Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Karel Souček"'
Autor:
Herbert Waldmann, Jana Flegel, Slava Ziegler, Barbora Valčíková, Stjepan Uldrijan, Sonja Sievers, Michaela Hylsová, Apirat Chaikuad, Stefan Knapp, Benedict-Tilman Berger, Lukáš Maier, Martin Schröder, Vaclav Nemec, Karel Souček, Stanislav Drápela, Kamil Paruch
Publikováno v:
Angewandte Chemie International Edition. 58:1062-1066
Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound
Publikováno v:
Cytometry Part A. 93:239-248
Complex analysis of cellular responses after experimental treatment is important for screening, mechanistic understanding of treatment effects, and the identification of sensitive and resistant cell phenotypes. Modern multicolor flow cytometry has de
Autor:
Václav Němec, Stefan Knapp, Apirat Chaikuad, Benedict-Tilman Berger, Stanislav Drápela, Kamil Paruch, Karel Souček, Lukáš Maier
Publikováno v:
European Journal of Medicinal Chemistry. 215:113299
The furo [3,2-b]pyridine motif represents a relatively underexplored central pharmacophore in the area of kinase inhibitors. Herein, we report flexible synthesis of 3,5-disubstituted furo [3,2-b]pyridines that relies on chemoselective couplings of ne
Autor:
Stanislav Drápela, Karel Souček, Erik Weis, Kamil Paruch, PrashantKumar Khirsariya, Michal Poljak, Santosh Kumar Adla, Ondřej Hylse, Soňa Krajčovičová, Lukáš Maier, Lenka Černová
Publikováno v:
The Journal of Organic Chemistry. 82:3382-3402
Carbocyclic C-nucleosides are quite rare. Our route enables flexible preparation of three classes of these nucleoside analogs from common precursors-properly substituted cyclopentanones, which can be prepared racemic (in six steps) or optically pure
Autor:
Zdeněk Andrysík, Radek Fedr, Josef Mašek, Miroslav Machala, Jan Topinka, Eva Hrubá, Simona Strapáčová, Lucie Svržková, Ondřej Vacek, Martina Hýžďalová, Jiří Kléma, Karel Souček, Jiřina Procházková, Jan Vondráček, Helena Libalova
Publikováno v:
Chemosphere. 263:128126
Deciphering the role of the aryl hydrocarbon receptor (AhR) in lung cancer cells may help us to better understand the role of toxic AhR ligands in lung carcinogenesis, including cancer progression. We employed human lung carcinoma A549 cells to inves
Autor:
Rastislav Jendželovský, Radek Fedr, Jaromír Mikeš, Karel Souček, Peter Fedoročko, Alois Kozubík, Lucia Mikešová, Barbora Kuchárová, Ján Remšík, Ľubomír Čulka, Jana Vargová
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 99
Objective Cancer stem-like cells (CSLCs) are considered a root of tumorigenicity and resistance. However, their identification remains challenging. The use of the side population (SP) assay as a credible marker of CSLCs remains controversial. The SP
Autor:
Michela Muscettola, Sara Salvadori, Nila Volpi, Emanuela Maioli, Karel Souček, Claudia Torricelli, Eva Slabáková, Giuseppe Valacchi
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012)
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-based Complementary and Alternative Medicine : eCAM
Since the ability of cancer cells to evade apoptosis often limits the efficacy of radiotherapy and chemotherapy, autophagy is emerging as an alternative target to promote cell death. Therefore, we wondered whether Rottlerin, a natural polyphenolic co
Autor:
Vítězslav Bryja, Miroslav Machala, Jan Topinka, Eva Hrubá, Karel Souček, Jan Vondráček, Helena Libalova
Publikováno v:
Toxicology Letters. 206:178-188
Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. In order to evaluate the complex r
Autor:
Jaromír Mikeš, Rastislav Jendželovský, Peter Fedoročko, Jiřina Procházková, Ján Koval, Karel Souček, Jiřina Hofmanová, Veronika Sačková, Alois Kozubík, Martin Kello
Publikováno v:
Photochemical & Photobiological Sciences. 8:1716-1723
Photodynamic therapy (PDT) is a flexible multi-target therapeutic approach. One of the main requirements of successful PDT is sufficient intracellular concentration of an applicable photosensitizer. Mechanisms of anticancer drug elimination by tumour
Autor:
Tomáš Bárta, Karel Šmejkal, Veronika Závalová, Jan Hošek, Pavlína Trnová, Peter Kollar, Aleš Hampl, Karel Souček, Stanislava Keltosova, Radek Fedr
Publikováno v:
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015)
Evidence-Based Complementary and Alternative Medicine, Vol 2015 (2015)
Aims. In this work we studied cytodifferentiation effects of newly characterized prenyl flavonoid 4′-O-methylkuwanon E (4ME) isolated from white mulberry (Morus albaL.).Main Methods. Cell growth and viability were measured by dye exclusion assay; c