Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Raghavendra G. Mirmira"'
Autor:
Myung Hee Park, Danielle A. Springer, Raghavendra G. Mirmira, Rajesh Kumar Kar, Teresa L. Mastracci, Matthew F. Starost, Ashleigh S. Hanner
Eukaryotic initiation factor 5A (eIF5A) is an essential factor with a unique amino acid, hypusine, required for its activity. Hypusine is formed exclusively in eIF5A by a post-translational modification involving two enzymes, deoxyhypusine synthase (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b366acb1eaa254f4d0251f7858d994dd
https://doi.org/10.1101/2021.05.11.443636
https://doi.org/10.1101/2021.05.11.443636
Autor:
Christien B. Dykstra, Bozena Samborska, Caroline S. Jiang, Paul Cohen, Lawrence Kazak, Olivia A. Maguire, Janane F. Rahbani, Matthew G. Annis, Xiaojing Huang, Adriana Rosas-Villegas, Sarah K. Szwed, Rebecca G. Gelfer, Peter M. Siegel, François Marchildon, Ji Dung Luo, Raghavendra G. Mirmira, Daniel J. Kramer, Sarah E. Ackerman, Aarthi V. Maganti, Victor Ceballos, Lauren E. Turner, Sarah A. Tersey, Andrew J. Dannenberg, Thomas L. Carroll, Asal Hejazi
Publikováno v:
Cell metabolism. 33(3)
Obesity is a major risk factor for adverse outcomes in breast cancer; however, the underlying molecular mechanisms have not been elucidated. To investigate the role of crosstalk between mammary adipocytes and neoplastic cells in the tumor microenviro
Autor:
Margaret M. Allaman, Thaddeus M. Smith, Yvonne L. Latour, Keith T. Wilson, Johanna C. Sierra, Thomas G. Verriere, Alberto G. Delagado, Mohammad Asim, Kristie L. Rose, M. Blanca Piazuelo, Kevin L. Schey, M. Wade Calcutt, Daniel P. Barry, Alain P. Gobert, Raghavendra G. Mirmira, Jordan L. Finley
Publikováno v:
Cell reports
Cell Reports, Vol 33, Iss 11, Pp 108510-(2020)
Cell Reports, Vol 33, Iss 11, Pp 108510-(2020)
SUMMARY Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation fac
Autor:
Jonàs Juan-Mateu, Ruichuan Yin, Farooq Syed, Yi Cui, Bobbie-Jo M. Webb-Robertson, Raghavendra G. Mirmira, Cailin Deiter, Jennifer E. Kyle, Julia Laskin, Lori Sussel, Ernesto S. Nakayasu, Carmella Evans-Molina, Kristin E. Burnum-Johnson, Michelle A. Guney, Charles Ansong, Decio L. Eizirik, Carrie D. Nicora, Thomas O. Metz, Galya Orr, Dylan Sarbaugh
SummaryLipids have been implicated as mediators of insulitis and β-cell death in type 1 diabetes development, but the mechanisms underlying this association are poorly understood. Here, we investigated the changes in islet/β-cell lipid composition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91af1ef1f0a65646bd8696a124e92bc0
Autor:
Fredrick M. Pavalko, Richard O. Day, Raghavendra G. Mirmira, Christopher A. Reissaus, Kathleen H. Day, Kenneth W. Dunn
Publikováno v:
Biophys J
We report the use of pulsed interleaved excitation-fluorescence lifetime imaging microscopy (PIE-FLIM) to measure the activities of two different biosensor probes simultaneously in single living cells. Many genetically encoded biosensors rely on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b320370581b80316e569aa3a5277f1bd
https://doi.org/10.1101/2020.01.10.902213
https://doi.org/10.1101/2020.01.10.902213
Autor:
Wenting Wu, Donalyn Scheuner, Teresa Mastracci, Abhishek Kulkarni, Ryan M. Anderson, Carmella Evans-Molina, Emily Anderson-Baucum, Isabel Casimiro, Raghavendra G. Mirmira, Sarah K. Tersey, Annie R. Piñeros, Bernhard Maier
Publikováno v:
SSRN Electronic Journal.
Obesity is characterized by adipose tissue expansion, macrophage infiltration, and the development of chronic low-grade meta-inflammation that drives insulin resistance and metabolic dysfunction. Eukaryotic translation initiation factor 5A (eIF5A) is
Autor:
Raghavendra G. Mirmira, Sarah K. Tersey, Thomas L. Carroll, Rebecca G. Gelfer, Lauren E. Turner, Asal Hejazi, Caroline S. Jiang, Olivia A. Maguire, Victor Ceballos, Ji-Dung Luo, Paul Cohen, Daniel J. Kramer, Adriana Rosas-Villegas, Christien B. Dykstra, Andrew J. Dannenberg, Aarthi V. Maganti, Janane F. Rahbani, François Marchildon, Sarah K. Szwed, Sarah E. Ackerman, Lawrence Kazak, Bozena Samborska, Xiaojing Huang
Publikováno v:
SSRN Electronic Journal.
Obesity is a major risk factor for adverse outcomes in breast cancer; however, the underlying molecular mechanisms have not been elucidated. To investigate the role of crosstalk between mammary adipocytes and neoplastic cells in the tumor microenviro
Autor:
Adolfo Garcia-Ocaña, Bernhard Maier, Donald K. Scott, Teresa L. Mastracci, Laura C. Alonso, Esther M. Levasseur, Raghavendra G. Mirmira, Farooq Syed, Emily Anderson-Baucum, Sarah A. Tersey, Amber L. Mosley, Annie R. Piñeros, Kara S. Orr, Kentaro Yamada, Wenting Wu, Ernesto Bernal-Mizrachi, Yunlong Liu
Publikováno v:
Sci Signal
Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically
Autor:
Sarah A. Tersey, Anna Neyman, Raghavendra G. Mirmira, Jennifer L. Nelson, Carmella Evans-Molina, Emily K. Sims
Publikováno v:
Diabetes, Obesity and Metabolism. 21:95-102
AIMS: DNA release by dying β cells leads to increased circulating levels of unmethylated preproinsulin (INS) DNA. Consistent with large-scale β cell destruction, this biomarker is elevated before and at the time of type 1 diabetes (T1D) onset. We m
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230627 (2020)
PLoS ONE, Vol 15, Iss 3, p e0230627 (2020)
The gene encoding eukaryotic initiation factor 5A (EIF5A) is found in diabetes-susceptibility loci in mouse and human. eIF5A is the only protein known to contain hypusine (hydroxyputrescine lysine), a polyamine-derived amino acid formed post-translat