vitro clearance and computational data designed to aid medicinal chemists in achieving metabolically stable, permeable and potent drug candidates. Classifying compou
Autor:
William Johnson, Lo Tan
Publikováno v:
Ozone: Science & Engineering. 23:393-400
Ozone oxidation and pressurized biologically active filtration treatments were tested for the removal of organic color and by-products from a highly colored groundwater. Ozone oxidation greatly reduced the color level of untreated groundwater. Follow