Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Suhendan Ekmekcioglu"'
Autor:
Jason Roszik, Dai Ogata, Keiji Tanese, Roland L. Bassett, Sun-Hee Kim, Lauren E. Haydu, Junna Oba, Suhendan Ekmekcioglu, Elizabeth A. Grimm
Publikováno v:
Cancers, Vol 12, Iss 3754, p 3754 (2020)
Cancers
Volume 12
Issue 12
Cancers
Volume 12
Issue 12
Innate inflammatory features have been found in melanoma tumors from patients at all stages, and molecular analysis has identified definitive inflammatory proteins expressed by tumors cells in patients who presents the worst prognosis. We have previo
Over the last decade, remarkable progress has been made in the areas of targeted therapy and immunotherapy for the treatment of cancer patients. However, durable clinical benefit has occurred only in a subset of responding patients. In our field of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b6b143320872df2afb3d447e943c2d3
https://doi.org/10.1016/b978-0-12-816545-4.00006-2
https://doi.org/10.1016/b978-0-12-816545-4.00006-2
Autor:
Sun-Hee Kim, Zhen Ding, Dai Ogata, Jason Roszik, Suhendan Ekmekcioglu, Elizabeth A. Grimm, Yong Qin
Publikováno v:
Cancer Research. 80:B09-B09
Based on our previous finding that inflammation associated nitric oxide synthase (NOS) expression in melanoma and its association with poor prognosis in melanoma patients, we investigated the role of nitric oxide (NO) on the PI3K-Akt pathway. Human m
Autor:
John Hicks, Suhendan Ekmekcioglu, Willem W. Overwijk, Paramahamsa Maturu, Elizabeth A. Grimm, Vicki Huff
Publikováno v:
Translational Oncology, Vol 7, Iss 4, Pp 484-492 (2014)
Translational Oncology
Translational Oncology
The role of inflammation in cancer has been reported in various adult malignant neoplasms. By contrast, its role in pediatric tumors has not been as well studied. In this study, we have identified and characterized the infiltration of various inflamm
Autor:
Gerald Steven Falchook, Luis H. Camacho, Goldy C. George, David S. Hong, Siqing Fu, Wen Liu, Kirk S. Culotta, Aung Naing, Kenna Lynn Anderes, Sarina Anne Piha-Paul, Jennifer J. Wheler, Susan Percy Ivy, Stacy Moulder, Suhendan Ekmekcioglu, Razelle Kurzrock, Yuejin Wen, Apostolia Maria Tsimberidou, Ignacio Garrido-Laguna, Darren W. Davis
Publikováno v:
Cancer. 120:2164-2173
BACKGROUND The current study was conducted to evaluate the safety and biological activity of dual inhibition of the vascular endothelial growth factor (VEGF) pathway with combined bevacizumab and cediranib (a VEGF receptor tyrosine kinase inhibitor).
Autor:
Christopher L. Schardon, Yun Wang, Abdul M. Gabisi, Arturo J. Cardounel, Walter Fast, Suhendan Ekmekcioglu, Shougang Hu, Gayle Burstein, Arthur J. Pope, Joyce A.V. Er
Publikováno v:
ChemMedChem. 9:792-797
Inhibitors of the human enzyme dimethylarginine dimethylaminohydrolase-1 (DDAH-1) can raise endogenous levels of asymmetric dimethylarginine (ADMA) and lead to a subsequent inhibition of nitric oxide synthesis. Herein, N5-(1-imino-2-chloroethyl)-L-or
Publikováno v:
Clinical Cancer Research. 19:5557-5563
It is widely accepted that many cancers express features of inflammation, driven by both microenvironmental cells and factors, and the intrinsic production of inflammation-associated mediators from malignant cells themselves. Inflammation results in
Publikováno v:
Melanoma Research. 21:44-56
Interleukin-24 (IL-24) is a novel tumor suppressor/cytokine gene expressed in normal human melanocytes but for which expression is nearly undetectable in metastatic melanoma. Overexpression of the IL-24 protein has been shown to inhibit tumor cell pr
Autor:
Padmini Jayaraman, Jeffrey N. Myers, Suhendan Ekmekcioglu, Yared Hailemichael, Andrew G. Sikora, John Kwon, Michael A. Davies, Elizabeth A. Grimm, Willem W. Overwijk, Alexander Gelbard, Daisuke Sano
Publikováno v:
Clinical Cancer Research. 16:1834-1844
Purpose: Aberrant expression of inflammatory molecules, such as inducible nitric oxide (NO) synthase (iNOS), has been linked to cancer, suggesting that their inhibition is a rational therapeutic approach. Whereas iNOS expression in melanoma and other
Autor:
Julie A. Ellerhorst, Suhendan Ekmekcioglu, Elizabeth A. Grimm, Marcella M. Johnson, Victor G. Prieto, Lyle D. Broemeling
Publikováno v:
International Journal of Cancer. 119:861-866
Inducible nitric oxide synthase (iNOS) produces nitric oxide, which has growth promoting activity in melanoma. A preliminary study of tumors from patients with Stage III melanoma who had received neo-adjuvant therapy revealed an association of tumor