Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Timothy J. Mitchison"'
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Traditional herbal medicines, which emphasize a holistic, patient-centric view of disease treatment, provide an exciting starting point for discovery of new immunomodulatory drugs. Progress on identification of herbal molecules with proven single age
Autor:
Margaret Coughlin, Christine M. Field, Martin Wühr, Matthew Sonnett, Lillia V. Ryazanova, Timothy J. Mitchison, James F. Pelletier
Crowding increases the tendency of macromolecules to aggregate and phase separate, and high crowding can induce glass-like states of cytoplasm. To explore the effect of crowding in a well-characterized model cytoplasm we developed methods to selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::580b72732eea8a64abee9cb4032b42d9
https://doi.org/10.1101/2021.04.11.439352
https://doi.org/10.1101/2021.04.11.439352
Autor:
Kenichi Shimada, Richard Ventura, Ho-Chou Tu, Iris Ngan, Peter D. Koch, Harding H. Luan, Ruomu Jiang, Jui-Hsia Weng, Timothy J. Mitchison
Publikováno v:
Nat Metab
Colchicine has served as a traditional medicine for millennia and remains widely used to treat inflammatory and other disorders. Colchicine binds tubulin and depolymerizes microtubules, but it remains unclear how this mechanism blocks myeloid cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdce534c1920a55986f747bb5efad20
https://europepmc.org/articles/PMC8175070/
https://europepmc.org/articles/PMC8175070/
Autor:
Luke Utley, Kaiko Kunii, Danielle J. Blackwell, Ryan Abo, Jan-Rung Mo, Mario Niepel, Yue Ren, David Church, Joseph M. Gozgit, Kevin Wayne Kuntz, Patricia E. Rao, Kerren Kalai Swinger, Jeff Song, Melissa Vasbinder, Kristy Kuplast-Barr, Victoria M. Richon, Timothy J. Mitchison, Christina R. Majer, Alvin Lu, Bin Gui, Jennifer R. Molina, Elena Minissale, Heike Keilhack, Tim J. Wigle, Ellen Bamberg
Publikováno v:
Cancer Research. 81:48-48
Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in oncology. The PARP family consists of seventeen enzymes that regulate fundamental biological processes in
Autor:
Harding H. Luan, Peter D. Koch, Ruomu Jiang, Richard Ventura, Jui-Hsia Weng, Kenichi Shimada, Ho-Chou Tu, Iris Ngan, Timothy J. Mitchison
Publikováno v:
Nature Metabolism. 3:728-728
Autor:
Timothy J. Mitchison, Kenichi Shimada
Publikováno v:
Molecular Systems Biology
Molecular Systems Biology, Vol 15, Iss 2, Pp n/a-n/a (2019)
Molecular Systems Biology, Vol 15, Iss 2, Pp n/a-n/a (2019)
The liver and kidney in mammals play central roles in protecting the organism from xenobiotics and are at high risk of xenobiotic‐induced injury. Xenobiotic‐induced tissue injury has been extensively studied from both classical histopathological
Autor:
Naren Tallapragada, Yuyu Song, Hallie Kuhn, Miles A. Miller, Hannes Mikula, Timothy J. Mitchison, Javier Pineda, Ralph Weissleder
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(48)
Drug receptor site occupancy is a central pharmacology parameter that quantitatively relates the biochemistry of drug binding to the biology of drug action. Taxanes and epothilones bind to overlapping sites in microtubules (MTs) and stabilize them. T
Publikováno v:
ACS Chemical Biology. 11:1544-1551
The genetic integrity of each organism is intimately tied to the correct segregation of its genome during mitosis. Insights into the underlying mechanisms are fundamental for both basic research and the development of novel strategies to treat mitosi
Autor:
Kenichi Shimada, Timothy J. Mitchison
BackgroundLiving organisms are constantly exposed to toxic xenobiotics and have therefore evolved protective responses. In mammals, the liver and kidney play central roles in protecting the organism from xenobiotics, and are at high risk of xenobioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fedf859f7e4de9359260164fa8ddb46
Autor:
David W. Frederick, Joseph A. Baur, Sheng Hui, Karthikeyani Chellappa, Joshua D. Rabinowitz, William J. Quinn, Timothy J. Mitchison, Le Zhan, Kristin A. Krukenberg, Xiaoyang Su, Ling Liu, Philip Redpath, Marie E. Migaud, Eileen White
The redox cofactor nicotinamide adenine dinucleotide (NAD) plays a central role in metabolism and is a substrate for signaling enzymes including poly-ADP-ribose-polymerases (PARPs) and sirtuins. NAD concentration falls during aging, which has trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aee0c901e93dbe5c0801a3154280e8
https://europepmc.org/articles/PMC5932087/
https://europepmc.org/articles/PMC5932087/