Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tao, Xin"'
Autor:
Li Jian, Luo Wei, Kun-Lin Liu, Chao Gao, Huang Zhigang, Luoting Yu, Cui-Ting Peng, Chen Shuhui, Tao Xin, Charles Z. Ding
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2511-2515
New analogues of antitubercular drug Delamanid were prepared, seeking drug candidates with enhanced aqueous solubility and high efficacy. The strategy involved replacement of phenoxy linker proximal to the 2-nitroimidazooxazole of Delamanid by piperi
Autor:
Jia-Ze Cheng, Xiao-Tao Xin
Publikováno v:
Journal of Coordination Chemistry. 71:3565-3574
A new Zn(II) metal-organic framework (MOFs), [Zn(BTC)(HME)]·(DMAc)(H2O) (1, H3BTC =1,3,5-benzenetricarboxylic acid, HME = protonated melamine, DMAc = N,N-dimethylacetamide), has been synthesized un...
Autor:
Luoting Yu, Fu Zhifei, Lichun Wang, Zhengxian Gu, Wang Jianfei, Ning-Yu Wang, Yang Zhang, Chen Shuhui, Tao Xin
Publikováno v:
Antimicrob Agents Chemother
Amphihevir, a benzofuran derivative, is the first reported hepatitis C virus (HCV) nonstructural protein 4B (NS4B) inhibitor that has advanced to clinical trials (currently in phase Ib trial [CTR20170632]). Here, we report the results of a preclinica
Autor:
Weixi Shen, Qiuying Jiang, Yinghua Jin, Chunhong Chen, Xiaowei Song, Yu Hu, Yuanyuan Guan, Tao Xin, Jingfang Wang, Li Zhong
Publikováno v:
International Journal of Biological Macromolecules. 104:681-686
The purpose of this study is to investigate the effect of a purified polysaccharide (PPPF) from pumpkin fruit on the Janus activated kinase (JAK)/signal transducer and activator of transcription (STAT) signaling during apoptotic process. The results
Autor:
Qiuying Jiang, Li Li, Tao Xin, Ying Liu, Chengjuan Fan, Chong Teng, Lingxiao Wei, Yanju Lv, Xiaowei Song, Dayong Huang, Yinghua Jin, Weixi Shen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
The poor prognosis in non-small-cell lung cancer has driven the development of novel targeted therapies. Vascular endothelial growth factor is the most potent force in mediating tumor angiogenesis, and many angiogenesis inhibitors have been developed
Publikováno v:
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, 16(34), 6306-6315
Organic and Biomolecular Chemistry, 16(34), 6306-6315
The development of γ-thionorleucine (ThioNle) as a handle for native chemical ligation-desulfurization is reported here. ThioNle is a new addition to the expanding thiolated amino acid toolbox and serves as a methionine substitute in NCL with the ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ff2c3d36504165146a1a14fdbc069e
https://doi.org/10.1039/c8ob01627e
https://doi.org/10.1039/c8ob01627e
Publikováno v:
Chemical Communications. 52:6079-6082
The Rh(ii)-catalyzed sulfur ylide [1,2]-rearrangement of carbenoids generated from aryldiazoacetates has been realized via N-S bond insertion, generating tertiary sulfides in moderate to excellent yields. This demonstrates the first use of the sulfur
Publikováno v:
Pharmacognosy Magazine. 16:51
Background: Parkinson's disease (PD) is one of the foremost neurological disorders which is differentiated next to the progressive dopamine (DA) loss, especially in the area of substantia nigra pars compacta (SNpc). Aberrant neuroinflammation, as wel
Autor:
Lenka Besse, Andrej Besse, Jürgen Bader, Bo-Tao Xin, Gerjan de Bruin, Marianne Kraus, Christoph Driessen, Herman S. Overkleeft, Elmer Maurits, Max Mendez-Lopez
Publikováno v:
Cell Chemical Biology, 26(3), 340-351
Proteasome inhibitors (PIs) are a backbone of multiple myeloma (MM) therapy. The proteasome harbors six proteolytically active subunits (β1, β2, β5), while β5 was identified as rate-limiting and is a primary target of clinically available PIs. Th
Autor:
Bogdan I. Florea, Kimberly M. Bonger, Selma Eising, Jurriaan J. A. Heming, Fleur Kleinpenning, Bo-Tao Xin, Herman S. Overkleeft
Publikováno v:
ChemBioChem, 19, 1648-1652
ChemBioChem, 19, 15, pp. 1648-1652
ChemBioChem, 19, 15, pp. 1648-1652
Bioorthogonal chemistry can be used for the selective modification of biomolecules without interfering with any other functionality that might be present. Recent developments in the field include orthogonal bioorthogonal reactions to modify multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e157f8cb2fb482ae1ded825ef594be
http://hdl.handle.net/2066/194248
http://hdl.handle.net/2066/194248