Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Manabu, Igarashi"'
Publikováno v:
PeerJ Physical Chemistry, Vol 3, p e19 (2021)
The substitution of Ile to Val at residue 117 (I117V) of neuraminidase (NA) reduces the susceptibility of the A/H5N1 influenza virus to oseltamivir (OTV). However, the molecular mechanism by which the I117V mutation affects the intermolecular interac
Autor:
Taksoo Kim, Manabu Igarashi, Shizuka Hirose, Norikazu Isoda, Yoshihiro Sakoda, Loc Tan Huynh, Takahiro Hiono
Publikováno v:
Viruses, Vol 13, Iss 1672, p 1672 (2021)
Viruses
Volume 13
Issue 8
Viruses
Volume 13
Issue 8
The GPE− strain is a live attenuated vaccine for classical swine fever (CSF) developed in Japan. In the context of increasing attention for the differentiating infected from vaccinated animals (DIVA) concept, the achievement of CSF eradication with
Publikováno v:
PeerJ
PeerJ, Vol 9, p e11552 (2021)
PeerJ, Vol 9, p e11552 (2021)
Background Oseltamivir (OTV)-resistant influenza virus exhibits His-to-Tyr mutation at residue 274 (H274Y) in N1 neuraminidase (NA). However, the molecular mechanisms by which the H274Y mutation in NA reduces its binding affinity to OTV have not been
Autor:
Shinichiro Nakamura, Yasushi Itoh, Misako Nakayama, Kazumasa Ogasawara, Masatoshi Okamatsu, Michiko Doi, Masanori Shiohara, Hiroshi Kida, Yoshihiro Sakoda, Hideaki Ishida, Hirohito Ishigaki, Akihiro Ishii, Naoko Kitagawa, Hideaki Tsuchiya, Manabu Igarashi, Shintaro Shichinohe, Takako Sasamura
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:4962-4973
The number of patients infected with H7N9 influenza virus has been increasing since 2013. We examined the efficacy of neuraminidase (NA) inhibitors and the efficacy of a vaccine against an H7N9 influenza virus, A/Anhui/1/2013 (H7N9), isolated from a
Autor:
Kimihito Ito, Yoshihiro Kawaoka, Ryo Takano, Masakazu Sekijima, Ayato Takada, Maki Kiso, Manabu Igarashi, Quynh Mai Le
Publikováno v:
The Journal of Infectious Diseases. 207:89-97
Background. The neuraminidase (NA) inhibitor oseltamivir is widely used to treat patients infected with influenza viruses. An Ile-to-Val change at position 117 in influenza A virus subtype H5N1 NA (NA-I117V) confers a reduction in susceptibility to o
Autor:
Kuniko Yaguchi, Chihiro Tachikawa, Shuzo Moritani, Manabu Igarashi, Masaaki Nomura, Ken-ichi Miyamoto, Koichi Yokogawa, Mikiko Imada, Satoshi Morito
Publikováno v:
Biological and Pharmaceutical Bulletin. 28(11):2040-2045
金沢大学医学部附属病院薬剤部
The stromal MC3T3-G2/PA6 (PA6) cells from mouse clavaria did not require insulin for differentiation into mature adipose cells, although insulin is well known to play a key role in adipocyte differentia
The stromal MC3T3-G2/PA6 (PA6) cells from mouse clavaria did not require insulin for differentiation into mature adipose cells, although insulin is well known to play a key role in adipocyte differentia
Publikováno v:
The Journal of Physical Chemistry A. 107:7505-7513
Ionization dynamics of trans-formanilide-water 1:1 complexes FA(H 2 O) have been investigated by means of direct ab initio trajectory method. From the static ab initio calculations, three conformers of the FA(H 2 O) complexes were obtained as stable
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 594:61-69
Temperature and solvation effects on the hyperfine coupling constants (HFCCs) of methyl radical have been investigated by means of direct ab initio molecular dynamics (MD) method. The complexes composed of methyl radical and H 2 O molecules, CH 3 (H
Publikováno v:
Chemical Physics Letters. 352:113-119
Temperature effects on the hyperfine coupling constants (hfcc's) of the methyl radical have been investigated by means of direct ab initio molecular dynamics (MD) method. The calculations showed that the hydrogen-hfcc (H-hfcc) of CH 3 increases with
Autor:
Manabu Igarashi, Satoko Yamanouchi, Yoshinori Makino, Rie Hasebe, Akihiko Maeda, Takashi Kimura, Hirofumi Sawa, Motohiro Horiuchi, Tadaki Suzuki
Publikováno v:
BMC Microbiology
BMC Microbiology, Vol 10, Iss 1, p 165 (2010)
BMC Microbiology, Vol 10, Iss 1, p 165 (2010)
Background West Nile virus (WNV) causes viremia after invasion to the hosts by mosquito bite. Endothelial cells could play an important role in WNV spread from the blood stream into the central nervous system and peripheral tissues. Here, we analyzed