Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Irene M. Ghobrial"'
Autor:
Nicholas Tsakmaklis, Aldo M. Roccaro, Timothy P White, Christopher J. Patterson, Guang Yang, Antonio Sacco, Xia Liu, Yang Cao, Zachary R. Hunter, Shayna Sarosiek, Carly Leventoff, Irene M. Ghobrial, Manit Munshi, Jorge J. Castillo, Lian Xu, Steven P. Treon, Catherine A Flynn, Kirsten Meid, Andrew R. Branagan, Amanda Kofides, Maria Luisa Guerrera, Maria Demos
Publikováno v:
Blood
MYD88 and CXCR4 mutations are common in Waldenström macroglobulinemia (WM). Mutated CXCR4 (CXCR4Mut) impacts BTK-inhibitor response. We conducted a phase 1 trial of the CXCR4-antagonist ulocuplumab with ibrutinib in this first-ever study to target C
Autor:
Jorge J. Castillo, Kirsten Meid, Maria Luisa Guerrera, Guang Yang, Irene M. Ghobrial, Steven P. Treon, Jacob D. Soumerai, Alan P Skarbnik
Publikováno v:
Blood. 135:1912-1915
Treon et al provide early clinical data supporting a theoretical rationale for continuing ibrutinib in patients receiving the drug during COVID-19 illness.
Autor:
Jordan Rossen, Alexandre Detappe, Mairead Reidy, John L. Markley, Mustafa Kocak, Prathapan Thiru, Kai Cai, Nora Kory, Irene M. Ghobrial, Guillaume Kugener, Weiwen Ying, Peter Tsvetkov, Luke Whitesell, Aviad Tsherniak, Zarina Brune, Susan Lindquist, Todd R. Golub, Sandro Santagata, Heather R. Keys
Publikováno v:
Nature chemical biology
The mechanisms by which cells adapt to proteotoxic stress are largely unknown, but are key to understanding how tumor cells, particularly in vivo, are largely resistant to proteasome inhibitors. Analysis of cancer cell lines, mouse xenografts and pat
Autor:
Philippe Armand, Damian R. Handisides, Irene M. Ghobrial, Jacalyn Rosenblatt, Kenneth C. Anderson, Jacquelyn Hedlund, Paul G. Richardson, Henry Dumke, Bradley Rivotto, Stacey Chuma, Robert L. Schlossman, Kenneth H. Shain, Stew Kroll, Patrick Henrick, Chia Jen Liu, Noopur Raje, Michael Gary Martin, Alexandra Savell, Andrew Yee, Craig Reynolds, Kalvis Hornburg, Laura Stampleman, Jacob P. Laubach, Ira Zackon
Publikováno v:
Clinical Cancer Research. 25:478-486
Purpose: The presence of hypoxia in the diseased bone marrow presents a new therapeutic target for multiple myeloma. Evofosfamide (formerly TH-302) is a 2-nitroimidazole prodrug of the DNA alkylator, bromo-isophosphoramide mustard, which is selective
Autor:
Kenneth C. Anderson, Clifton C. Mo, Omar Nadeem, Kelly Masone, Ella L Millard, Irene M. Ghobrial, Giada Bianchi, Mary McKenney, Isabella Hou, Peter Barth, Kathleen Colson, Jacob P. Laubach, Leyla Shune, Virginia Dalton, Paul G. Richardson, Adam S. Sperling, Robert A. Redd, Alexandra Savell, Vaishali Sanchorawala, Nikhil C. Munshi, Laura N. Amweg, Trevor J. Bayliss, Alexandra Distaso
Publikováno v:
Blood
Introduction: Treatment of relapsed and refractory multiple myeloma (RRMM) continues to evolve as most patients are lenalidomide (LEN) refractory at the time of first relapse with its widespread use in both induction and maintenance therapy. Pomalido
Autor:
Steven P. Treon, Christopher J. Patterson, Guang Yang, Jacob P. Laubach, Zachary R. Hunter, Andrew R. Branagan, Xia Liu, Irene M. Ghobrial, Kirsten Meid, Jorge J. Castillo, Lian Xu, Ranjana H. Advani, M. Lia Palomba, Joshua Gustine
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 39(6)
PURPOSE We report the long-term findings and final analysis of a pivotal multicenter trial of ibrutinib monotherapy in previously treated patients with Waldenström macroglobulinemia (WM). PATIENTS AND METHODS Sixty-three symptomatic patients with me
Autor:
Omar Nadeem, Alexandra Distaso, Kelly Masone, Sarah Patches, Vaishali Sanchorawala, Paul G. Richardson, Giada Bianchi, Trevor J. Bayliss, Jacob P. Laubach, Isabella Hou, Robert A. Redd, Mary McKenney, Kenneth C. Anderson, Irene M. Ghobrial, Lindsay Issokson, Nikhil C. Munshi, Anna Barrell, Clifton C. Mo, Virginia Dalton, Peter Barth, Adam S. Sperling, Leyla Shune
Publikováno v:
Blood. 138:1650-1650
Introduction: Ixazomib is an oral proteasome inhibitor (PI) that is currently approved to be administered once weekly in combination with lenalidomide (LEN) and dexamethasone in RRMM (Moreau et al N Eng J Med 2016; 374:1621-1634). As most patients ar
Autor:
Amanda Kofides, Nicholas Tsakmaklis, Irene M. Ghobrial, Zachary R. Hunter, Jorge J. Castillo, Romanos Sklavenitis-Pistofidis, Andrew Keezer, Xia Liu, Antonio Sacco, Gloria Chan, Jiaji G. Chen, Steven P. Treon, Christopher J. Patterson, Cristina Jimenez, Guang Yang, Lian Xu, Mark Bustoros, Maria Luisa Guerrera, Aldo M. Roccaro, Maria Demos, Joshua Gustine, Kirsten Meid, Andrew R. Branagan, Manit Munshi
Publikováno v:
J Clin Oncol
Next-generation sequencing has revealed recurring somatic mutations in Waldenström macroglobulinemia (WM), including MYD88 (95%-97%), CXCR4 (30%-40%), ARID1A (17%), and CD79B (8%-15%). Deletions involving chromosome 6q are common in patients with mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efca54b75e21278d2c174940e6f06e2
https://europepmc.org/articles/PMC7351339/
https://europepmc.org/articles/PMC7351339/
Autor:
Ofer Shpilberg, Irene M. Ghobrial, Moshe Mittelman, Ashraf Badros, Ivan Spicka, Arnon Nagler, Kenneth C. Anderson, Richard Leblanc, Jacob P. Laubach, Kihyun Kim, Teru Hideshima, Peter Sportelli, Paul Blake, Paul G. Richardson, Moshe E. Gatt, Merav Leiba, Sung-Soo Yoon, Michael Chen, Kathleen Colson, Roman Hájek, Hakan Kaya, Joaquin Martinez-Lopez, Parameswaran Hari, Dina Ben-Yehuda
Publikováno v:
EJHaem. 1(1)
Perifosine, an investigational, oral, synthetic alkylphospholipid, inhibits signal transduction pathways of relevance in multiple myeloma (MM) including PI3K/Akt. Perifosine demonstrated anti-MM activity in preclinical studies and encouraging early-p
Autor:
Alexandre Detappe, Aviad Tsherniak, Irene M. Ghobrial, Peter Tsvetkov, Kai Cai, Prathapan Thiru, Sandro Santagata, Heather R. Keys, Zarina Brune, Susan Lindquist, Mairead Reidy, Guillaume Kugener, Luke Whitesell, John L. Markley, Weiwen Ying
SUMMARYThe mechanisms used by cancer cells to resist the severe disruption in protein homeostasis caused by proteasome inhibitors remain obscure. Here, we show this resistance correlates with a metabolic shift from glycolysis to oxidative phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3b7176efc5970ff474b06de9bf7f40