Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Martin Egli"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 908-931 (2021)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to t
Publikováno v:
Nucleic Acids Research
Even in high-quality X-ray crystal structures of oligonucleotides determined at a resolution of 1 Å or higher, the orientations of first-shell water molecules remain unclear. We used cryo neutron crystallography to gain insight into the H-bonding pa
Autor:
Martin Egli, Terry P. Lybrand
Publikováno v:
Journal of the American Chemical Society. 141:4445-4452
Regiospecific replacement of a single phosphate (PO2) by a dithiophosphate (PS2) group in an RNA can dramatically increase its binding affinity for a target protein. Thus, complexes between antithrombin and anti-VEGF RNA aptamers with single dithioph
Autor:
Kallanthottathil G. Rajeev, Anna Bisbe, Gopal R Bommineni, Martin Egli, Lydia Perkins, Shigeo Matsuda, Martin Maier, Klaus Charisse, Dale C. Guenther, Muthiah Manoharan, Donald Foster, Joel M. Harp, Nate Taneja, Ivan Zlatev
Publikováno v:
Nucleic Acids Research. 46:8090-8104
Chemical modification is a prerequisite of oligonucleotide therapeutics for improved metabolic stability, uptake and activity, irrespective of their mode of action, i.e. antisense, RNAi or aptamer. Phosphate moiety and ribose C2'/O2' atoms are the mo
Publikováno v:
The Journal of organic chemistry. 86(1)
Design of Janus-faced or double-headed homoazanucleosides with the possibility to undergo self-organization through base pairing has been conceptualized and accomplished. The synthetic strategy demonstrates the unique ability to introduce two similar
Autor:
Hartmut Jahns, Terry P. Lybrand, Mark K Schlegel, Joel M. Harp, Martin Egli, Pradeep S. Pallan, Muthiah Manoharan
Publikováno v:
Biochemistry. 59(49)
GNRA (N = A, C, G, or U; R = A or G) tetraloops are common RNA secondary structural motifs and feature a phosphate stacked atop a nucleobase. The rRNA sarcin/ricin loop (SRL) is capped by G ApGA, and the phosphate p stacks on G . We recently found th
Autor:
Namrata D. Erande, Mark K Schlegel, Martin Egli, Atsushi Mikami, Tyler Chickering, Ivan Zlatev, Lauren Blair Woods, Alexander V Kel'in, Shigeo Matsuda, Pradeep S. Pallan, Muthiah Manoharan
Publikováno v:
Nucleic Acids Research
Various chemical modifications have been identified that enhance potency of small interfering RNAs (siRNAs) and that reduce off-target effects, immune stimulation, and toxicities of metabolites of these therapeutic agents. We previously described 5
Autor:
Amanda K. McCullough, Martin Egli, Vladimir Vartanian, R. Stephen Lloyd, Jongchan Yeo, Miral Dizdaroglu, Naoto N. Tozaki, Erdem Coskun, Sanem Hosbas Coskun, Michael P. Stone, Pawel Jaruga, Irina G. Minko, Sheila S. David
Publikováno v:
DNA Repair (Amst)
Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1 that converts a single adenosine to inosine, and this conversion results in an amino acid change of lysine 242 to arginine. Previous investigations of the catalytic efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce12a2f9822ce2bfccbaac7c1ec4b82
https://escholarship.org/uc/item/72z2t1bq
https://escholarship.org/uc/item/72z2t1bq
Publikováno v:
Crystals, Vol 9, Iss 10, p 532 (2019)
Crystals
Volume 9
Issue 10
Crystals
Volume 9
Issue 10
The (4&prime
&rarr
6&prime
)-linked DNA homolog 2&prime
3&prime
dideoxy-&beta
D-glucopyranosyl nucleic acid (dideoxy-glucose nucleic acid or homo-DNA) exhibits stable self-pairing of the Watson&ndash
Crick and rever
&rarr
6&prime
)-linked DNA homolog 2&prime
3&prime
dideoxy-&beta
D-glucopyranosyl nucleic acid (dideoxy-glucose nucleic acid or homo-DNA) exhibits stable self-pairing of the Watson&ndash
Crick and rever
Autor:
Barbara Nawrot, Rafał Dolot, Qiang Zhao, Martin Egli, Malgorzata Sierant, Curtis H. Lam, Xianbin Yang, Feng-Wu Liu
Publikováno v:
Nucleic Acids Research
Thrombin-binding aptamer (TBA) is a DNA 15-mer of sequence 5′-GGT TGG TGT GGT TGG-3′ that folds into a G-quadruplex structure linked by two T-T loops located on one side and a T-G-T loop on the other. These loops are critical for post-SELEX modif