Zobrazeno 1 - 10
of 15
pro vyhledávání: '"George Kemble"'
Autor:
Camila Manrique-Acevedo, George Kemble, Douglas Buckley, Elizabeth J. Parks, Ayman H. Gaballah, Ghassan M. Hammoud, Majid M. Syed-Abdul, William McCulloch, Kimberlee Bingham
Publikováno v:
Hepatology. 72:103-118
Background and aims Elevated hepatic de novo lipogenesis (DNL) is a key distinguishing characteristic of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis. In rodent models of NAFLD, treatment with a surrogate of TVB-2640, a p
Autor:
George Kemble, Natalie Cook, Kathleen N. Moore, Andrew Brenner, Jeffrey R. Infante, Shubham Pant, Emma Dean, Hendrik-Tobias Arkenau, Erkut Borazanci, Katharine Grimmer, Howard A. Burris, Manish R. Patel, Juanita Lopez, Gerald Steven Falchook, Peter Schmid, William McCulloch, Arthur E. Frankel, Marie O'Farrell
Publikováno v:
EClinicalMedicine
EClinicalMedicine, Vol 34, Iss, Pp 100797-(2021)
EClinicalMedicine, Vol 34, Iss, Pp 100797-(2021)
Background We conducted a first-in-human dose-escalation study with the oral FASN inhibitor TVB-2640 to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as monotherapy and with a taxane. Methods This completed open-labe
Autor:
Kevin M. Regan, Elisabet Cuyàs, George Kemble, Chandra Mohan Kurapaty Venkatapoorna, Ruth Lupu, Barbara Schroeder, Joan Montero, Zeng Hu, Sara Verdura, Karen S. Flatten, Ingrid Espinoza, Javier A. Menendez, Aina Arbusà, Fernando Martín Silva, X. Wei Meng, Paula A. Schneider, Scott H. Kaufmann, Travis Vander Steen
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Cell Death & Disease, 2021, vol. 12, art.núm.977
Articles publicats (IdIBGi)
Schroeder, Barbara Steen, Travis Vander Espinoza, Ingrid Venkatapoorna, Chandra M. Kurapaty Hu, Zeng Silva, Fernando Martín Regan, Kevin Cuyàs, Elisabet Meng, X. Wei Verdura, Sara Arbusà, Aina Schneider, Paula A. Flatten, Karen S. Kemble, George Montero, Joan Kaufmann, Scott H. Menéndez Menéndez, Javier Abel Lupu, Ruth 2021 Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells Cell Death & Disease 12 art.núm.977
DUGiDocs – Universitat de Girona
instname
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Cell Death & Disease, 2021, vol. 12, art.núm.977
Articles publicats (IdIBGi)
Schroeder, Barbara Steen, Travis Vander Espinoza, Ingrid Venkatapoorna, Chandra M. Kurapaty Hu, Zeng Silva, Fernando Martín Regan, Kevin Cuyàs, Elisabet Meng, X. Wei Verdura, Sara Arbusà, Aina Schneider, Paula A. Flatten, Karen S. Kemble, George Montero, Joan Kaufmann, Scott H. Menéndez Menéndez, Javier Abel Lupu, Ruth 2021 Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells Cell Death & Disease 12 art.núm.977
DUGiDocs – Universitat de Girona
instname
Inhibitors of the lipogenic enzyme fatty acid synthase (FASN) have attracted much attention in the last decade as potential targeted cancer therapies. However, little is known about the molecular determinants of cancer cell sensitivity to FASN inhibi
Autor:
Stephen A. Harrison, Jeffrey D. Wayne, Julio A. Gutierrez, George Kemble, Vlad Ratziu, Veeral Ajmera, Gregory J. Gores, James F. Trotter, Marie O'Farrell, Robert S. Rahimi, Vincent Wai-Sun Wong, Robert G. Perry, Rohit Loomba, William McCulloch, Katharine Grimmer, Mary E. Rinella, Brent A. Neuschwander-Tetri, Rizwana Mohseni, K. Jean Lucas
Publikováno v:
Gastroenterology
Gastroenterology, WB Saunders, 2021, pp.S0016-5085(21)03276-5. ⟨10.1053/j.gastro.2021.07.025⟩
Gastroenterology, 2021, pp.S0016-5085(21)03276-5. ⟨10.1053/j.gastro.2021.07.025⟩
Gastroenterology, vol 161, iss 5
Gastroenterology, WB Saunders, 2021, pp.S0016-5085(21)03276-5. ⟨10.1053/j.gastro.2021.07.025⟩
Gastroenterology, 2021, pp.S0016-5085(21)03276-5. ⟨10.1053/j.gastro.2021.07.025⟩
Gastroenterology, vol 161, iss 5
International audience; Background & Aims: Increased de novo lipogenesis creates excess intrahepatic fat and lipotoxins, propagating liver damage in nonalcoholic steatohepatitis. TVB-2640, a fatty acid synthase inhibitor, was designed to reduce exces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57482c0fcf4df6613f10c3d5d2fe74c
https://hal.sorbonne-universite.fr/hal-03335540
https://hal.sorbonne-universite.fr/hal-03335540
Autor:
Peter Schmid, Kathleen N. Moore, Andrew Brenner, Arthur E. Frankel, Gerald Steven Falchook, H. A. Burris, Katharine Grimmer, Juanita Lopez, George Kemble, EM Dean, J. R. Infante, William McCulloch, Erkut Borazanci, Steven J.M. Jones, Manish R. Patel, H.-T. Arkenau
Publikováno v:
Cancer Research. 77:P6-11
Introduction FASN inhibition is a novel approach to cancer treatment involving selective disruption of palmitate biosynthesis that, in tumor cells, leads to apoptosis. TVB-2640 is an oral, first-in-class, small molecule reversible inhibitor of FASN t
Autor:
Douglas Buckley, Timothy S. Heuer, Julie Lai, George Kemble, Kasia Mordec, Richard Benn Abegania Ventura, Marina Fridlib
Publikováno v:
EBioMedicine, Vol 16, Iss C, Pp 51-62 (2017)
EBioMedicine
EBioMedicine
Palmitate, the enzymatic product of FASN, and palmitate-derived lipids support cell metabolism, membrane architecture, protein localization, and intracellular signaling. Tubulins are among many proteins that are modified post-translationally by acyla
Autor:
Arthur E. Frankel, George Kemble, Peter Schmid, Howard A. Burris, Gerald Steven Falchook, Manish R. Patel, Hendrik-Tobias Arkenau, Kathleen N. Moore, Jeffrey R. Infante, Andrew Brenner, Suzanne F. Jones, William McCulloch, Juanita Lopez, Erkut Borazanci, Emma Dean
Publikováno v:
Cancer Research. 77:CT153-CT153
Introduction FASN inhibition causes selective disruption of palmitate biosynthesis that, in tumor cells, leads to apoptosis. TVB-2640 is an oral, first-in-class, small molecule reversible inhibitor of FASN that demonstrated in vivo antitumor effects.
Publikováno v:
Journal of Virology. 70:2044-2048
We have constructed defined human cytomegalovirus (CMV) mutants by cotransfecting overlapping cosmid clones spanning the 230-kbp genome. Using this strategy, we have introduced a 13-kbp region of DNA from a virulent strain of CMV into a defined posit
Autor:
Timothy S. Heuer, Richard Benn Abegania Ventura, Douglas Buckley, Julie Lai, George Kemble, Claudia Rubio, Joanna Waszczuk, Glenn Hammonds, Marie O' Farrell
Publikováno v:
Cancer Research. 76:4743-4743
Tumor cells have an increased dependence on FASN-synthesized palmitate compared to non-tumor cells, which obtain many of their required lipids from the extracellular milieu. Palmitate and palmitate-derived lipids comprise diverse cellular components
Autor:
Howard A. Burris, Hendrik-Tobias Arkenau, Peter Schmid, Erkut Borazanci, Arthur E. Frankel, Andrew Brenner, Emma Dean, Marie O'Farrell, Gerald Steven Falchook, George Kemble, Jeffrey R. Infante, Juanita Lopez, Shubham Pant, William McCulloch, Suzanne F. Jones, Manish R. Patel
Publikováno v:
Journal of Clinical Oncology. 34:2512-2512
2512Background: FASN inhibition is a novel approach to cancer treatment involving selective disruption of palmitate biosynthesis that, in tumor cells, leads to apoptosis. TVB-2640 is an oral, first...