Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Richard H. Gomer"'
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:106-117
The active form of transforming growth factor-β1 (TGF-β1) plays a key role in potentiating fibrosis. TGF-β1 is sequestered in an inactive state by a latency-associated glycopeptide (LAP). Sialidases (also called neuraminidases (NEU)) cleave termin
Publikováno v:
Am J Pathol
High-fat diet (HFD)-induced inflammation is associated with a variety of health risks. The systemic pentraxin serum amyloid P (SAP) inhibits inflammation. SAP activates the high-affinity IgG receptor Fcγ receptor I (FcγRI; CD64) and the lectin rece
Autor:
Louis A. Cadena, Jacquelyn R. McCullough, David E. Zimmerhanzel, Richard H. Gomer, Ramesh Rijal, Yu Tang
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
mBio
mBio
Little is known about how eukaryotic cells can sense their number or spatial density and stop proliferating when the local density reaches a set value. We previously found that Dictyostelium discoideum accumulates extracellular polyphosphate to inhib
Publikováno v:
J Immunol
Fibrocytes are monocyte-derived fibroblast like cells that participate in wound healing, but little is known about what initiates fibrocyte differentiation. Blood platelets contain 60–100-mer polymers of phosphate groups called polyphosphate, and w
Publikováno v:
The Journal of Immunology. 202:239-248
The movement of neutrophils between blood and tissues appears to be regulated by chemoattractants and chemorepellents. Compared with neutrophil chemoattractants, relatively little is known about neutrophil chemorepellents. Slit proteins are endogenou
Publikováno v:
Proc Natl Acad Sci U S A
Polyphosphate is a linear chain of phosphate residues and is present in organisms ranging from bacteria to humans. Pathogens such as Mycobacterium tuberculosis accumulate polyphosphate, and reduced expression of the polyphosphate kinase that synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749a0cab74e817540be9eea3d199a4d3
https://europepmc.org/articles/PMC7749317/
https://europepmc.org/articles/PMC7749317/
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244762 (2020)
PLoS ONE
PLoS ONE
Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes and is characterized by the accumulation of fat in the liver (steatosis). NAFLD can transition into non-alcoholic steatohepatitis (NASH), with liver cell injury,
Publikováno v:
Molecular Biology of the Cell
Five or more orthophosphates bound together by high-energy phosphoanhydride bonds are highly ubiquitous inorganic molecules called polyphosphate. Polyphosphate acts as a signaling molecule eliciting a number of responses in eukaryotic cells, but the
Autor:
Katayoon Keyhanian, Donald James Fraser, Nehemiah Cox, Richard H. Gomer, Hannah E. Starke, Melisa Lopez-Anton, Sarah E. Herlihy
Publikováno v:
Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 36:367-373
Long-term peritoneal dialysis (PD) often results in the development of peritoneal fibrosis. In many other fibrosing diseases, monocytes enter the fibrotic lesion and differentiate into fibroblast-like cells called fibrocytes. We find that peritoneal
Publikováno v:
Proceedings of the National Academy of Sciences. 112:11929-11934
In healing wounds and fibrotic lesions, fibroblasts and monocyte-derived fibroblast-like cells called fibrocytes help to form scar tissue. Although fibrocytes promote collagen production by fibroblasts, little is known about signaling from fibroblast