Zobrazeno 101 - 110
of 134
pro vyhledávání: '"Martin Egli"'
Autor:
Martin Egli, Robert L. Eoff, Carmelo J. Rizzo, F. Peter Guengerich, Ivan D. Kozekov, Huidong Zhang
Publikováno v:
The Journal of biological chemistry. 284(6)
In contrast to replicative DNA polymerases, Sulfolobus solfataricus Dpo4 showed a limited decrease in catalytic efficiency (kcat/Km) for insertion of dCTP opposite a series of N2-alkylguanine templates of increasing size from (methyl (Me) to (9-anthr
Methylation of the exocyclic amino group of guanine is a relatively common modification in rRNA and tRNA. Single methylation (N2-methylguanosine, m2G) is the second most frequently encountered nucleoside analog in Escherichia coli rRNAs. The most pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ee58dac722f7dbd2d43177b6fecf8d
https://europepmc.org/articles/PMC2578855/
https://europepmc.org/articles/PMC2578855/
Autor:
Feng Li, Martin Egli, Manjori Ganguly, Luis A. Marky, Barry Gold, Michael P. Stone, Feng Wang
Site-specific insertion of 5-(3-aminopropyl)-2'-deoxyuridine (Z3dU) and 7-deaza-dG into the Dickerson-Drew dodecamers 5'-d(C (1)G (2)C (3)G (4)A (5)A (6)T (7)T (8)C (9) Z (10)C (11)G (12))-3'.5'-d(C (13)G (14)C (15)G (16)A (17)A (18)T (19)T (20)C (21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2931fb3cf94e67410fc1dedd82e9d9
https://europepmc.org/articles/PMC2730145/
https://europepmc.org/articles/PMC2730145/
Autor:
P Bash, Martin Egli, G Qi, Christin A. Frederick, Loren Dean Williams, G. A. Van Der Marel, J. H. Van Boom, Alexander Rich
Publikováno v:
Proceedings of the National Academy of Sciences. 87:2225-2229
The anthracycline antibiotic nogalamycin, which binds to DNA, is composed of a planar aglycone substituted on each end to form an unusual dumbbell-shaped molecule. At one end nogalamycin contains an uncharged nogalose sugar and a methyl ester. At the
Publikováno v:
The Journal of biological chemistry. 282(50)
The 2,4-difluorotoluene (DFT) analog of thymine has been used extensively to probe the relative importance of shape and hydrogen bonding for correct nucleotide insertion by DNA polymerases. As far as high fidelity (A-class) polymerases are concerned,
Autor:
Martin Egli, Pradeep S. Pallan
Publikováno v:
Nature protocols. 2(3)
This protocol describes a method for introducing an anomalously scattering atom into oligonucleotides at the 2'-position of uridine by conventional solid-phase synthesis. The 2'-SeMe ribose modification is particularly attractive for derivatization o
Publikováno v:
The Journal of biological chemistry. 282(2)
We examined the effect of a single O6-methylguanine (O6-MeG) template residue on catalysis by a model Y family polymerase, Dpo4 from Sulfolobus solfataricus. Mass spectral analysis of Dpo4-catalyzed extension products revealed that the enzyme accurat
Publikováno v:
Biochemistry. 45(26)
Among the hundreds of nucleic acid analogues that have been studied over the last two decades only very few exhibit backbones with linkers between residues that are either shorter or longer than the four-atom linker O3'-P-O5'-C5' connecting sugar rin
Autor:
Michael McGuire, Cristian Rodriguez-Aguayo, Archana S. Nagaraja, Sunila Pradeep, Anil K. Sood, Morgan Taylor, Kshipra Ghaupure, Malgorzata Sierant, Barbara Nawrot, Martin Egli, Sherry Y. Wu, Takahito Miyake, Xianbin Yang, Hiroto Hatakeyama, Prahlad T. Ram, Gabriel Lopez-Berestein, Richa Singhania, Nigel A.J. McMillan, Rajesha Rupaimoole
Publikováno v:
Cancer Research. 74:1406-1406
Improving small interfering RNA (siRNA) efficacy in target cell populations remains a critical challenge to bringing siRNA therapy into the clinic. There is currently an unmet need to develop a reliable strategy to globally enhance siRNA stability an
Autor:
Pradeep S. Pallan, George Minasov, Steve R. Owens, Valentina Tereshko, Elena A. Lesnik, Muthiah Manoharan, Gopal B. Inamati, Bruce S. Ross, Martin Egli, Thazha P. Prakash, Marianna Teplova
Publikováno v:
Biochemistry. 44(25)
The syntheses of 10 new RNA 2'-O-modifications, their incorporation into oligonucleotides, and an evaluation of their properties such as RNA affinity and nuclease resistance relevant to antisense activity are presented. All modifications combined wit