Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Shingo Kajimura"'
Autor:
Shingo Kajimura, Anthony R.P. Verkerke
Publikováno v:
Dev Cell
Brown and beige adipocytes, or thermogenic fat, were initially thought to be merely a thermogenic organ. However, emerging evidence suggests its multifaceted roles in the regulation of systemic glucose and lipid homeostasis that go beyond enhancing t
Autor:
James S. V. Lally, Gregory R. Steinberg, Andrew G. McArthur, Evangelia E. Tsakiridis, Brennan K. Smith, Michael G. Wade, Katherine M. Morrison, Julian M. Yabut, Bo Wang, Shuman Zhang, Krishna A Srinivasan, Jagdish Suresh Patel, Alison C. Holloway, Shingo Kajimura, Eric M. Desjardins, Amogelang R. Raphenya, Emily A. Day, Alex E. Green, Andrea Llanos, Jianhan Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Obesity results from a caloric imbalance between energy intake, absorption and expenditure. In both rodents and humans, diet-induced thermogenesis contributes to energy expenditure and involves the activation of brown adipose tissue (BAT). We hypothe
Autor:
Shingo Kajimura
Publikováno v:
Proc Natl Acad Sci U S A
Adipose tissue is a highly plastic organ that dynamically changes its tissue size, cellular composition, and function in response to various nutritional and hormonal changes. For instance, white adipose tissue (WAT) can expand its volume by 10 times
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e040d54b4cbb4dd79501af3dd202352
https://europepmc.org/articles/PMC8053925/
https://europepmc.org/articles/PMC8053925/
Autor:
Shuman Zhang, Julian M. Yabut, Gregory R. Steinberg, Alison C. Holloway, Andrea Llanos, Alex E. Green, Bo Wang, Eric M. Desjardins, Brennan K. Smith, Evangelia E. Tsakiridis, Katherine M. Morrison, Shingo Kajimura, Amogelang R. Raphenya, Krishna A Srinivasan, Michael G. Wade, Jagdish Suresh Patel, Andrew G. McArthur, Emily A. Day, James S. V. Lally
Publikováno v:
Journal of the Endocrine Society
Obesity is a major risk factor for type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease that arises from a caloric surplus of as little as 10–30 kcal per day. And while increased consumption of energy dense fo
Autor:
Vanille J. Greiner, Michael T. McManus, Shingo Kajimura, Rachana N. Pradhan, Suneil K. Koliwad, Kazuki Tajima, Zachary Brown, Rachel T. Cheang, Bruce M. Spiegelman, Takeshi Yoneshiro, Ritwik Datta, Kamran Atabai, Christopher D Yang, Qiang Wang, Hyeonwoo Kim, Diana L. Alba, Kosaku Shinoda, Caroline R. Kim, Yasuo Oguri, W. Reid Bolus, Kazuyuki Tsujino, Yong Chen, Kenji Ikeda
Publikováno v:
Cell, vol 182, iss 3
Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91c20ee817bee8df20e47803951f57b
https://escholarship.org/uc/item/1fb2d4gg
https://escholarship.org/uc/item/1fb2d4gg
Autor:
Edward T. Chouchani, Shingo Kajimura
Publikováno v:
Nature metabolism. 1(2)
Adipose tissue possesses the remarkable capacity to control its size and function in response to a variety of internal and external cues, such as nutritional status and temperature. The regulatory circuits of fuel storage and oxidation in white adipo
Autor:
Daniel K. Nomura, Zachary Brown, Mark P. Jedrychowski, Makoto Takahashi, Yoko Yokoyama, Rachana N. Pradhan, Hiroshi Karasawa, Carlos H.G. Sponton, Qiang Wang, Mitsuhiro Watanabe, Yumi Matsui, Yong Chen, Hiroki Taoka, Kenji Ikeda, Kazuki Tajima, Kosaku Shinoda, Carl C. Ward, Takeshi Yoneshiro, Shingo Kajimura, Lindsay S. Roberts, Junki Taura, Yasuo Oguri, Takashi Hosono
Publikováno v:
EMBO Rep
While brown adipose tissue (BAT) is well-recognized for its ability to dissipate energy in the form of heat, recent studies suggest multifaced roles of BAT in the regulation of glucose and lipid homeostasis beyond stimulating thermogenesis. One of th
Autor:
Ken-ichi Hirata, Yushi Hirota, Wataru Ogawa, Akihiko Kondo, Yoshiharu Shimomura, Masayuki Saito, Seiichi Kitahama, Kengo Sasaki, Masakazu Shinohara, Tatsunori Osone, Shingo Kajimura, Takeshi Yoneshiro, Takuji Yamada, Tetsuya Hosooka, Yoshihiro Saito, Yasuyuki Kitaura, Takuo Emoto, Yuko Okamatsu-Ogura, Takeshi Inagaki, Tomohiro Suzuki, Genki Ozawa, Daisuke Sasaki, Naofumi Yoshida, Tomoya Yamashita
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103342-(2021)
iScience, Vol 24, Iss 11, Pp 103342-(2021)
Summary The gut microbiome has emerged as a key regulator of obesity; however, its role in brown adipose tissue (BAT) metabolism and association with obesity remain to be elucidated. We found that the levels of circulating branched-chain amino acids
Autor:
Shingo Kajimura, Lawrence Kazak, Dina Laznik-Bogoslavski, Bruce M. Spiegelman, Paul Cohen, Mark P. Jedrychowski, Sebastian C. Hasenfuss, Ramalingam Vetrivelan, Kosaku Shinoda, Edward T. Chouchani, Steve P. Gygi, Brian K. Erickson, Gina Z. Lu
Publikováno v:
Cell. 163:643-655
SummaryThermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to cold of brown and beige adipose depots are examined using qua
Autor:
Evanna L. Mills, Lawrence Kazak, Jessica B. Spinelli, Ryan Garrity, Steven P. Gygi, Takeshi Yoneshiro, Edward T. Chouchani, Marcia C. Haigis, Michael P. Murphy, Shingo Kajimura, Gina Z. Lu, Kerry A. Pierce, Mark P. Jedrychowski, Sara Vidoni, Sally Winther, Clary B. Clish, Alexander S. Banks
Brown and beige adipose tissue thermogenesis can combat metabolic disease, which requires activation by extrinsic stimuli(1). Adipocyte lipolysis through cAMP/PKA signaling initiates thermogenic respiration, and this pathway has been subject to longs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b187742acd648ac777c4242a0440d3
https://europepmc.org/articles/PMC7045287/
https://europepmc.org/articles/PMC7045287/