Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tohru Sugawara"'
Publikováno v:
Primates. 51:285-289
Bitter taste perception evolved as a key detection mechanism against the ingestion of bioactive substances, and is mediated by TAS2R gene family members in vertebrates. The most widely known and best studied bitter substance is phenylthiocarbamide (P
Publikováno v:
Chemical and Pharmaceutical Bulletin. 49:1138-1146
An improved general method for automated synthesis of tripeptides was developed, in which methanesulfonic acid (MSA) was used in place of trifluoroacetic acid (TFA), thus making it possible to avoid, 1) corrosion of the apparatus by strong acid vapor
Publikováno v:
Chemical and Pharmaceutical Bulletin. 49:1147-1154
An in-house developed automated synthesis suite was used to prepare a library of 72 tetrapeptide derivatives, the starting materials for pharmaceutically attractive pentapeptides, employing a convergent strategy. An initial set of 18 dipeptides were
Publikováno v:
Biochemistry. 40:914-919
To gain insight into the origin of the difference in isoelectric point (pI) values for wild-type human interleukin-2 (IL-2) and IL-2 with an additional methionine residue at the N-terminus (Met-IL-2), conformational properties of the two molecular fo
Publikováno v:
Chemical and Pharmaceutical Bulletin. 48:784-792
TAK-218 has a 2,3-dihydrobenzofuran-5-amine (coumaran) structure which resembles alpha-tocopherol, and is a promising candidate as an agent for central nervous system (CNS) trauma and ischemia. The radical scavenging activity of TAK-218 was studied u
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:1272-1280
An automated synthesis system, which is suitable for repetitive syntheses using similar reaction procedures, was used to synthesize systematically a library of all possible dipeptides (25) and tripeptides (125) from 5 protected amino acids. The appar
Publikováno v:
ChemInform. 27
An automated synthesis system, which is suitable for repetitive syntheses using similar reaction procedures, was used to synthesize systematically a library of all possible dipeptides (25) and tripeptides (125) from 5 protected amino acids. The appar
Publikováno v:
The Journal of Automatic Chemistry
A versatile automated synthesis apparatus, equipped with a chemical artificial intelligence, was developed to prepare and isolate a wide variety of compounds. The apparatus was to the synthesis of substituted N-(carboxyalkyl)amino-acids. The apparatu
Autor:
Yasuhiko Kawano, Tohru Sugawara, Hirotomo Masuya, Noriyoshi Noguchi, Taisuke Matsuo, Michihiko Ochiai
Publikováno v:
Chemical and Pharmaceutical Bulletin. 31:2200-2208
As a key intermediate for the synthesis of sulfazecin derivatives, 3-amino-3-methoxy-2-azetidinone (24 or 26) was synthesized from penicillins, and various new compounds, including sulfazecin, were synthesized by acylation and sulfonation of 24 or 26
Publikováno v:
The Journal of Automatic Chemistry
A versatile automated apparatus, equipped with an artificial intelligence has been developed which may be used to prepare and isolate a wide variety of compounds. The prediction of the optimum reaction conditions and the reaction control in real time