Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Lawrence, N."'
Publikováno v:
Surgery. 169:678-685
Background Sexual dimorphism has been demonstrated after major trauma and hemorrhage shock with protective effects related to female sex or estrogen. Traumatic endotheliopathy is an important component of trauma-induced coagulopathy. Components of en
Autor:
Lawrence N. Hale, Timothy J. Muldoon, Narasimhan Rajaram, Elizabeth A. Bullard, Michael J. Fahr, Ariel I. Mundo, Gage J. Greening
Publikováno v:
Journal of Biomedical Optics
Significance: Many studies in colorectal cancer (CRC) use murine ectopic tumor models to determine response to treatment. However, these models do not replicate the tumor microenvironment of CRC. Physiological information of treatment response derive
Publikováno v:
Journal of Trauma and Acute Care Surgery. 84:575-582
Background Early resuscitation after trauma-hemorrhagic shock with plasma rather than crystalloid may ameliorate systemic endothelial cell (EC) injury and dysfunction (endotheliopathy of trauma). We postulated that endothelial-lined microfluidic netw
Publikováno v:
Journal of Trauma and Acute Care Surgery. 84:75-80
The endothelial glycocalyx (GCX) plays an important role in vascular barrier function. Damage to the GCX occurs due to a variety of causes including hypoxia, ischemia-reperfusion, stress-related sympathoadrenal activation, and inflammation. Tranexami
Autor:
Ethan Katznelson, Cyprien Shyirambere, Tharcisse Mpunga, Aline Umwizerwa, Lisa Bazzett-Matabele, Rebecca DeBoer, Lawrence N. Shulman, Victoria Umutoni, Scott A. Triedman, Jean Bosco Bigirimana, Diomede Ntasumbumuyange, Alan Paciorek, Cam Nguyen
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 30:46-46
Purpose: Cervical cancer is a leading cause of cancer-related mortality in Africa. As treatment capacity expands, it is critical to evaluate outcomes and identify targets for quality improvement. We describe a cohort of cervical cancer patients at Bu
Autor:
Asif Rashid, Peter Michaely, Heather Levin, Sang Soo Kim, Kirti Shetty, Lior H. Katz, Richard Amdur, Jian Chen, Hidekazu Tsukamoto, Lei Li, Vivek Shukla, Xiaoping Su, Alan Yaoqi Wang, Junjie Chen, Keigo Machida, Gottumukkala S. Raju, Patrizia Farci, Alexandros Tzatsos, John R. Stroehlein, Lawrence N. Kwong, Jon White, Bao Ngoc Nguyen, Wilma Jogunoori, Boris Blechacz, Marta L. Davila, Bibhuti Mishra, Lopa Mishra, Jaclyn Andricovich
Publikováno v:
Hepatology. 65:678-693
Exposure to genotoxins such as ethanol-derived acetaldehyde leads to DNA damage and liver injury, and promotes the development of cancer. We report here a major role for the TGF-β/Smad3 adaptor β2-Spectrin (β2SP, gene Sptbn1) in maintaining genomi
Publikováno v:
The journal of trauma and acute care surgery. 87(5)
Background Plasma is an important component of resuscitation after trauma and hemorrhagic shock (T/HS). The specific plasma proteins and the impact of storage conditions are uncertain. Utilizing a microfluidic device system, we studied the effect of
Publikováno v:
Journal of Trauma and Acute Care Surgery. 79:1015-1022
The mucus barrier is a critical component of the gut barrier and may be disrupted by pancreatic enzymes following trauma/hemorrhagic shock (T/HS). Luminal strategies against pancreatic enzyme activation or contact with the intestine are protective of
Publikováno v:
Journal of Trauma and Acute Care Surgery. 77:570-576
The incidence and severity of Clostridium difficile colitis have increased dramatically in the last decade. Disease severity is related to C. difficile virulence factors, including toxins A and B, as well as the patient's immune status. The intestina
Publikováno v:
Journal of Trauma and Acute Care Surgery. 77:40-46
Background Intestinal ischemia and reperfusion is a major problem associated with a high morbidity and mortality following trauma and hemorrhagic shock. Apoptosis is the major mode of cell death following reperfusion. The cytoskeleton damage precedes